phosphorus-radioisotopes and Hodgkin-Disease

In the past, we have clinically evaluated radiolabelled antibodies in Hodgkin's disease and hepatocellular cancer. Increased tumour pressure, reduced vascularity and poor diffusion has limited significant radiolabelled antibody tumour dose deposition. Using intratumoural infusion of macroaggregated albumin to blockade exiting vasculature followed by colloidal chromic 32Phosphorous, we have been able to achieve 75% to 100% tumour dose deposition by interstitial tumour infusion under computerised tomographic guidance. Phase I studies in a variety of solid tumours indicate extremely high doses may be achieved without toxicity (i.e. non-resectable pancreas 900,000 cGy to 1.7 million cGy) with tumour control and remission. This is a review of those studies and how the technique was applied.

Topics: Astrocytoma; Brachytherapy; Brain Neoplasms; Carcinoma, Hepatocellular; Carcinoma, Small Cell; Chemoembolization, Therapeutic; Chromium; Colloids; Dexamethasone; Head and Neck Neoplasms; Hodgkin Disease; Humans; Injections, Intralesional; Liver Neoplasms; Lung Neoplasms; Pancreatic Neoplasms; Phosphorus Radioisotopes; Radiography, Interventional; Radioimmunotherapy; Radiotherapy Dosage; Remission Induction; Serum Albumin; Tomography, X-Ray Computed

Topics: Adolescent; Adult; Aged; Female; Hodgkin Disease; Humans; Iodized Oil; Lymphography; Male; Phosphorus Radioisotopes; Pregnancy

Leucocytes from normal donors and leukemia patients were isolated and lebelled in vitro with 32P-orthophosphate in order to compare labelling characteristics of nuclear high-molecular weight RNA, labelling characteristics, nucleotide compositions and oligonucleotide frequencies of ribosomal 28 S RNA. These studies revealed 1. structural microheterogeneity of 28 S RNA between the various leukemia cells studies without presenting a leukemia-specific structural marker, 2. an impaired production of ribosomal 28 S RNA from its nuclear precursor 45 S RNA in acute myeloblastic leukemia compared to PHA-stimulated normal lymphocytes. In the second part of this work, the influence of RNA from immunocompetent lymphocytes on the PHA-stimulation of M. Hodgkin lymphocytes was analyzed; the third part deals with studies on macromolecular carriers forcytostatic anthracyclines in human leukemia cells.

Topics: Hodgkin Disease; Humans; In Vitro Techniques; Isotope Labeling; Leukemia; Leukocytes; Macromolecular Substances; Phosphorus Radioisotopes; RNA, Neoplasm; RNA, Ribosomal

The utilization of individualized irradiation methods in Hodgkin's disease is reported. The advantages are emphasized in comparison with a schematized mantile therapy.

Topics: Cobalt Radioisotopes; Hodgkin Disease; Mediastinal Neoplasms; Methods; Models, Anatomic; Phosphorus Radioisotopes; Radiation Protection; Radioisotope Teletherapy; Radiotherapy Dosage; Tomography; Ultrasonography

Topics: Aged; Cyclophosphamide; Hodgkin Disease; Humans; Intestinal Absorption; Leukemia, Lymphoid; Leukemia, Myeloid; Middle Aged; Multiple Myeloma; Phosphates; Phosphorus Radioisotopes

Topics: Adolescent; Adult; Aged; Antibodies, Viral; Antigens, Viral; Biopsy; Burkitt Lymphoma; Cell Survival; Child; Child, Preschool; Chromatography, Gel; DNA, Viral; Female; Herpesvirus 4, Human; Hodgkin Disease; Humans; Leukemia, Lymphoid; Lymphoma, Non-Hodgkin; Male; Middle Aged; Nucleic Acid Hybridization; Phosphorus Radioisotopes; Staining and Labeling

Topics: Adolescent; Age Factors; Child; Child, Preschool; Cobalt Radioisotopes; Female; Hodgkin Disease; Humans; Hungary; Infant; Lymphatic Metastasis; Lymphography; Male; Phosphorus Radioisotopes; Radiography, Thoracic; Radioisotope Teletherapy; Radionuclide Imaging; Radiotherapy Dosage; Sex Factors

Topics: Chromium Radioisotopes; Hodgkin Disease; Humans; Isotope Labeling; Leukemia, Lymphoid; Leukocyte Count; Leukocytes; Lung Neoplasms; Methods; Phosphorus Radioisotopes; Time Factors

Topics: Hodgkin Disease; Humans; Phosphorus; Phosphorus Radioisotopes; Phosphorus, Dietary; Polycythemia Vera; Radioactivity

Topics: Bone and Bones; Bone Neoplasms; Hodgkin Disease; Humans; Leukemia; Multiple Myeloma; Neoplasms; Phosphorus; Phosphorus Radioisotopes; Plasma Cells; Polycythemia Vera; Radioactivity

Topics: Hodgkin Disease; Humans; Leukemia; Lymphoma; Multiple Myeloma; Phosphorus; Phosphorus Radioisotopes; Plasma Cells; Polycythemia Vera

Topics: Hodgkin Disease; Humans; Phosphorus; Phosphorus Radioisotopes; Phosphorus, Dietary; Radioactivity

Topics: Arsenic; Fistula; Hodgkin Disease; Humans; Phosphorus; Phosphorus Radioisotopes; Phosphorus, Dietary; Radioactivity; Radioisotopes; Radiotherapy

Topics: Hodgkin Disease; Humans; Phosphorus; Phosphorus Radioisotopes; Phosphorus, Dietary; Radioactivity; Radioisotopes; Radiotherapy

Topics: Hodgkin Disease; Humans; Lymphoma; Phosphorus; Phosphorus Radioisotopes; Phosphorus, Dietary; Radioactivity