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phosphonoacetic acid and Eye Infections, Viral

phosphonoacetic acid has been researched along with Eye Infections, Viral in 22 studies

Phosphonoacetic Acid: A simple organophosphorus compound that inhibits DNA polymerase, especially in viruses and is used as an antiviral agent.
phosphonoacetic acid : A member of the class of phosphonic acids that is phosphonic acid in which the hydrogen attached to the phosphorous is replaced by a carboxymethyl group.

Eye Infections, Viral: Infections of the eye caused by minute intracellular agents. These infections may lead to severe inflammation in various parts of the eye - conjunctiva, iris, eyelids, etc. Several viruses have been identified as the causative agents. Among these are Herpesvirus, Adenovirus, Poxvirus, and Myxovirus.

Research Excerpts

ExcerptRelevanceReference
"In a controlled trial of foscarnet in the treatment of cytomegalovirus (CMV) retinitis in patients with the acquired immunodeficiency syndrome (AIDS), patients with non-immediately sight-threatening lesions were randomized to receive immediate treatment with foscarnet or foscarnet treatment delayed until the first signs of retinitis progression."9.07Design of a randomized controlled trial of foscarnet in patients with cytomegalovirus retinitis associated with acquired immunodeficiency syndrome. ( Polis, MA, 1992)
"To evaluate foscarnet sodium in treating cytomegalovirus retinitis in patients with AIDS."9.07A randomized, controlled trial of foscarnet in the treatment of cytomegalovirus retinitis in patients with AIDS. ( Baird, BF; Davey, RT; Davis, M; De Smet, MD; Falloon, J; Kovacs, JA; Palestine, AG; Polis, MA; Zunich, KM; Zurlo, JJ, 1991)
"The use of ganciclovir in the treatment of cytomegalovirus (CMV) retinitis in patients with acquired immunodeficiency syndrome (AIDS) is limited by marrow toxicity and by the development of resistance to this agent in CMV strains capable of causing progressive disease."8.78Maintenance therapy for cytomegalovirus retinitis in patients with acquired immunodeficiency syndrome: foscarnet. ( Jacobson, MA, 1992)
"Infections caused by cytomegalovirus (CMV) resistant in vitro to ganciclovir, defined as requiring greater than 6 mumols of ganciclovir for ED50 have developed in some AIDS patients with progressive CMV retinitis despite chronic ganciclovir therapy."7.68Foscarnet therapy for ganciclovir-resistant cytomegalovirus retinitis in patients with AIDS. ( Drew, WL; Feinberg, J; Jacobson, MA; Miner, RD; O'Donnell, JJ; Parenti, D; Whitmore, PV, 1991)
"Foscarnet is an investigational antiviral agent that has been used effectively in the treatment of cytomegalovirus (CMV) retinitis in AIDS patients."7.68Successful foscarnet therapy for cytomegalovirus retinitis in an AIDS patient undergoing hemodialysis: rationale for empiric dosing and plasma level monitoring. ( Gambertoglio, JG; Graziani, AL; Grunwald, JE; MacGregor, RR; Weiss, R, 1991)
"Foscarnet has a low solubility and a high degree of ionization at physiologic pH, requiring it to be administered in higher doses and larger volumes."6.38Approaches to the treatment of cytomegalovirus retinitis: ganciclovir and foscarnet. ( Jacobson, MA; O'Donnell, JJ, 1991)
"In a controlled trial of foscarnet in the treatment of cytomegalovirus (CMV) retinitis in patients with the acquired immunodeficiency syndrome (AIDS), patients with non-immediately sight-threatening lesions were randomized to receive immediate treatment with foscarnet or foscarnet treatment delayed until the first signs of retinitis progression."5.07Design of a randomized controlled trial of foscarnet in patients with cytomegalovirus retinitis associated with acquired immunodeficiency syndrome. ( Polis, MA, 1992)
"To evaluate foscarnet sodium in treating cytomegalovirus retinitis in patients with AIDS."5.07A randomized, controlled trial of foscarnet in the treatment of cytomegalovirus retinitis in patients with AIDS. ( Baird, BF; Davey, RT; Davis, M; De Smet, MD; Falloon, J; Kovacs, JA; Palestine, AG; Polis, MA; Zunich, KM; Zurlo, JJ, 1991)
"The use of ganciclovir in the treatment of cytomegalovirus (CMV) retinitis in patients with acquired immunodeficiency syndrome (AIDS) is limited by marrow toxicity and by the development of resistance to this agent in CMV strains capable of causing progressive disease."4.78Maintenance therapy for cytomegalovirus retinitis in patients with acquired immunodeficiency syndrome: foscarnet. ( Jacobson, MA, 1992)
"Infections caused by cytomegalovirus (CMV) resistant in vitro to ganciclovir, defined as requiring greater than 6 mumols of ganciclovir for ED50 have developed in some AIDS patients with progressive CMV retinitis despite chronic ganciclovir therapy."3.68Foscarnet therapy for ganciclovir-resistant cytomegalovirus retinitis in patients with AIDS. ( Drew, WL; Feinberg, J; Jacobson, MA; Miner, RD; O'Donnell, JJ; Parenti, D; Whitmore, PV, 1991)
"Foscarnet is an investigational antiviral agent that has been used effectively in the treatment of cytomegalovirus (CMV) retinitis in AIDS patients."3.68Successful foscarnet therapy for cytomegalovirus retinitis in an AIDS patient undergoing hemodialysis: rationale for empiric dosing and plasma level monitoring. ( Gambertoglio, JG; Graziani, AL; Grunwald, JE; MacGregor, RR; Weiss, R, 1991)
"Foscarnet has a low solubility and a high degree of ionization at physiologic pH, requiring it to be administered in higher doses and larger volumes."2.38Approaches to the treatment of cytomegalovirus retinitis: ganciclovir and foscarnet. ( Jacobson, MA; O'Donnell, JJ, 1991)
" Myelosuppression may be further exacerbated in AIDS patients by such other agents as zidovudine or trimethoprim/sulfamethoxazole, often necessitating dosage reductions or discontinuation of these agents in patients receiving ganciclovir."2.38Foscarnet sodium. ( Baltz, JK; Minor, JR, 1991)

