phosphorus-radioisotopes and Liver-Cirrhosis--Biliary

phosphorus-radioisotopes has been researched along with Liver-Cirrhosis--Biliary* in 2 studies

Other Studies

2 other study(ies) available for phosphorus-radioisotopes and Liver-Cirrhosis--Biliary

Article	Year
Hepatic phosphorus-31 magnetic resonance spectroscopy in primary biliary cirrhosis and its relation to prognostic models. Gut, 1996, Volume: 39, Issue:1 In vivo hepatic phosphorus-31 magnetic resonance spectroscopy (31P MRS) provides biochemical information about phosphorus metabolism.. To assess 31P MRS as a prognostic marker in patients with primary biliary cirrhosis (PBC) in relation to the current clinical prognostic models.. Twenty three patients with PBC of varying functional severity and 16 matched healthy volunteers were studied using in vivo 31P MRS. Spectra were acquired using a 1.5 T spectroscopy system. Peak area ratios of phosphomonoesters (PME), inorganic phosphate (Pi), and phosphodiesters (PDE) and nucleotide triphosphate (NTP) were calculated. Pugh score, Christensen prognostic index, and R value according to the Mayo model were calculated from the clinical data.. The PME/NTP, Pi/NTP, PME/PDE, and PME/Pi ratios and the PME signal height ratio (SHR) were significantly higher, while the PDE/NTP and PDE/SHR were significantly lower in PBC patients compared with healthy volunteers (p < 0.01). Significant correlations were seen between PME/Pi ratio and the prognostic index according to Christensen (r = 0.63, p < 0.001), R value according to the Mayo model (r = 0.45, p < 0.03), and with the Pugh score (r = 0.55, p < 0.007).. This study shows that PME/Pi ratio obtained from 31P MRS correlates well with all three of the commonly used models of prognosis in patients with PBC. A longitudinal study with larger number of patients is required to confirm these findings and elucidate the biochemical changes underlying this phenomenon. Topics: Adult; Biomarkers; Female; Humans; Liver Cirrhosis, Biliary; Magnetic Resonance Spectroscopy; Male; Middle Aged; Phosphorus Radioisotopes; Pilot Projects; Prognosis	1996
[31P-NMR spectroscopy of the human liver and bile]. Biulleten' eksperimental'noi biologii i meditsiny, 1988, Volume: 106, Issue:12 High-resolution 31P-NMR is used for the estimation of phosphate-containing compounds levels in native bile of healthy subjects and patients with primary biliary liver cirrhosis and also in the liver biopsies of patients with chronic calculous cholecystitis. The results demonstrate the possibilities of rapid comparative estimation of the content of main phosphate-containing compounds in human bile and liver biopsies aimed at clinical diagnosis of liver and bile duct diseases. Topics: Bile; Biopsy; Cholecystitis; Cholelithiasis; Chronic Disease; Humans; Liver; Liver Cirrhosis, Biliary; Magnetic Resonance Spectroscopy; Phosphates; Phosphorus Radioisotopes	1988

Article

Year

Hepatic phosphorus-31 magnetic resonance spectroscopy in primary biliary cirrhosis and its relation to prognostic models.

Gut, 1996, Volume: 39, Issue:1

In vivo hepatic phosphorus-31 magnetic resonance spectroscopy (31P MRS) provides biochemical information about phosphorus metabolism.. To assess 31P MRS as a prognostic marker in patients with primary biliary cirrhosis (PBC) in relation to the current clinical prognostic models.. Twenty three patients with PBC of varying functional severity and 16 matched healthy volunteers were studied using in vivo 31P MRS. Spectra were acquired using a 1.5 T spectroscopy system. Peak area ratios of phosphomonoesters (PME), inorganic phosphate (Pi), and phosphodiesters (PDE) and nucleotide triphosphate (NTP) were calculated. Pugh score, Christensen prognostic index, and R value according to the Mayo model were calculated from the clinical data.. The PME/NTP, Pi/NTP, PME/PDE, and PME/Pi ratios and the PME signal height ratio (SHR) were significantly higher, while the PDE/NTP and PDE/SHR were significantly lower in PBC patients compared with healthy volunteers (p < 0.01). Significant correlations were seen between PME/Pi ratio and the prognostic index according to Christensen (r = 0.63, p < 0.001), R value according to the Mayo model (r = 0.45, p < 0.03), and with the Pugh score (r = 0.55, p < 0.007).. This study shows that PME/Pi ratio obtained from 31P MRS correlates well with all three of the commonly used models of prognosis in patients with PBC. A longitudinal study with larger number of patients is required to confirm these findings and elucidate the biochemical changes underlying this phenomenon.

Topics: Adult; Biomarkers; Female; Humans; Liver Cirrhosis, Biliary; Magnetic Resonance Spectroscopy; Male; Middle Aged; Phosphorus Radioisotopes; Pilot Projects; Prognosis

1996

[31P-NMR spectroscopy of the human liver and bile].

Biulleten' eksperimental'noi biologii i meditsiny, 1988, Volume: 106, Issue:12

High-resolution 31P-NMR is used for the estimation of phosphate-containing compounds levels in native bile of healthy subjects and patients with primary biliary liver cirrhosis and also in the liver biopsies of patients with chronic calculous cholecystitis. The results demonstrate the possibilities of rapid comparative estimation of the content of main phosphate-containing compounds in human bile and liver biopsies aimed at clinical diagnosis of liver and bile duct diseases.

Topics: Bile; Biopsy; Cholecystitis; Cholelithiasis; Chronic Disease; Humans; Liver; Liver Cirrhosis, Biliary; Magnetic Resonance Spectroscopy; Phosphates; Phosphorus Radioisotopes

1988