phosphorus-radioisotopes and Macular-Degeneration

An infrared sensor was inserted at the film plane of a fundus camera. The signal was visualized on an oscilloscope. In this manner we measured infrared reflectance from the surface of the fundus. The purpose was to characterize choroidal malignant melanomas more reliably than is done with infrared color translation photography. Control lesions were choroidal nevi, metastatic tumors, and disciform macular degenerations. Correlations were made with radioactive phosphorus (32P) uptake, fluorescein angiography, and histopathologic findings. Several cases are presented, one in which this new method of infrared detection was the first diagnostic test to detect the spread of a choroidal melanoma. The simplicity of this technique and its increased accuracy justify the needed further refinements.

Topics: Adult; Aged; Choroid Neoplasms; Female; Fluorescein Angiography; Fundus Oculi; Humans; Infrared Rays; Macular Degeneration; Melanoma; Middle Aged; Neoplasm Metastasis; Nevus; Phosphorus Radioisotopes; Photography; Ultrasonography