Research

Studies (22)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's22 (100.00)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Healy, B1
Masur, H1
Heinemann, MH1
Polis, MA2
Jacobson, MA4
Jabs, DA1
Salit, IE1
Wilson, RJ1
Morris, DJ1
Drew, WL1
Feinberg, J1
O'Donnell, JJ2
Whitmore, PV1
Miner, RD1
Parenti, D1
MacGregor, RR1
Graziani, AL1
Weiss, R1
Grunwald, JE1
Gambertoglio, JG1
Palestine, AG1
De Smet, MD1
Baird, BF1
Falloon, J1
Kovacs, JA1
Davey, RT1
Zurlo, JJ1
Zunich, KM1
Davis, M1
Marwick, C1
Nightingale, SL1
Nelson, MR1
Barter, G1
Hawkins, D1
Gazzard, BG1
Henderly, DE1
Jampol, LM1
Minor, JR1
Baltz, JK1
Farese, RV1
Schambelan, M1
Hollander, H1
Stringari, S1
Deray, G1
Katlama, C1
Dohin, E1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
A Phase II Dose-Ranging, Open-Labelled Trial of Foscarnet Salvage Therapy for AIDS Patients With Sight-Threatening CMV Retinitis Who Cannot Be Treated With Ganciclovir Due To Myelosuppression or Treatment Failure[NCT00000691]Phase 2156 participants InterventionalCompleted
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

6 reviews available for phosphonoacetic acid and Eye Infections, Viral

ArticleYear
Characteristics of cytomegalovirus retinitis in patients with acquired immunodeficiency syndrome.
    The American journal of medicine, 1992, Feb-14, Volume: 92, Issue:2A

    Topics: Acquired Immunodeficiency Syndrome; Antiviral Agents; Cytomegalovirus Infections; Eye Infections, Vi

1992
Maintenance therapy for cytomegalovirus retinitis in patients with acquired immunodeficiency syndrome: foscarnet.
    The American journal of medicine, 1992, Feb-14, Volume: 92, Issue:2A

    Topics: Antiviral Agents; Cytomegalovirus Infections; Drug Therapy, Combination; Eye Infections, Viral; Fosc

1992
Cytomegalovirus retinitis in AIDS.
    Journal of the American Optometric Association, 1992, Volume: 63, Issue:1

    Topics: Acquired Immunodeficiency Syndrome; Antiviral Agents; Cytomegalovirus Infections; Diagnosis, Differe

1992
Approaches to the treatment of cytomegalovirus retinitis: ganciclovir and foscarnet.
    Journal of acquired immune deficiency syndromes, 1991, Volume: 4 Suppl 1

    Topics: Antiviral Agents; Cytomegalovirus Infections; Drug Therapy, Combination; Eye Infections, Viral; Fosc

1991
Diagnosis and treatment of cytomegalovirus retinitis.
    Journal of acquired immune deficiency syndromes, 1991, Volume: 4 Suppl 1

    Topics: Antiviral Agents; Cytomegalovirus Infections; Diagnosis, Differential; Eye Infections, Viral; Foscar

1991
Foscarnet sodium.
    DICP : the annals of pharmacotherapy, 1991, Volume: 25, Issue:1

    Topics: Acquired Immunodeficiency Syndrome; Antiviral Agents; Cytomegalovirus Infections; Eye Infections, Vi

1991

Trials

2 trials available for phosphonoacetic acid and Eye Infections, Viral

ArticleYear
Design of a randomized controlled trial of foscarnet in patients with cytomegalovirus retinitis associated with acquired immunodeficiency syndrome.
    The American journal of medicine, 1992, Feb-14, Volume: 92, Issue:2A

