phosphoramidic acid has been researched along with Hepatitis C in 13 studies
*Hepatitis C: INFLAMMATION of the LIVER in humans caused by HEPATITIS C VIRUS, a single-stranded RNA virus. Its incubation period is 30-90 days. Hepatitis C is transmitted primarily by contaminated blood parenterally and is often associated with transfusion and intravenous drug abuse. However, in a significant number of cases, the source of hepatitis C infection is unknown. [MeSH]
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (15.38) | 29.6817 |
| 2010's | 9 (69.23) | 24.3611 |
| 2020's | 2 (15.38) | 2.80 |
| Authors | Studies |
|---|---|
| Amblard, F; Amiralaei, S; Coats, SJ; Ehteshami, M; Jiang, Y; Schinazi, RF; Shelton, J; Tao, S; Zhang, H; Zhou, L; Zhou, S | 1 |
| Dentmon, ZW; Kaiser, TM; Liotta, DC | 1 |
| Amblard, F; Amiralaei, S; Cho, JH; Coats, SJ; Ehteshami, M; Li, H; Lu, X; McBrayer, TR; Ozturk, T; Schinazi, RF; Shelton, JR; Stanton, R; Zhang, H; Zhou, L | 1 |
| Babusis, D; Cho, A; Fenaux, M; Feng, JY; Kim, CU; Kirschberg, TA; Mish, MR; Park, Y; Ray, AS; Squires, NH; Wang, KY; Zhang, L | 1 |
| Amblard, F; Amiralaei, S; Bassit, L; Bobeck, D; Cho, JH; Coats, SJ; Detorio, M; Ehteshami, M; McBrayer, TR; Pradere, U; Schinazi, RF; Tao, S; Whitaker, T; Zhang, HW; Zhou, L | 1 |
| De Jonghe, S; Gao, LJ; Herdewijn, P; Huang, C; Maiti, M; Murray, MG; Ptak, RG | 1 |
| Aktoudianakis, V; Appleby, TC; Babusis, D; Barauskas, O; Birkus, G; Butler, T; Byun, D; Chin, G; Cho, A; Clarke, MO; Doerffler, E; Edwards, TE; Fenaux, M; Feng, JY; Kim, CU; Kirschberg, TA; Lee, R; Lew, W; Metobo, S; Mish, MR; Murakami, E; Park, Y; Ray, AS; Squires, NH; Tirunagari, N; Wang, T; Whitcomb, M; Xu, J; Yang, H; Ye, H; Zhang, L | 1 |
| Madela, K; McGuigan, C; Neyts, J; Perrone, P | 1 |
| Attenni, B; Di Marco, A; Donghi, M; Fiore, F; Gardelli, C; Gennari, N; Giuliano, C; Harper, S; Laufer, R; Leone, JF; MacCoss, M; Marcucci, I; Meppen, M; Narjes, F; Olsen, DB; Pacini, B; Pucci, V; Rowley, M | 1 |
| Aljarah, M; Ames, B; Bryant, KD; Chamberlain, S; Ganguly, B; Gilles, A; Gorovits, E; Hall, A; Henson, G; Holl, S; Hunley, D; Hutchins, J; Jones, S; Kolykhalov, A; Liu, Y; Madela, K; McGuigan, C; Muhammad, J; Raja, N; Vernachio, J; Walters, R; Wang, J | 1 |
| Mehellou, Y | 1 |
| Aljarah, M; Battina, SK; Chamberlain, S; Gilles, A; Hall, A; Henson, G; Hutchins, J; Kolykhalov, A; Madela, K; McGuigan, C; Ramamurty, CV; Srinivas Rao, C; Vernachio, J | 1 |
| Rachakonda, S; Reddy, PG; Ross, BS; Sofia, MJ; Zhang, HR | 1 |
13 other study(ies) available for phosphoramidic acid and Hepatitis C
| Article | Year |
|---|---|
Intracellular metabolism and potential cardiotoxicity of a β-D-2'-
Topics: Amides; Animals; Antiviral Agents; Cardiotoxicity; Cell Line, Tumor; Energy Metabolism; Hepacivirus; Hepatitis C; Hepatocytes; Humans; Metabolic Networks and Pathways; Metabolome; Metabolomics; Myocytes, Cardiac; Phosphoric Acids; Prodrugs; Virus Replication | 2020 |
Synthesis and Antiviral Activity of a Series of 2'-
Topics: Amides; Antiviral Agents; Cell Line; Drug Evaluation, Preclinical; Hepacivirus; Hepatitis C; Humans; Nucleosides; Phosphates; Phosphoric Acids; Prodrugs; Thionucleosides; Viral Nonstructural Proteins | 2020 |
Nucleotide Substrate Specificity of Anti-Hepatitis C Virus Nucleoside Analogs for Human Mitochondrial RNA Polymerase.
