phosphorus-radioisotopes and Meningioma

phosphorus-radioisotopes has been researched along with Meningioma* in 8 studies

Other Studies

8 other study(ies) available for phosphorus-radioisotopes and Meningioma

ArticleYear
Primum non nocere: Multimodality management strategies when multiple mass lesions strike a single patient.
    Surgical neurology, 2001, Volume: 55, Issue:6

    The management of multiple symptomatic intracranial pathological processes in a single patient presents a rare and challenging problem for the neurosurgeon and the patient. Neurosurgeons must utilize a full spectrum of neurosurgical options to achieve the best patient outcome.. We present a unique case of a 63-year-old woman who presented with a large convexity meningioma causing headaches, an acoustic neuroma causing deafness and imbalance and a suprasellar arachnoid cyst compromising the visual fields. Therapeutic intervention was staged based on the primum non nocere concept. First, the patient underwent stereotactic intracavitary cyst irradiation using colloidal 32P. Secondly, microsurgical resection of the convexity meningioma was performed. Finally, Gamma Knife radiosurgery of the acoustic neuroma was performed. One year after multimodality management, the patient was neurologically improved. There was no evidence of meningioma or cyst recurrence and the growth of the acoustic neuroma was arrested.. This case demonstrates the value of multi-modality treatment of neurosurgical pathology, utilizing minimally invasive techniques when possible.

    Topics: Arachnoid Cysts; Female; Humans; Magnetic Resonance Imaging; Meningeal Neoplasms; Meningioma; Middle Aged; Minimally Invasive Surgical Procedures; Neuroma, Acoustic; Phosphorus Radioisotopes; Radiosurgery; Radiotherapy, Adjuvant; Sella Turcica; Stereotaxic Techniques; Tomography, X-Ray Computed; Treatment Outcome

2001
Aromatic DNA adducts in brain tumors by 32P-postlabeling analysis.
    Cancer letters, 1993, Oct-15, Volume: 74, Issue:1-2

    DNA from human brain tumor samples was analysed by the 32P-postlabeling technique for the presence of aromatic DNA adducts. Thirteen out of 16 samples showed low levels of adducts at 0.14-3.53 adducts per 10(9) nucleotides. Inter-individual variations in the patterns of these aromatic adducts were observed. On the other hand, none of 5 brain samples from epilepsy patients revealed any evidence of such adducts. The data demonstrated the presence of low level, large molecule aromatic DNA adducts in malignant brain tissues and these adducts may either result from environmental exposure to an undetermined genotoxic agent or from the aging process.

    Topics: Adenoma; Adult; Aged; Brain Chemistry; Brain Neoplasms; Carcinogens; Carcinoma, Squamous Cell; Chromatography, Thin Layer; Cytochrome P-450 Enzyme System; DNA Damage; DNA, Neoplasm; Epilepsy; Female; Glioma; Humans; Male; Meningioma; Middle Aged; Neurilemmoma; Phosphorus Radioisotopes; Pituitary Neoplasms; Polycyclic Compounds

1993
CT-guided stereotactic injection of radionuclide for treatment of brain tumors.
    Stereotactic and functional neurosurgery, 1992, Volume: 59, Issue:1-4

    The authors report on 40 brain tumor patients treated with CT-guided stereotactic injection of 198Au and 32P. Among the 40 cases were astrocytoma in 23 cases, craniopharyngioma in 9, meningioma in 4, pituitary adenoma in 2, and pinealoma and metastatic carcinoma each in 1 case. The tumors were all located in deep or important areas of the brain which were difficult to deal with by conventional operation. 62 injections of colloidal isotopes were performed, and all were successful. No major adverse effects or complications occurred on follow-up of 6-12 months, 28 patients were improved in their clinical symptoms, and CT scanning showed that the tumor sizes were diminished. The effective rate is 70%.

    Topics: Adenoma; Adult; Astrocytoma; Brain Neoplasms; Craniopharyngioma; Female; Gold Radioisotopes; Humans; Male; Meningeal Neoplasms; Meningioma; Phosphorus Radioisotopes; Pinealoma; Pituitary Neoplasms; Radiosurgery; Stereotaxic Techniques; Tomography, X-Ray Computed

1992
Surgery of brain neoplasms using 32-P tumour marker.
    Acta neurochirurgica, 1989, Volume: 97, Issue:3-4

    In a series of 60 patients 62 intraoperative measurements with the 32-P (radiophosphorus) tumour marker were performed. Using miniature semiconductor probes a reliable discrimination between normal brain and neoplastic tissue was possible in nearly all brain tumours. The best results were found in meningiomas, where even small, visually hardly discernible tumour resides within the matrix zone could be reliably detected. Only in low-grade gliomas the application of the 32-P marker was impossible due to count rates similar to or below the basic rates of normal brain. This simple to use, non-invasive method proved its usefulness in all situations where a local radical tumour removal was important.

