phosphonoacetic acid has been researched along with Li-Fraumeni Syndrome in 3 studies
Phosphonoacetic Acid: A simple organophosphorus compound that inhibits DNA polymerase, especially in viruses and is used as an antiviral agent.
phosphonoacetic acid : A member of the class of phosphonic acids that is phosphonic acid in which the hydrogen attached to the phosphorous is replaced by a carboxymethyl group.
Li-Fraumeni Syndrome: Rare autosomal dominant syndrome characterized by mesenchymal and epithelial neoplasms at multiple sites. MUTATION of the p53 tumor suppressor gene, a component of the DNA DAMAGE response pathway, apparently predisposes family members who inherit it to develop certain cancers. The spectrum of cancers in the syndrome was shown to include, in addition to BREAST CANCER and soft tissue sarcomas (SARCOMA); BRAIN TUMORS; OSTEOSARCOMA; LEUKEMIA; and ADRENOCORTICAL CARCINOMA.
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (100.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Tlsty, TD | 2 |
| White, A | 2 |
| Livanos, E | 2 |
| Sage, M | 1 |
| Roelofs, H | 1 |
| Briot, A | 1 |
| Poulose, B | 1 |
| Livingstone, LR | 1 |
| Sprouse, J | 1 |
| Jacks, T | 1 |
| Yin, Y | 1 |
| Tainsky, MA | 1 |
| Bischoff, FZ | 1 |
| Strong, LC | 1 |
| Wahl, GM | 1 |
1 review available for phosphonoacetic acid and Li-Fraumeni Syndrome
| Article | Year |
|---|---|
Genomic integrity and the genetics of cancer.
Topics: Adenovirus E1A Proteins; Adenoviruses, Human; Antimetabolites; Apoptosis; Aspartic Acid; Cell Cycle; | 1994 |
2 other studies available for phosphonoacetic acid and Li-Fraumeni Syndrome
| Article | Year |
|---|---|
Altered cell cycle arrest and gene amplification potential accompany loss of wild-type p53.
Topics: Animals; Aspartate Carbamoyltransferase; Aspartic Acid; Base Sequence; Carbamoyl-Phosphate Synthase | 1992 |
Wild-type p53 restores cell cycle control and inhibits gene amplification in cells with mutant p53 alleles.
Topics: Aspartic Acid; Base Sequence; Cell Cycle; Chromosome Deletion; Fibroblasts; G1 Phase; Gene Amplifica | 1992 |