Topics: Amides; Antiviral Agents; Catalytic Domain; DNA-Directed RNA Polymerases; Hepacivirus; Hepatitis C; Humans; Mitochondria; Nucleosides; Phosphoric Acids; Sofosbuvir; Structure-Activity Relationship; Substrate Specificity | 2017 |
Synthesis and characterization of 1'-C-cyano-2'-fluoro-2'-C-methyl pyrimidine nucleosides as HCV polymerase inhibitors.
Topics: Amides; Antiviral Agents; Cell Line; Halogenation; Hepacivirus; Hepatitis C; Humans; Methylation; Phosphoric Acids; Prodrugs; Pyrimidine Nucleosides; Replicon; RNA-Dependent RNA Polymerase | 2015 |
β-D-2'-C-Methyl-2,6-diaminopurine Ribonucleoside Phosphoramidates are Potent and Selective Inhibitors of Hepatitis C Virus (HCV) and Are Bioconverted Intracellularly to Bioactive 2,6-Diaminopurine and Guanosine 5'-Triphosphate Forms.
Topics: 2-Aminopurine; Amides; Antiviral Agents; Cell Line; Cells, Cultured; Guanosine Triphosphate; Hepacivirus; Hepatitis C; Humans; Methylation; Phosphoric Acids; Prodrugs; Ribonucleosides | 2015 |
Bifunctional aryloxyphosphoramidate prodrugs of 2'-C-Me-uridine: synthesis and anti-HCV activity.
Topics: Amides; Antiviral Agents; Chemistry Techniques, Synthetic; Hepacivirus; Hepatitis C; Humans; Microsomes, Liver; Phosphoric Acids; Prodrugs; Uridine; Virus Replication | 2016 |
Discovery of a 2'-fluoro-2'-C-methyl C-nucleotide HCV polymerase inhibitor and a phosphoramidate prodrug with favorable properties.
Topics: Amides; Animals; Antiviral Agents; Caco-2 Cells; Cell Line; Cricetinae; Drug Discovery; Drug Resistance, Viral; Halogenation; Hepacivirus; Hepatitis C; Humans; Methylation; Molecular Docking Simulation; Nucleosides; Phosphoric Acids; Point Mutation; Prodrugs; Viral Nonstructural Proteins; Virus Replication | 2017 |
The phosphoramidate ProTide approach greatly enhances the activity of beta-2'-C-methylguanosine against hepatitis C virus.
Topics: Amides; Amino Acids; Antiviral Agents; Chemistry, Pharmaceutical; Drug Design; Esters; Guanosine; Hepacivirus; Hepatitis C; Humans; Hydrolysis; Magnetic Resonance Spectroscopy; Models, Chemical; Phosphoric Acids; Prodrugs | 2009 |
Phosphoramidate prodrugs of 2'-C-methylcytidine for therapy of hepatitis C virus infection.
Topics: Amides; Animals; Antiviral Agents; Cell Line; Cytidine; Hepacivirus; Hepatitis C; Hepatocytes; Humans; Phosphoric Acids; Polyphosphates; Prodrugs; Structure-Activity Relationship; Virus Replication | 2009 |
Phosphoramidate ProTides of 2'-C-methylguanosine as highly potent inhibitors of hepatitis C virus. Study of their in vitro and in vivo properties.
Topics: Adenosine Triphosphate; Amides; Animals; Antiviral Agents; Cell Line; Female; Guanosine; Hepacivirus; Hepatitis C; Humans; Liver; Magnetic Resonance Spectroscopy; Mice; Mice, Inbred ICR; Phosphoric Acids; Virus Replication | 2010 |
Phosphoramidate prodrugs deliver with potency against hepatitis C virus.
Topics: Amides; Anti-HIV Agents; DNA-Directed RNA Polymerases; Guanosine; Hepacivirus; Hepatitis C; Humans; Phosphoric Acids; Prodrugs; Pyrimidine Nucleosides | 2010 |
Dual pro-drugs of 2'-C-methyl guanosine monophosphate as potent and selective inhibitors of hepatitis C virus.
Topics: Amides; AMP Deaminase; Antiviral Agents; Cell Line, Tumor; Drug Design; Drug Evaluation, Preclinical; Guanosine Monophosphate; Hepacivirus; Hepatitis C; Humans; Hydrolysis; Inhibitory Concentration 50; Microbial Sensitivity Tests; Molecular Structure; Nucleosides; Phosphoric Acids; Phosphorylation; Prodrugs; Stereoisomerism; Structure-Activity Relationship; Virus Replication | 2011 |
Synthesis of diastereomerically pure nucleotide phosphoramidates.
Topics: Amides; Amino Acids; Antiviral Agents; Chemistry, Pharmaceutical; Chromatography, High Pressure Liquid; DNA-Directed RNA Polymerases; Electrons; Esters; Hepacivirus; Hepatitis C; Humans; Magnetic Resonance Spectroscopy; Nucleosides; Nucleotides; Phenols; Phosphoric Acids; Prodrugs; Sofosbuvir; Stereoisomerism; Structure-Activity Relationship; Uridine Monophosphate; Viral Proteins | 2011 |