phosphorus-radioisotopes and Leukocytosis

Fifty-one cases of pure, primary erythrocytosis were identified and followed at Hôpital Saint-Louis, Paris, and compared with 350 cases of polycythemia vera (PV) observed during the same period. At the initial evaluation, these cases did not differ from PV cases with respect to age, sex ratio, degree of red cell volume increase, and clinical symptoms. They did differ by the absence of splenomegaly, granulocytosis and thrombocytosis. At a late stage of evolution only a few cases developed classical criteria of PV. From this group of apparently homogeneous cases, two subgroups evolved. Sixty percent of the cases were highly responsive to myelosuppression with 32P. The median duration of the first remission was greater than five years, the mean yearly dose of 32P was very low, and there was a low incidence of complications. The other group (40% of cases) was relatively resistant to myelosuppressive agents. The development of better methods of investigate this disorder might help in discriminating these two groups from both an etiological and pathophysiological viewpoint. The thromboembolic risk of these diseases suggests that myelosuppressive therapy should be utilized in older patients with higher risk of vascular accidents, reserving phlebotomy for younger patients and those who are shown to be resistant to 32P therapy.

Topics: Adolescent; Adult; Aged; Female; Humans; Leukocytosis; Male; Middle Aged; Phosphorus Radioisotopes; Polycythemia; Polycythemia Vera; Splenomegaly; Thrombocytosis

Topics: Bacterial Infections; Cell Survival; Chromium Radioisotopes; Hematopoiesis; Hematopoietic Stem Cells; Humans; Isoflurophate; Kinetics; Leukocytosis; Neutropenia; Neutrophils; Phosphorus Radioisotopes; Thymidine; Time Factors; Tritium

Topics: Blood Cell Count; Blood Platelets; Erythrocytes; Humans; Leukocytes; Leukocytosis; Phosphorus Radioisotopes; Polycythemia Vera; Prognosis; Reticulocytes; Splenomegaly

Topics: Age Factors; Anaphylaxis; Animals; Burns; Coloring Agents; Electric Stimulation; Endothelium; Erythema; Guinea Pigs; Histamine; In Vitro Techniques; Inflammation; Leukocytosis; Phosphorus Radioisotopes; Rabbits; Rats; Serotonin; Time Factors; Ultraviolet Rays