phosphonoacetic acid has been researched along with Experimental Mammary Neoplasms in 12 studies
Phosphonoacetic Acid: A simple organophosphorus compound that inhibits DNA polymerase, especially in viruses and is used as an antiviral agent.
phosphonoacetic acid : A member of the class of phosphonic acids that is phosphonic acid in which the hydrogen attached to the phosphorous is replaced by a carboxymethyl group.
| Excerpt | Relevance | Reference |
|---|---|---|
| " The extent of control of the EMT-6 mammary adenocarcinoma was determined using fractionated radiation (12 irradiations) over a 3-week period using the radiosensitizer 5-chloro-2'-deoxycytidine (CldC) and biomodulators of its metabolism: N-(Phosphonacetyl)-L-aspartate (PALA), tetrahydrouridine and 5-fluoro-2'-deoxycytidine (FdC)." | 3.69 | Five-chlorodeoxycytidine and biomodulators of its metabolism result in fifty to eighty percent cures of advanced EMT-6 tumors when used with fractionated radiation. ( Greer, S; Marion, HS; Schwade, J, 1995) |
| " Using such low, nontherapeutic, but biochemically active doses of PALA in combination with 5-fluorouracil (FUra(, it was possible to maintain the dose of FUra at its full maximum tolerated single agent dose." | 1.27 | Therapeutic utility of utilizing low doses of N-(phosphonacetyl)-L-aspartic acid in combination with 5-fluorouracil: a murine study with clinical relevance. ( Casper, ES; Martin, DS; Sawyer, RC; Spiegelman, S; Stolfi, RL; Young, CW, 1983) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (41.67) | 18.7374 |
| 1990's | 7 (58.33) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Martin, DS | 9 |
| Stolfi, RL | 7 |
| Sawyer, RC | 2 |
| Spiegelman, S | 1 |
| Casper, ES | 1 |
| Young, CW | 1 |
| Greer, S | 1 |
| Schwade, J | 1 |
| Marion, HS | 1 |
| Colofiore, JR | 5 |
| Nord, LD | 5 |
| Sternberg, S | 1 |
| Mahmood, U | 1 |
| Street, JC | 1 |
| Matei, C | 1 |
| Ballon, D | 1 |
| Koutcher, JA | 3 |
| Alfieri, AA | 1 |
| Netto, G | 1 |
| Reuter, V | 1 |
| Sternberg, SS | 1 |
| Akazawa, S | 1 |
| Kumai, R | 1 |
| Shimizu, K | 1 |
| Ayusawa, D | 1 |
| Seno, T | 1 |
| Yoshida, S | 1 |
| Sluyser, M | 1 |
| Evers, SG | 1 |
| de Goeij, CC | 1 |
12 other studies available for phosphonoacetic acid and Experimental Mammary Neoplasms
| Article | Year |
|---|---|
Therapeutic utility of utilizing low doses of N-(phosphonacetyl)-L-aspartic acid in combination with 5-fluorouracil: a murine study with clinical relevance.
Topics: Animals; Aspartic Acid; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Drug Synergi | 1983 |
Five-chlorodeoxycytidine and biomodulators of its metabolism result in fifty to eighty percent cures of advanced EMT-6 tumors when used with fractionated radiation.
Topics: Adenocarcinoma; Animals; Aspartic Acid; Body Weight; Deoxycytidine; Idoxuridine; Mammary Neoplasms, | 1995 |
Biochemical modulation of tumor cell energy in vivo: II. A lower dose of adriamycin is required and a greater antitumor activity is induced when cellular energy is depressed.
Topics: 6-Aminonicotinamide; Animals; Apoptosis; Aspartic Acid; Dose-Response Relationship, Drug; Doxorubici | 1994 |
Correlation of retention of tumor methylmercaptopurine riboside-5'-phosphate with effectiveness in CD8F1 murine mammary tumor regression.
Topics: 6-Aminonicotinamide; Adenosine Kinase; Adenosine Triphosphate; Animals; Antineoplastic Combined Chem | 1996 |
In vivo detection by 31P NMR of pentose phosphate pathway block secondary to biochemical modulation.
Topics: 6-Aminonicotinamide; Animals; Antineoplastic Combined Chemotherapy Protocols; Aspartic Acid; Cell Di | 1996 |
Marked enhancement in vivo of paclitaxel's (taxol's) tumor-regressing activity by ATP-depleting modulation.
Topics: 6-Aminonicotinamide; Animals; Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherap | 1996 |
Apoptosis induced in advanced CD8F1-murine mammary tumors by the combination of PALA, MMPR and 6AN precedes tumor regression and is preceded by ATP depletion.
Topics: 6-Aminonicotinamide; Adenosine Triphosphate; Animals; Antimetabolites, Antineoplastic; Antineoplasti | 1997 |
Biochemical modulation of tumor cell energy: regression of advanced spontaneous murine breast tumors with a 5-fluorouracil-containing drug combination.
Topics: 6-Aminonicotinamide; Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; | 1992 |
Failure of L-histidinol to improve the therapeutic efficiency of 5-fluorouracil against murine breast tumors.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Aspartic Acid; Cell Cycle; Female; Fluorour | 1987 |
Cancer chemotherapy: past is prologue.
Topics: 6-Aminonicotinamide; Animals; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy | 1985 |
[Biochemical modulation of 5-FU by thymidine and N-phosphoacetyl-L-aspartate: the relation between 5-FU incorporation into RNA and its cytocidal effect].
Topics: Animals; Aspartic Acid; Cell Division; Cell Survival; Cells, Cultured; DNA, Neoplasm; Drug Synergism | 1986 |
Chemotherapy and hormonal therapy of mouse mammary tumors.
Topics: Animals; Aspartic Acid; Body Weight; Cholesterol; Cisplatin; Delayed-Action Preparations; Doxorubici | 1985 |