phosphonoacetic acid and Pancreatic Neoplasms
phosphonoacetic acid has been researched along with Pancreatic Neoplasms in 9 studies
Phosphonoacetic Acid: A simple organophosphorus compound that inhibits DNA polymerase, especially in viruses and is used as an antiviral agent.
phosphonoacetic acid : A member of the class of phosphonic acids that is phosphonic acid in which the hydrogen attached to the phosphorous is replaced by a carboxymethyl group.
Pancreatic Neoplasms: Tumors or cancer of the PANCREAS. Depending on the types of ISLET CELLS present in the tumors, various hormones can be secreted: GLUCAGON from PANCREATIC ALPHA CELLS; INSULIN from PANCREATIC BETA CELLS; and SOMATOSTATIN from the SOMATOSTATIN-SECRETING CELLS. Most are malignant except the insulin-producing tumors (INSULINOMA).
Research Excerpts
Excerpt | Relevance | Reference |
---|---|---|
"To evaluate the effect of biochemical modulation by PALA and methotrexate on the therapeutic activity of 5-fluorouracil (5-FU) in patients with advanced pancreatic adenocarcinoma." | 3.69 | Modulation of 5-fluorouracil with methotrexate and low-dose N-(phosphonacetyl)-L-aspartate (PALA) is inactive in advanced pancreatic carcinoma. ( Berns, T; Harstrick, A; Hiddemann, W; Köhne, CH; Preusser, P; Schmoll, HJ; Seeber, S; Strumberg, D; Wilke, H, 1997) |
"One of the responding patients with colon cancer and two with breast cancer had failed to respond to prior therapy with 5-FU; one of the responding patients with breast cancer had previously received an inadequate trial of a similar regimen." | 1.26 | Phase II trial of combination therapy with continuous-infusion PALA and bolus-injection 5-FU. ( Ervin, TJ; Kufe, DW; Meshad, MW; Weiss, GR, 1982) |
Research
Studies (9)
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 3 (33.33) | 18.7374 |
1990's | 5 (55.56) | 18.2507 |
2000's | 1 (11.11) | 29.6817 |
2010's | 0 (0.00) | 24.3611 |
2020's | 0 (0.00) | 2.80 |
Authors
Authors | Studies |
---|---|
Whitehead, RP | 1 |
Benedetti, JK | 1 |
Abbruzzese, JL | 1 |
Ardalan, B | 3 |
Goodwin, JW | 1 |
Balcerzak, SP | 1 |
Samlowski, WE | 1 |
Lenz, HJ | 1 |
Macdonald, JS | 2 |
Erlichman, C | 1 |
Donehower, RC | 1 |
Speyer, JL | 1 |
Klecker, R | 1 |
Chabner, BA | 1 |
Weiss, GR | 1 |
Ervin, TJ | 1 |
Meshad, MW | 1 |
Kufe, DW | 1 |
Redei, I | 1 |
Green, F | 1 |
Hoffman, JP | 1 |
Weiner, LM | 1 |
Scher, R | 1 |
O'Dwyer, PJ | 2 |
Ucar, A | 1 |
Reddy, R | 1 |
Livingstone, AS | 1 |
Markoe, A | 1 |
Schwade, J | 1 |
Richman, SP | 2 |
Donofrio, K | 1 |
Harstrick, A | 1 |
Köhne, CH | 1 |
Hiddemann, W | 1 |
Preusser, P | 1 |
Strumberg, D | 1 |
Berns, T | 1 |
Seeber, S | 1 |
Wilke, H | 1 |
Schmoll, HJ | 1 |
Rosvold, E | 1 |
Schilder, R | 1 |
Walczak, J | 1 |
DiFino, SM | 1 |
Flynn, PJ | 1 |
Banerjee, TK | 1 |
Heim, WJ | 1 |
Engstrom, PF | 1 |
Ozols, RF | 1 |
Morrell, LM | 1 |
Bach, A | 1 |
Goodman, P | 1 |
Fleming, TR | 1 |
Singh, G | 1 |
Silberman, H | 1 |
Trials
6 trials available for phosphonoacetic acid and Pancreatic Neoplasms
Article | Year |
---|---|
A phase II study of high-dose 24 hour continuous infusion 5-FU and leucovorin and low-dose PALA for patients with advanced pancreatic adenocarcinoma: a Southwest Oncology Group Study.
Topics: Adenocarcinoma; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Aspartic Acid; Dose-Res | 2004 |
Phase II trial of PALA and 6-methylmercaptopurine riboside (MMPR) in combination with 5-fluorouracil in advanced pancreatic cancer.
Topics: Adenocarcinoma; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Aspartate Carbamoyltran | 1994 |
Phase I trial of low dose N-phosphonacetyl-L-aspartic acid and high dose 5-fluorouracil administered concomitantly with radiation therapy for unresectable localized adenocarcinoma of the pancreas.
Topics: Adenocarcinoma; Aged; Antineoplastic Combined Chemotherapy Protocols; Aspartic Acid; Combined Modali | 1994 |
Phase II trial of PALA in combination with 5-fluorouracil in advanced pancreatic cancer.
Topics: Adenocarcinoma; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Asp | 1992 |
A phase II multi-institutional trial of low-dose N-(phosphonacetyl)-L-aspartate and high-dose 5-fluorouracil as a short-term infusion in the treatment of adenocarcinoma of the pancreas. A Southwest Oncology Group study.
Topics: Adenocarcinoma; Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Antineoplastic Combined Chemo | 1991 |
A randomized phase I and II study of short-term infusion of high-dose fluorouracil with or without N-(phosphonacetyl)-L-aspartic acid in patients with advanced pancreatic and colorectal cancers.
Topics: Adult; Aged; Antineoplastic Agents; Aspartic Acid; Colonic Neoplasms; Drug Administration Schedule; | 1988 |
Other Studies
3 other studies available for phosphonoacetic acid and Pancreatic Neoplasms
Article | Year |
---|---|
Phase I-phase II trial of N-phosphonacetyl-L-aspartic acid given by intravenous infusion and 5-fluorouracil given by bolus injection.
Topics: Adult; Aged; Antineoplastic Agents; Aspartic Acid; Colonic Neoplasms; Drug Administration Schedule; | 1982 |
Phase II trial of combination therapy with continuous-infusion PALA and bolus-injection 5-FU.
Topics: Adult; Aged; Aspartic Acid; Breast Neoplasms; Carcinoma; Colonic Neoplasms; Drug Evaluation; Drug Th | 1982 |
Modulation of 5-fluorouracil with methotrexate and low-dose N-(phosphonacetyl)-L-aspartate (PALA) is inactive in advanced pancreatic carcinoma.
Topics: Adenocarcinoma; Adolescent; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Aspartic Ac | 1997 |