phosphoramidon and Pre-Eclampsia

phosphoramidon has been researched along with Pre-Eclampsia* in 1 studies

Other Studies

1 other study(ies) available for phosphoramidon and Pre-Eclampsia

ArticleYear
Contribution of endogenous endothelin-1 to basal vascular tone during normal pregnancy and preeclampsia.
    American journal of obstetrics and gynecology, 2005, Volume: 193, Issue:1

    The aim of this study was to determine the physiologic role for endogenous endothelin in the regulation of vascular tone during normal pregnancy and preeclampsia. The vascular sensitivity to endothelin-1 during pregnancy was studied also.. Forearm blood flow was measured by venous occlusion plethysmography during intra-arterial infusion of phosphoramidon, an endothelin-converting enzyme inhibitor, for 60 minutes, which was followed by co-infusion with endothelin-1 for 30 minutes. Three groups were studied: healthy nonpregnant women, normal pregnant women, and women with preeclampsia.. There was a significant increase in forearm blood flow in the nonpregnant group after phosphoramidon infusion alone (73%+/-37%; P<.05). Phosphoramidon did not change forearm blood flow in pregnant subjects. Co-infusion with endothelin-1 significantly decreased forearm blood flow in both the nonpregnant and normal pregnant women (53%+/-7% and 40%+/-11%, respectively; P<.01). No response to endothelin-1 was found among women with preeclampsia.. The vascular sensitivity to endothelin-1 is not altered during normal pregnancy in contrast to preeclamptic pregnancy, where no effect of endothelin-1 was seen. Reduced endothelin dependence during pregnancy might be one mechanism behind the fall in peripheral vascular resistance.

    Topics: Adult; Aspartic Acid Endopeptidases; Case-Control Studies; Endothelin-1; Endothelin-Converting Enzymes; Female; Forearm; Glycopeptides; Humans; Metalloendopeptidases; Pre-Eclampsia; Pregnancy; Protease Inhibitors; Regional Blood Flow; Vasomotor System

2005