phosphorus-radioisotopes and Neutropenia

Topics: Animals; Bone Marrow; Bone Marrow Cells; Cell Survival; Dogs; Granulocytes; Half-Life; Hematopoiesis; Humans; In Vitro Techniques; Injections, Intramuscular; Injections, Intravenous; Isoflurophate; Kinetics; Leukemia, Lymphoid; Leukemia, Myeloid; Leukemia, Myeloid, Acute; Leukocytes; Methods; Neutropenia; Neutrophils; Phosphorus Radioisotopes; Remission, Spontaneous; Time Factors

Topics: Bacterial Infections; Cell Survival; Chromium Radioisotopes; Hematopoiesis; Hematopoietic Stem Cells; Humans; Isoflurophate; Kinetics; Leukocytosis; Neutropenia; Neutrophils; Phosphorus Radioisotopes; Thymidine; Time Factors; Tritium

Topics: Adolescent; Adult; Aged; Agranulocytosis; Anemia, Aplastic; Blood Transfusion; Bone Marrow Cells; Bone Marrow Examination; Cell Movement; Female; Granulocytes; Humans; Isoflurophate; Leukocyte Count; Leukocytes; Male; Middle Aged; Neutropenia; Phosphorus Radioisotopes

Topics: Adult; Aged; Agranulocytosis; Arthritis, Rheumatoid; Blood Volume; Cell Survival; Felty Syndrome; Female; Half-Life; Humans; Isoflurophate; Leukocyte Count; Male; Middle Aged; Muramidase; Neutropenia; Phosphorus Radioisotopes; Splenectomy

Leukocyte kinetic studies were performed by labelling neutrophilic leukocytes in vivo with radioactive diisopropylfluorophosphate and measuring the time taken for the label to traverse the myelocyte compartment, marrow granulocyte reservoir and blood (myelocyte-to-tissue transit time). Leukocyte specific activity (LSA) reached background levels within 17 to 22 days in normal subjects and more rapidly than normal in patients with neutropenia due to hypersplenism or marrow aplasia. When neutropenia was partially or completely corrected by splenectomy the label disappeared more slowly. In patients with stable neutrophilia the label disappeared slowly and a terminal plateau in the LSA curve was encountered. Analysis of LSA curves suggests that disappearance of labelled neutrophil cohorts is influenced by circulating neutrophil levels, not only by an effect on release of cells from the marrow granulocyte reservoir but also, directly or indirectly, by an effect on myelocyte proliferation.

Topics: Adolescent; Adult; Aged; Agranulocytosis; Biological Transport; Child; Female; Humans; Hypersplenism; Isoflurophate; Leukocyte Count; Leukocytes; Male; Middle Aged; Myeloproliferative Disorders; Neutropenia; Neutrophils; Phosphorus Radioisotopes; Splenectomy; Time Factors

Topics: Agranulocytosis; Blood Flow Velocity; Bronchopulmonary Sequestration; Cell Survival; Humans; Isoflurophate; Kinetics; Leukocyte Count; Neutropenia; Phosphorus Radioisotopes; Renal Dialysis; Time Factors