phosphonoacetic acid has been researched along with Leukemia L 1210 in 15 studies
Phosphonoacetic Acid: A simple organophosphorus compound that inhibits DNA polymerase, especially in viruses and is used as an antiviral agent.
phosphonoacetic acid : A member of the class of phosphonic acids that is phosphonic acid in which the hydrogen attached to the phosphorous is replaced by a carboxymethyl group.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Phosphonoacetic acid has been shown to suppress replication of DNA tumor viruses by inhibiting the activity of virus-induced DNA polymerase and consequently viral DNA synthesis." | 1.26 | Inhibition of activities of DNA polymerase alpha, beta, gamma, and reverse transcriptase of L1210 cells by phosphonoacetic acid. ( Allaudeen, HS; Bertino, JR, 1978) |
| "Another solid tumor, Ridgway osteogenic sarcoma, which is sensitivie to many established chemotherapeutic agents, did not respond to PALA." | 1.26 | Antitumor activity of N-(phosphonacetyl)-L-aspartic acid, a transition-state inhibitor of aspartate transcarbamylase. ( Goldin, A; Inouye, T; Johnson, RK; Stark, GR, 1976) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 11 (73.33) | 18.7374 |
| 1990's | 3 (20.00) | 18.2507 |
| 2000's | 1 (6.67) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Pfund, E | 1 |
| Lequeux, T | 1 |
| Masson, S | 1 |
| Vazeux, M | 1 |
| Cordi, A | 1 |
| Pierre, A | 1 |
| Serre, V | 1 |
| Hervé, G | 1 |
| Grant, S | 1 |
| Rauscher, F | 1 |
| Jakubowski, A | 1 |
| Cadman, E | 1 |
| Karle, JM | 1 |
| Anderson, LW | 2 |
| Cysyk, RL | 2 |
| Monks, A | 1 |
| Strong, J | 1 |
| Moyer, JD | 2 |
| Smith, PA | 1 |
| Levy, EJ | 1 |
| Handschumacher, RE | 2 |
| Loh, E | 1 |
| Kufe, DW | 1 |
| Kinahan, JJ | 1 |
| Kowal, EP | 1 |
| Grindey, GB | 1 |
| van Laar, JA | 1 |
| Durrani, FA | 1 |
| Rustum, YM | 1 |
| Cory, AH | 1 |
| Cory, JG | 1 |
| Allaudeen, HS | 1 |
| Bertino, JR | 1 |
| Johnson, RK | 1 |
| Inouye, T | 1 |
| Goldin, A | 1 |
| Stark, GR | 1 |
| Hollis, LS | 1 |
| Miller, AV | 1 |
| Amundsen, AR | 1 |
| Schurig, JE | 1 |
| Stern, EW | 1 |
| Vaghefi, MM | 1 |
| McKernan, PA | 1 |
| Robins, RK | 1 |
| Stolfi, RL | 1 |
| Sawyer, RC | 1 |
| Martin, DS | 1 |
15 other studies available for phosphonoacetic acid and Leukemia L 1210
| Article | Year |
|---|---|
Efficient synthesis of fluorothiosparfosic acid analogues with potential antitumoral activity.
Topics: Animals; Antineoplastic Agents; Aspartate Carbamoyltransferase; Aspartic Acid; Drug Screening Assays | 2005 |
Effect of N-(phosphonacetyl)-L-aspartate on 5-azacytidine metabolism in P388 and L1210 cells.
Topics: Animals; Aspartate Carbamoyltransferase; Aspartic Acid; Azacitidine; Cell Division; Cytidine; DNA, N | 1981 |
Effect of plasma concentrations of uridine on pyrimidine biosynthesis in cultured L1210 cells.
Topics: Animals; Aspartic Acid; Bicarbonates; Culture Media; Leukemia L1210; Mice; Phosphonoacetic Acid; Pyr | 1984 |
Flux through the de novo pyrimidine pathway in vivo. Effect of N-phosphonacetyl-L-aspartate, a potent inhibitor of aspartate transcarbamylase.
Topics: Animals; Antimetabolites, Antineoplastic; Aspartate Carbamoyltransferase; Aspartic Acid; Carbon Diox | 1983 |
Kinetics of N-(phosphonacetyl)-L-aspartate and pyrazofurin depletion of pyrimidine ribonucleotide and deoxyribonucleotide pools and their relationship to nucleic acid synthesis in intact and permeabilized cells.
Topics: Amides; Animals; Antimetabolites, Antineoplastic; Aspartic Acid; Deoxyribonucleotides; DNA Replicati | 1982 |
Synergistic effects with inhibitors of de novo pyrimidine synthesis, acivicin, and N-(phosphonacetyl)-L-aspartic acid.
Topics: Animals; Aspartic Acid; Cells, Cultured; Chromatography, High Pressure Liquid; Deoxycytosine Nucleot | 1981 |
Biochemical and antitumor effects of the combination of thymidine and 1-beta-D-arabinofuranosylcytosine against leukemia L1210.
Topics: Animals; Arabinofuranosylcytosine Triphosphate; Aspartic Acid; Cells, Cultured; Cytarabine; Cytidine | 1981 |
Antitumor activity of the weekly intravenous push schedule of 5-fluoro-2'-deoxyuridine +/- N-phosphonacetyl-L-aspartate in mice bearing advanced colon carcinoma 26.
Topics: Animals; Antineoplastic Agents; Aspartic Acid; Colonic Neoplasms; Cytidine Triphosphate; Dose-Respon | 1993 |
Cellular responses in mouse leukemia L1210 cells made resistant to deoxyadenosine.
Topics: Animals; Apoptosis; Aspartic Acid; Deoxyadenine Nucleotides; Deoxyadenosines; Drug Resistance; Guano | 1998 |
Inhibition of activities of DNA polymerase alpha, beta, gamma, and reverse transcriptase of L1210 cells by phosphonoacetic acid.
Topics: Animals; Cell Division; Cell Line; DNA; Kinetics; Leukemia L1210; Nucleic Acid Synthesis Inhibitors; | 1978 |
Selective inhibition of pyrimidine synthesis and depletion of nucleotide pools by N-(phosphonacetyl)-L-aspartate.
Topics: Animals; Aspartic Acid; Cells, Cultured; Female; Leukemia L1210; Lung Neoplasms; Mice; Mice, Inbred | 1979 |
Antitumor activity of N-(phosphonacetyl)-L-aspartic acid, a transition-state inhibitor of aspartate transcarbamylase.
Topics: Animals; Antineoplastic Agents; Aspartate Carbamoyltransferase; Aspartic Acid; Carbamyl Phosphate; D | 1976 |
cis-diamineplatinum (II) complexes containing phosphono carboxylate ligands as antitumor agents.
Topics: Animals; Antineoplastic Agents; Chemical Phenomena; Chemistry; Chromatography, High Pressure Liquid; | 1990 |
Synthesis and antiviral activity of certain nucleoside 5'-phosphonoformate derivatives.
Topics: Animals; Antiviral Agents; Cell Line; Chlorocebus aethiops; Deltaretrovirus; Foscarnet; Hydrogen-Ion | 1986 |
Failure of L-histidinol to improve the therapeutic efficiency of 5-fluorouracil against murine breast tumors.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Aspartic Acid; Cell Cycle; Female; Fluorour | 1987 |