phosphorus-radioisotopes and Mitochondrial-Myopathies

phosphorus-radioisotopes has been researched along with Mitochondrial-Myopathies* in 2 studies

Other Studies

2 other study(ies) available for phosphorus-radioisotopes and Mitochondrial-Myopathies

Article	Year
No correlation between muscle A3243G mutation load and mitochondrial function in vivo. Neurology, 2001, Apr-24, Volume: 56, Issue:8 The authors studied the relationship between the percentage level of A3243G mitochondrial DNA mutation and the degree of mitochondrial dysfunction in vivo in nine individuals from four pedigrees using phosphorus MRS in muscle. There was no significant correlation between mutation load and maximum rate of adenosine triphosphate production (V(max)). V(max) was normal in a subject with 32% A3243G in muscle, which is in contrast with a previous observation of markedly reduced V(max) in a patient with only 6% A3243G in muscle. Factors besides mutation load, such as nuclear genes, influence expression of the A3243G mutation in vivo. Topics: Adenosine Triphosphate; Adult; DNA, Mitochondrial; Female; Humans; Magnetic Resonance Spectroscopy; Male; Middle Aged; Mitochondrial Myopathies; Muscle, Skeletal; Pedigree; Phosphorus Radioisotopes; Point Mutation; Statistics, Nonparametric	2001
In vivo assessment of human skeletal muscle mitochondria respiration in health and disease. Molecular and cellular biochemistry, 1997, Volume: 174, Issue:1-2 One of many problems to be faced when assessing in vivo human muscle mitochondria respiration by phosphorus magnetic resonance spectroscopy (31P-MRS) is the definition of the correct reference population and the values of reference range. To take into account most factors that influence muscle activity as age, sex, physical activity; nutritional state etc., an exceedingly high number of different reference groups are needed. To overcome this problem we developed specific tests to assess separately in vivo the activity and the functionality of muscle mitochondria by 31P-MRS in clinical settings. By activity we refer to muscle whole metabolic activity, i.e. the total oxidative capacity of muscle mitochondria which is influenced by many factors (age, sex, physical activity, nutritional state etc.). By functionality we refer to the qualitative aspects of mitochondrial respiration which depends on the integrity of mitochondrial multienzyme systems and on substrate availability. Our tests have been experienced on some 1200 patients and are currently used to detect deficits of mitochondrial respiration and ion transport in patients with suspected primary or secondary muscle mitochondrial malfunctioning. Topics: Electron Transport; Humans; Magnetic Resonance Spectroscopy; Mitochondria, Muscle; Mitochondrial Myopathies; Muscle, Skeletal; Phosphorus Radioisotopes	1997

Article

Year

No correlation between muscle A3243G mutation load and mitochondrial function in vivo.

Neurology, 2001, Apr-24, Volume: 56, Issue:8

The authors studied the relationship between the percentage level of A3243G mitochondrial DNA mutation and the degree of mitochondrial dysfunction in vivo in nine individuals from four pedigrees using phosphorus MRS in muscle. There was no significant correlation between mutation load and maximum rate of adenosine triphosphate production (V(max)). V(max) was normal in a subject with 32% A3243G in muscle, which is in contrast with a previous observation of markedly reduced V(max) in a patient with only 6% A3243G in muscle. Factors besides mutation load, such as nuclear genes, influence expression of the A3243G mutation in vivo.

Topics: Adenosine Triphosphate; Adult; DNA, Mitochondrial; Female; Humans; Magnetic Resonance Spectroscopy; Male; Middle Aged; Mitochondrial Myopathies; Muscle, Skeletal; Pedigree; Phosphorus Radioisotopes; Point Mutation; Statistics, Nonparametric

2001

In vivo assessment of human skeletal muscle mitochondria respiration in health and disease.

Molecular and cellular biochemistry, 1997, Volume: 174, Issue:1-2

One of many problems to be faced when assessing in vivo human muscle mitochondria respiration by phosphorus magnetic resonance spectroscopy (31P-MRS) is the definition of the correct reference population and the values of reference range. To take into account most factors that influence muscle activity as age, sex, physical activity; nutritional state etc., an exceedingly high number of different reference groups are needed. To overcome this problem we developed specific tests to assess separately in vivo the activity and the functionality of muscle mitochondria by 31P-MRS in clinical settings. By activity we refer to muscle whole metabolic activity, i.e. the total oxidative capacity of muscle mitochondria which is influenced by many factors (age, sex, physical activity, nutritional state etc.). By functionality we refer to the qualitative aspects of mitochondrial respiration which depends on the integrity of mitochondrial multienzyme systems and on substrate availability. Our tests have been experienced on some 1200 patients and are currently used to detect deficits of mitochondrial respiration and ion transport in patients with suspected primary or secondary muscle mitochondrial malfunctioning.

Topics: Electron Transport; Humans; Magnetic Resonance Spectroscopy; Mitochondria, Muscle; Mitochondrial Myopathies; Muscle, Skeletal; Phosphorus Radioisotopes

1997