phosphorus-radioisotopes and Arteriosclerosis-Obliterans

31P in-vivo spectroscopy was performed by a 1.5-tesla whole-body MR system. The 31P spectrum for the calf muscle in a patient with arteriosclerosis obliterans having intermittent claudication was obtained every two minutes. When the spectrum after the workload was compared with that at rest, an increase in inorganic phosphate (Pi) and a decrease in phosphocreatine (PCr) were observed, resulting in a strong decrease in the PCr/Pi ratio. This method can measure the ischemic and recovery stages of energy metabolism in skeletal muscle noninvasively and continuously in addition to magnetic resonance imaging.

Topics: Aged; Angiography; Arteriosclerosis Obliterans; Energy Metabolism; Humans; Intermittent Claudication; Leg; Magnetic Resonance Spectroscopy; Male; Muscles; Phosphates; Phosphocreatine; Phosphorus Radioisotopes; Radionuclide Imaging