phosphorus-radioisotopes and Acidosis--Lactic

phosphorus-radioisotopes has been researched along with Acidosis--Lactic* in 1 studies

Other Studies

1 other study(ies) available for phosphorus-radioisotopes and Acidosis--Lactic

Article	Year
Metabolic acidosis induced by N-methyl-D-aspartate in brain slices of the neonatal rat: 31P- and 1H-magnetic resonance spectroscopy. Neuroscience letters, 1988, Oct-17, Volume: 92, Issue:3 1H- and 31P-magnetic resonance spectroscopy was used to monitor intracellular lactate, phosphorus metabolites and pH in superfused brain slices from 2- to 9-day-old rats. N-Methyl-D-aspartate (NMDA) (100 microM, 0.5-3 min) was applied in the extracellular magnesium-free perfusion medium. NMDA induced intracellular metabolic acidosis, i.e., an increase of freely mobile lactate levels and an 0.3 pH unit acidification. This was abolished when the extracellular glucose supply was reduced. Experiments also indicate that acidosis is not responsible for the cell damage resulting from activation of NMDA receptors in hypoglycemic conditions. Topics: Acidosis, Lactic; Animals; Aspartic Acid; Frontal Lobe; Glucose; Hydrogen; Hydrogen-Ion Concentration; In Vitro Techniques; Magnetic Resonance Spectroscopy; N-Methylaspartate; Phosphorus Radioisotopes; Rats	1988

Article

Year

Metabolic acidosis induced by N-methyl-D-aspartate in brain slices of the neonatal rat: 31P- and 1H-magnetic resonance spectroscopy.

Neuroscience letters, 1988, Oct-17, Volume: 92, Issue:3

1H- and 31P-magnetic resonance spectroscopy was used to monitor intracellular lactate, phosphorus metabolites and pH in superfused brain slices from 2- to 9-day-old rats. N-Methyl-D-aspartate (NMDA) (100 microM, 0.5-3 min) was applied in the extracellular magnesium-free perfusion medium. NMDA induced intracellular metabolic acidosis, i.e., an increase of freely mobile lactate levels and an 0.3 pH unit acidification. This was abolished when the extracellular glucose supply was reduced. Experiments also indicate that acidosis is not responsible for the cell damage resulting from activation of NMDA receptors in hypoglycemic conditions.

Topics: Acidosis, Lactic; Animals; Aspartic Acid; Frontal Lobe; Glucose; Hydrogen; Hydrogen-Ion Concentration; In Vitro Techniques; Magnetic Resonance Spectroscopy; N-Methylaspartate; Phosphorus Radioisotopes; Rats

1988