    Topics: Adult; Aged; Biomarkers, Tumor; Brain Neoplasms; Female; Humans; Male; Meningeal Neoplasms; Meningioma; Middle Aged; Neoplasms, Nerve Tissue; Phosphorus Radioisotopes

1989
Topographic studies with 32P tumor marker during operations of brain tumors.
    European surgical research. Europaische chirurgische Forschung. Recherches chirurgicales europeennes, 1985, Volume: 17, Issue:6

    A method for the intraoperative detection of brain tumor propagation is described. Based on the well-known radiophosphorus test, a very sensitive semiconductor probe was tested in 16 brain tumor operations. With this miniaturized sensor, the beta-emission of 32P could be measured with a high topographical resolution. Especially in high-grade gliomas, in meningiomas and in metastases a good discrimination of normal and tumor-infiltrated tissue was possible. The perspectives of a technical improvement of this method and the application of more specific tumor markers are discussed.

    Topics: Brain Neoplasms; Female; Glioma; Humans; Male; Meningeal Neoplasms; Meningioma; Middle Aged; Phosphorus Radioisotopes; Radionuclide Imaging; Tomography, X-Ray Computed

1985
Influence of hyperthermia on the phosphorylation of ribosomal protein S6 from human skin fibroblasts and meningioma cells.
    FEBS letters, 1983, Mar-21, Volume: 153, Issue:2

    Skin fibroblasts and meningioma cells, derived from primary cultures of the same patients have been used to study the influence of hyperthermia on (i) cell morphology and (ii) phosphorylation pattern of ribosomal and ribosome-associated proteins. Incubation of tumour cells and fibroblasts up to 7 h at 42 degrees C did not significantly change the cell morphology as compared to control cells kept at 37 degrees C. At 42 degrees C ribosomal protein S6 is shifted cathodically indicating a loss of negative charge, however no quantitative dephosphorylation of S6 was observed. Meningioma cells and fibroblasts did not differ significantly with respect to S6 phosphorylation.

    Topics: Cells, Cultured; Fibroblasts; Hot Temperature; Humans; Kinetics; Meningioma; Phosphates; Phosphorus Radioisotopes; Phosphorylation; Ribosomal Protein S6; Ribosomal Proteins; Skin

1983
The detection of tumour remnants in the parasellar region during operation with new semiconductor probes.
    Acta neurochirurgica. Supplementum, 1979, Volume: 28, Issue:2

    Topics: Brain Neoplasms; Craniopharyngioma; Glioma; Humans; Meningioma; Phosphorus Radioisotopes; Radionuclide Imaging; Sella Turcica; Semiconductors

1979
Proteins from human cerebrospinal fluid: binding with nucleic acids.
    Science (New York, N.Y.), 1973, Oct-19, Volume: 182, Issue:4109

    Cerebrospinal fluid (CSF) contains two groups of proteins that bind tightly to DNA and to polyriboguanylic acid, respectively. In certain diseases the amounts of a given nucleic acid bound by a constant volume of CSF may increase, while in others the amount of such proteins may be reduced. Binding of polyriboguanylic acid increased in CSF samples from patients with brain tumors, stroke, multiple sclerosis, and communicating hydrocephalus, but it significantly decreased in CSF samples from patients with obstructive hydrocephalus. These increases may or may not be proportional to the rise in total CSF proteins characteristic for these diseases. Elevated binding of DNA was observed in samples from patients with hydrocephalus, epilepsy, and cortical atrophy. The technique described may be applicable to the diagnosis of a variety of diseases of the central nervous system.

    Topics: Alcoholism; Astrocytoma; Brain Diseases; Brain Injuries; Brain Neoplasms; Carcinoma; Cerebrospinal Fluid Proteins; Cerebrovascular Disorders; Child, Preschool; DNA; Epilepsy; Female; Guanine Nucleotides; Headache; Humans; Hydrocephalus; Meningioma; Middle Aged; Multiple Sclerosis; Neurilemmoma; Phosphorus Radioisotopes; Polynucleotides; Protein Binding; Schizophrenia; Tritium

1973
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