phosphorus-radioisotopes and Carcinoma--Basal-Cell

This article describes a method for the preparation of (32)P patch for the treatment of skin cancer. It is based on the surface modification of a Nafion film by treatment with ZrOCl(2) solution, impregnation of a predicted quantity of (32)P into the film, and its subsequent immobilization into a nonleachable matrix by lamination. The effect of variations of critical parameters on the incorporation of (32)P into the membrane, such as solution pH, contact time, reaction volume, inactive carrier concentration of the feed, reaction temperature, and so on, was investigated to arrive at the conditions resulting in optimum retention of (32)P activity. The morphology of the membrane was evaluated by scanning electron microscope and energy dispersive spectral analyses. Quality control tests were carried out to ensure nonleachability, uniform distribution of activity, and stability of the patches.

Topics: Administration, Cutaneous; Brachytherapy; Carcinoma, Basal Cell; Fluorocarbon Polymers; Membranes, Artificial; Microscopy, Electron, Scanning; Phosphorus Radioisotopes; Radiopharmaceuticals; Skin Neoplasms; Zirconium

The authors have determined the distribution of 32P in normal skin and in the case of certain skin tumours (basalioma and spinalioma). In both groups a lognormal distribution was found. It may be assumed that the enrichment is governed by similar distribution in the case of melanoma malignum.

Topics: Carcinoma, Basal Cell; Carcinoma, Squamous Cell; Humans; Mathematics; Melanoma; Phosphorus Radioisotopes; Skin; Skin Neoplasms

In 21 patients with a variety of skin tumors (squamous cell carcinomas, malignant melanomas, basal cell epitheliomas and mycosis fungoides) or pre-cancerous lesions (Bowen's disease, actinic keratosis, junctional nevus cell nevus) the radioactive phosphorus uptake test demonstrates a significantly increased concentration of P32 in those tumors. There were no false negative tests. The possibility of differentiation of malignant melanoma from benign nevus cell nevus and the early recognition of cutaneous metastases is described. Furthermore recurrence of previously irradiated or excised basal cell epitheliomas can be detected without a biopsy. No hematological side-effects were observed.

Topics: Aged; Bowen's Disease; Carcinoma, Basal Cell; Carcinoma, Squamous Cell; Diagnosis, Differential; False Negative Reactions; Female; Humans; Keratosis; Male; Melanoma; Middle Aged; Mycosis Fungoides; Neoplasm Metastasis; Neoplasm Recurrence, Local; Nevus, Pigmented; Phosphorus; Phosphorus Radioisotopes; Precancerous Conditions; Radionuclide Imaging; Skin Neoplasms