phosphorus-radioisotopes and Inflammation

Topics: Adolescent; Autoimmune Diseases; Child; Hemarthrosis; Hemophilia A; Humans; Inflammation; Leukemia; Male; Osteoarthritis; Phosphorus Radioisotopes; Radiopharmaceuticals; Synovial Membrane

Fourty-three primary cerebral lymphomas (PCL) were histologically classified and examined for genome expression of Epstein Barr Virus (EBV) and human herpes virus 6 (HHV6) using dot blotting, polymerase chain reaction, and Southern blotting. Only 20 tumors (16 high grade and 4 low grade lymphomas) could be suitably placed into a category of the Updated Kiel Classification, whereas the non-classified 23 tumors were highly malignant B-lymphomas and referred to as small-cell (SC) or large-cell (LC) blastic PCL. Most of the LC PCL showed a tumor-like infiltration pattern with high cellular density and little remaining parenchyma, whereas the SC PCL more often showed an inflammation-like pattern characterized by loose arrangement of tumor cells and marked astrocytic, microglial and T-lymphocytic reaction. EBV genome was found in 3/3 AIDS cases, but in none of 40 immunocompetent cases, while HHV6 was detected in 2 tumors of immunocompetent patients. We conclude that (1) the Updated Kiel Classification is not applicable to a majority of PCL, and (2) EBV and HHV6 do not appear to play a major role in the pathogenesis of PCL in immunocompetent subjects.

Topics: Autopsy; Autoradiography; Biopsy; Blotting, Southern; Brain Neoplasms; Genome, Viral; Herpesvirus 4, Human; Herpesvirus 6, Human; Humans; Inflammation; Lymphoma; Lymphoma, AIDS-Related; Phosphorus Radioisotopes; Polymerase Chain Reaction

Five eyes containing choroidal melanomas were found, on histopathologic examination, to have traumatic episcleritis with foreign-body granulomas and scleral edema underlying the area of tumor. This reaction was clearly correlated with phosphorus 32 testing that had been performed one to four weeks earlier. In all cases, enucleation had been delayed for logistic reasons. Invasion of the sclera or intrascleral canals was found in each case, with extension to the episclera in two of three small melanomas. Although the cases are few, this degree of invasion was greater than that seen in our other small melanomas or in reported series. The possibility that manipulation and inflammation of this type might have an adverse stimulatory influence on some melanomas should be considered when planning delayed enucleation after 32P testing. The juxtaposition of cautery marks and intrascleral tumor in a further case of melanoma demonstrates another possible complication of 32P testing.

Topics: Aged; Choroid Neoplasms; Female; Foreign-Body Reaction; Humans; Inflammation; Male; Melanoma; Middle Aged; Neoplasm Invasiveness; Phosphorus Radioisotopes; Radionuclide Imaging; Sclera

We studied four patients with posterior brawny scleritis. Two underwent enucleation for suspected melanoma, and in the other two, the correct diagnosis was made and effective therapy begun. Of seven other eyes with brawny scleritis from other sources, five were enucleated after diagnosis of choroidal melanoma and one for suspected intraocular tumor. This experience and other previous reports indicate the high incidence of diagnostic confusion regarding brawny scleritis. We therefore emphasized clinical symptoms and signs of brawny scleritis: inflammation, tenderness or pain of the globe, history of collagen vascular disease, proptosis, bilaterality, and retinal and choroidal detachment. A preserved normal choroidal vascular pattern over an elevated subretinal mass may be indicative of posterior brawny scleritis. Scleral biopsy is useful for tissue diagnosis. Radioactive phosphorus uptake tests and ultrasonography may erroneously indicate choroidal melanoma and lead to enucleation of a potentially salvageable globe.

Topics: Adult; Aged; Choroid Neoplasms; Diagnosis, Differential; Diagnostic Errors; Exophthalmos; Female; Humans; Inflammation; Male; Melanoma; Middle Aged; Pain; Phosphorus Radioisotopes; Retinal Detachment; Sclera; Ultrasonography

Topics: Adolescent; Adult; Aged; Child; Female; Half-Life; Humans; Infections; Inflammation; Isoflurophate; Kinetics; Leukocyte Count; Leukocytes; Male; Middle Aged; Monocytes; Neutrophils; Phosphorus Radioisotopes; Prednisone; Skin Window Technique; Time Factors

Topics: Age Factors; Anaphylaxis; Animals; Burns; Coloring Agents; Electric Stimulation; Endothelium; Erythema; Guinea Pigs; Histamine; In Vitro Techniques; Inflammation; Leukocytosis; Phosphorus Radioisotopes; Rabbits; Rats; Serotonin; Time Factors; Ultraviolet Rays