    Topics: Acquired Immunodeficiency Syndrome; Adult; Antiviral Agents; Cytomegalovirus Infections; Eye Infecti

1992
A randomized, controlled trial of foscarnet in the treatment of cytomegalovirus retinitis in patients with AIDS.
    Annals of internal medicine, 1991, Nov-01, Volume: 115, Issue:9

    Topics: Acquired Immunodeficiency Syndrome; Adult; Antiviral Agents; Cytomegalovirus Infections; Eye Infecti

1991

Other Studies

14 other studies available for phosphonoacetic acid and Eye Infections, Viral

ArticleYear
From the National Institutes of Health.
    JAMA, 1992, Jan-08, Volume: 267, Issue:2

    Topics: Acquired Immunodeficiency Syndrome; Anti-Inflammatory Agents, Non-Steroidal; Antiviral Agents; Arthr

1992
Foscarnet.
    The Medical letter on drugs and therapeutics, 1992, Jan-10, Volume: 34, Issue:861

    Topics: Acquired Immunodeficiency Syndrome; Antiviral Agents; Cytomegalovirus Infections; Eye Infections, Vi

1992
Clinical implications of herpesvirus infections in patients with AIDS. Introduction.
    The American journal of medicine, 1992, Feb-14, Volume: 92, Issue:2A

    Topics: Acquired Immunodeficiency Syndrome; Antiviral Agents; Cytomegalovirus Infections; Eye Infections, Vi

1992
Treatment of cytomegalovirus retinitis--1992.
    Archives of ophthalmology (Chicago, Ill. : 1960), 1992, Volume: 110, Issue:2

    Topics: Acquired Immunodeficiency Syndrome; Antiviral Agents; Cytomegalovirus Infections; Eye Infections, Vi

1992
Why was treatment of cytomegalovirus retinitis randomized?
    Annals of internal medicine, 1992, Apr-01, Volume: 116, Issue:7

    Topics: Antiviral Agents; Cytomegalovirus Infections; Eye Infections, Viral; Foscarnet; Ganciclovir; Humans;

1992
Treatment of CMV retinitis.
    Lancet (London, England), 1992, Jan-25, Volume: 339, Issue:8787

    Topics: Acquired Immunodeficiency Syndrome; Antiviral Agents; Cytomegalovirus Infections; Eye Infections, Vi

1992
Foscarnet therapy for ganciclovir-resistant cytomegalovirus retinitis in patients with AIDS.
    The Journal of infectious diseases, 1991, Volume: 163, Issue:6

    Topics: Acquired Immunodeficiency Syndrome; Adult; Antiviral Agents; Cytomegalovirus; Cytomegalovirus Infect

1991
Successful foscarnet therapy for cytomegalovirus retinitis in an AIDS patient undergoing hemodialysis: rationale for empiric dosing and plasma level monitoring.
    The Journal of infectious diseases, 1991, Volume: 164, Issue:4

    Topics: Acquired Immunodeficiency Syndrome; Acute Kidney Injury; Adult; Antiviral Agents; Cytomegalovirus In

1991
National Eye Institute issues clinical alert about CMV retinitis in AIDS.
    JAMA, 1991, Nov-20, Volume: 266, Issue:19

    Topics: Acquired Immunodeficiency Syndrome; Antiviral Agents; Cytomegalovirus Infections; Eye Infections, Vi

1991
From the Food and Drug Administration.
    JAMA, 1991, Dec-18, Volume: 266, Issue:23

    Topics: Acquired Immunodeficiency Syndrome; Antiviral Agents; Cytomegalovirus Infections; Eye Infections, Vi

1991
Simultaneous treatment of cytomegalovirus retinitis with ganciclovir and foscarnet.
    Lancet (London, England), 1991, Jul-27, Volume: 338, Issue:8761

    Topics: Acquired Immunodeficiency Syndrome; Adult; Antiviral Agents; Cytomegalovirus Infections; Eye Infecti

1991
Seeing the way forward for treatment of CMV retinitis.
    Lancet (London, England), 1991, Dec-14, Volume: 338, Issue:8781

    Topics: Acquired Immunodeficiency Syndrome; Antiviral Agents; Clinical Trials as Topic; Cytomegalovirus Infe

1991
Nephrogenic diabetes insipidus associated with foscarnet treatment of cytomegalovirus retinitis.
    Annals of internal medicine, 1990, Jun-15, Volume: 112, Issue:12

    Topics: Acquired Immunodeficiency Syndrome; Adult; Antiviral Agents; Cytomegalovirus Infections; Diabetes In

1990
Prevention of foscarnet nephrotoxicity.
    Annals of internal medicine, 1990, Aug-15, Volume: 113, Issue:4

    Topics: Adult; Antiviral Agents; Cytomegalovirus Infections; Eye Infections, Viral; Female; Fluid Therapy; F

1990