phosphorus-radioisotopes and Muscular-Diseases

phosphorus-radioisotopes has been researched along with Muscular-Diseases* in 3 studies

Trials

1 trial(s) available for phosphorus-radioisotopes and Muscular-Diseases

Article	Year
Caffeine impairs intramuscular energy balance in patients susceptible to malignant hyperthermia. Muscle & nerve, 2003, Volume: 28, Issue:3 Malignant hyperthermia (MH) is a metabolic myopathy with an abnormal release of calcium by the sarcoplasmic reticulum (SR), triggered by volatile anesthetics and succinylcholine. Similarly, caffeine enhances Ca(2+)release by the SR in vitro. In a prospective, randomized study, high-energy phosphates were studied by intramuscular 31-phosphorus magnetic resonance spectroscopy ((31)P-MRS) in 10 MH-susceptible (MHS) and 7 MH-nonsusceptible (MHN) subjects before and after injection of 0.5 ml caffeine (20 mM). Intramuscular energy balance, measured by the ratios of P(i)/PCr and P(i)/gamma-ATP, did not differ between MHS and MHN patients before and after intramuscular caffeine injection. However, within each group, P(i)/PCr and P(i)/gamma-ATP increased significantly only in the MHS group. Intramuscular caffeine injection seemed to impair the metabolic balance in MHS individuals. This may reflect a local calcium overload leading to consumption of high-energy phosphates and increase of inorganic phosphate. Intramuscular stimulation by caffeine and (31)P-MRS may provide a valuable tool to investigate MH-related metabolic disturbances. Topics: Adult; Age Factors; Caffeine; Calcium; Calcium Signaling; Disease Susceptibility; Female; Humans; Injections, Intramuscular; Magnetic Resonance Spectroscopy; Male; Malignant Hyperthermia; Metabolic Diseases; Middle Aged; Muscle, Skeletal; Muscular Diseases; Oxidative Phosphorylation; Phosphocreatine; Phosphorus; Phosphorus Radioisotopes; Prospective Studies; Radionuclide Imaging; Sex Factors	2003

Article

Year

Caffeine impairs intramuscular energy balance in patients susceptible to malignant hyperthermia.

Muscle & nerve, 2003, Volume: 28, Issue:3

Malignant hyperthermia (MH) is a metabolic myopathy with an abnormal release of calcium by the sarcoplasmic reticulum (SR), triggered by volatile anesthetics and succinylcholine. Similarly, caffeine enhances Ca(2+)release by the SR in vitro. In a prospective, randomized study, high-energy phosphates were studied by intramuscular 31-phosphorus magnetic resonance spectroscopy ((31)P-MRS) in 10 MH-susceptible (MHS) and 7 MH-nonsusceptible (MHN) subjects before and after injection of 0.5 ml caffeine (20 mM). Intramuscular energy balance, measured by the ratios of P(i)/PCr and P(i)/gamma-ATP, did not differ between MHS and MHN patients before and after intramuscular caffeine injection. However, within each group, P(i)/PCr and P(i)/gamma-ATP increased significantly only in the MHS group. Intramuscular caffeine injection seemed to impair the metabolic balance in MHS individuals. This may reflect a local calcium overload leading to consumption of high-energy phosphates and increase of inorganic phosphate. Intramuscular stimulation by caffeine and (31)P-MRS may provide a valuable tool to investigate MH-related metabolic disturbances.

Topics: Adult; Age Factors; Caffeine; Calcium; Calcium Signaling; Disease Susceptibility; Female; Humans; Injections, Intramuscular; Magnetic Resonance Spectroscopy; Male; Malignant Hyperthermia; Metabolic Diseases; Middle Aged; Muscle, Skeletal; Muscular Diseases; Oxidative Phosphorylation; Phosphocreatine; Phosphorus; Phosphorus Radioisotopes; Prospective Studies; Radionuclide Imaging; Sex Factors

2003

Other Studies

2 other study(ies) available for phosphorus-radioisotopes and Muscular-Diseases

Article	Year
[In vivo P-31 NMR spectroscopy study of muscle metabolism in disease and under the influence of drugs]. Therapie, 1987, Volume: 42, Issue:5 Topics: Adrenergic beta-Antagonists; Humans; Magnetic Resonance Spectroscopy; Muscles; Muscular Diseases; Phosphorus Radioisotopes; Physical Exertion	1987
Examination of a myopathy by phosphorus nuclear magnetic resonance. Lancet (London, England), 1981, Oct-10, Volume: 2, Issue:8250 A 16-year-old boy with myopathy, ophthalmoplegia, and raised basal metabolic rate was examined by the non-invasive technique of phosphorus-31 nuclear magnetic resonance (31 P NMR). The muscles of the forearm showed an abnormal 31P NMR spectrum with a high inorganic phosphate (Pi) content in relation to phosphocreatine (PCr) (PCr/Pi = 4; control = 10). This finding was compatible with the abnormality of mitochondrial function already established by biopsy and offers in addition an explanation for the raised oxygen consumption in this patient. The method of 31P NMR is suited to rapid non-invasive diagnosis in various muscle disorders. Topics: Acidosis; Adolescent; Humans; Hydrogen-Ion Concentration; Lactates; Magnetic Resonance Spectroscopy; Male; Mitochondria, Muscle; Muscular Diseases; Oxygen Consumption; Phosphates; Phosphocreatine; Phosphorus Radioisotopes	1981

Article

Year

[In vivo P-31 NMR spectroscopy study of muscle metabolism in disease and under the influence of drugs].

Therapie, 1987, Volume: 42, Issue:5

Topics: Adrenergic beta-Antagonists; Humans; Magnetic Resonance Spectroscopy; Muscles; Muscular Diseases; Phosphorus Radioisotopes; Physical Exertion

1987

Examination of a myopathy by phosphorus nuclear magnetic resonance.

Lancet (London, England), 1981, Oct-10, Volume: 2, Issue:8250

A 16-year-old boy with myopathy, ophthalmoplegia, and raised basal metabolic rate was examined by the non-invasive technique of phosphorus-31 nuclear magnetic resonance (31 P NMR). The muscles of the forearm showed an abnormal 31P NMR spectrum with a high inorganic phosphate (Pi) content in relation to phosphocreatine (PCr) (PCr/Pi = 4; control = 10). This finding was compatible with the abnormality of mitochondrial function already established by biopsy and offers in addition an explanation for the raised oxygen consumption in this patient. The method of 31P NMR is suited to rapid non-invasive diagnosis in various muscle disorders.

Topics: Acidosis; Adolescent; Humans; Hydrogen-Ion Concentration; Lactates; Magnetic Resonance Spectroscopy; Male; Mitochondria, Muscle; Muscular Diseases; Oxygen Consumption; Phosphates; Phosphocreatine; Phosphorus Radioisotopes

1981