phosphonoacetic acid has been researched along with Fibrosarcoma in 4 studies
Phosphonoacetic Acid: A simple organophosphorus compound that inhibits DNA polymerase, especially in viruses and is used as an antiviral agent.
phosphonoacetic acid : A member of the class of phosphonic acids that is phosphonic acid in which the hydrogen attached to the phosphorous is replaced by a carboxymethyl group.
Fibrosarcoma: A sarcoma derived from deep fibrous tissue, characterized by bundles of immature proliferating fibroblasts with variable collagen formation, which tends to invade locally and metastasize by the bloodstream. (Stedman, 25th ed)
| Excerpt | Relevance | Reference |
|---|---|---|
| " The studies reported here assess whether p53 deficiency leads to spontaneous genetic instability by comparing cell cycle responses and amplification frequencies of the human fibrosarcoma cell line HT1080 when treated with PALA or with methotrexate, an antifolate that, under the conditions used, should not generate DNA breaks." | 3.70 | Gene amplification in a p53-deficient cell line requires cell cycle progression under conditions that generate DNA breakage. ( Almasan, A; Brody, LL; Paulson, TG; Wahl, GM, 1998) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (25.00) | 18.7374 |
| 1990's | 3 (75.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Jonczyk, P | 1 |
| White, A | 1 |
| Lum, K | 1 |
| Barrett, JC | 1 |
| Tlsty, TD | 1 |
| Paulson, TG | 1 |
| Almasan, A | 1 |
| Brody, LL | 1 |
| Wahl, GM | 1 |
| Shimura, M | 1 |
| Onozuka, Y | 1 |
| Yamaguchi, T | 1 |
| Hatake, K | 1 |
| Takaku, F | 1 |
| Ishizaka, Y | 1 |
| Cillo, C | 1 |
| Ling, V | 1 |
| Hill, RP | 1 |
4 other studies available for phosphonoacetic acid and Fibrosarcoma
| Article | Year |
|---|---|
Amplification potential in preneoplastic and neoplastic Syrian hamster embryo fibroblasts transformed by various carcinogens.
Topics: Animals; Antineoplastic Agents; Aspartic Acid; Carcinogens; Cell Transformation, Neoplastic; Cell Tr | 1993 |
Gene amplification in a p53-deficient cell line requires cell cycle progression under conditions that generate DNA breakage.
Topics: Aspartic Acid; Cell Cycle; Cell Cycle Proteins; DNA Damage; Drug Resistance; Fibrosarcoma; Gene Ampl | 1998 |
Micronuclei formation with chromosome breaks and gene amplification caused by Vpr, an accessory gene of human immunodeficiency virus.
Topics: Aneuploidy; Aspartate Carbamoyltransferase; Aspartic Acid; Carbamoyl-Phosphate Synthase (Glutamine-H | 1999 |
Drug resistance in KHT fibrosarcoma cell lines with different metastatic ability.
Topics: Animals; Antineoplastic Agents; Aspartic Acid; Cell Line; Drug Resistance; Fibrosarcoma; Gene Amplif | 1989 |