phosphorus-radioisotopes and Hemoglobinopathies

During the last 12 years, 86 apparently primary polycythemias have been observed in subjects less than 40 years old. In twelve of them a non-suspected cause has been found (seven abnormalities of the hemoglobin function). In 43 cases, all males, the erythrocytosis (red cell volume more than 36 ml/kg) was pure and stable, without any complication; this "benign erythrocytosis" probably depicts extreme values of the normal distribution of the red cell mass. In 31 cases, the disease had criteria similar to those of polycythemia vera observed in older patients; in 12 of these cases, severe thrombo-embolic complications have been observed at the very beginning of the disease; however no further complication has been seen, when the patients were actively treated (phlebotomies or 32P); at the present time, no one of these cases did show transformation into acute leukemia, but the long-term prognosis (beyond 15 years) cannot yet been precisely drawn.

Topics: Adolescent; Adult; Bloodletting; Erythrocyte Volume; Female; Follow-Up Studies; Hemoglobinometry; Hemoglobinopathies; Humans; Male; Myeloproliferative Disorders; Phosphorus Radioisotopes; Polycythemia; Polycythemia Vera; Thromboembolism

Topics: Adult; Anemia, Sickle Cell; Blood Protein Electrophoresis; Chromium Radioisotopes; Diagnosis, Differential; Erythrocyte Count; Erythrocytes; Female; Hematocrit; Hemoglobin, Sickle; Hemoglobinopathies; Hemoglobins, Abnormal; Humans; Male; Oxygen; Phosphorus Radioisotopes; Physical Exertion; Reticulocytes; Syndrome

Topics: Adenosine Triphosphate; Anemia, Hemolytic; Anemia, Sickle Cell; Autoradiography; Avian Myeloblastosis Virus; Cell-Free System; Centrifugation, Density Gradient; Chromatography, Affinity; Chromatography, DEAE-Cellulose; DNA; DNA Nucleotidyltransferases; Electrophoresis, Disc; Escherichia coli; Globins; Hemoglobin H; Hemoglobinopathies; Hemolysis; Humans; Nucleic Acid Hybridization; Oligonucleotides; Pancreas; Phosphorus Radioisotopes; Poly U; Reticulocytes; Ribonucleases; RNA, Messenger; Thalassemia; Ultracentrifugation

Topics: Adolescent; Black People; Blood Platelets; Bone Marrow Examination; Buffers; Cell Survival; Chromatography; Chromium Radioisotopes; Dextrans; Electrophoresis, Starch Gel; Erythrocytes; Glucosephosphate Dehydrogenase Deficiency; Heinz Bodies; Hemoglobinopathies; Hemoglobins, Abnormal; Hot Temperature; Humans; Iron; Male; Megakaryocytes; Phosphorus Radioisotopes; Splenectomy; Splenomegaly; Thrombocytopenia; Ultracentrifugation