phosphorus-radioisotopes and Myositis--Inclusion-Body

Muscle phosphorus magnetic resonance spectroscopy was used to study oxidative metabolism at rest and during recovery from exercise in 7 patients with sporadic inclusion body myositis (s-IBM), compared with normal controls (n=8) and mitochondrial myopathies (n=20). At rest, 6/7 patients had elevated inorganic phosphates. Recovery parameters were not different from controls, in contrast with mitochondrial myopathies, who showed abnormal rest and recovery. The normal recovery suggests that mitochondrial oxidative capacity is not impaired in s-IBM.

Topics: Aged; Aged, 80 and over; Humans; Inclusion Bodies; Magnetic Resonance Spectroscopy; Middle Aged; Mitochondria; Muscle Fatigue; Muscle, Skeletal; Myositis, Inclusion Body; Oxidative Phosphorylation; Phosphates; Phosphorus Radioisotopes; Physical Exertion; Radionuclide Imaging