phosphonoacetic acid has been researched along with Experimental Leukemia in 6 studies
Phosphonoacetic Acid: A simple organophosphorus compound that inhibits DNA polymerase, especially in viruses and is used as an antiviral agent.
phosphonoacetic acid : A member of the class of phosphonic acids that is phosphonic acid in which the hydrogen attached to the phosphorous is replaced by a carboxymethyl group.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Tiazofurin is a synthetic "C" nucleoside analogue with a promising spectrum of experimental antitumor activity and a relatively novel mechanism of action." | 1.27 | Therapeutic synergism of tiazofurin and selected antitumor drugs against sensitive and resistant P388 leukemia in mice. ( Harrison, SD; O'Dwyer, PJ; Trader, MW, 1986) |
| "Another solid tumor, Ridgway osteogenic sarcoma, which is sensitivie to many established chemotherapeutic agents, did not respond to PALA." | 1.26 | Antitumor activity of N-(phosphonacetyl)-L-aspartic acid, a transition-state inhibitor of aspartate transcarbamylase. ( Goldin, A; Inouye, T; Johnson, RK; Stark, GR, 1976) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 6 (100.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Grant, S | 2 |
| Rauscher, F | 1 |
| Jakubowski, A | 1 |
| Cadman, E | 1 |
| Ardalan, B | 1 |
| Jayaram, HN | 1 |
| Johnson, RK | 3 |
| Swyryd, EA | 1 |
| Stark, GR | 2 |
| Inouye, T | 1 |
| Goldin, A | 1 |
| Bhalla, K | 1 |
| Harrison, SD | 1 |
| O'Dwyer, PJ | 1 |
| Trader, MW | 1 |
6 other studies available for phosphonoacetic acid and Experimental Leukemia
| Article | Year |
|---|---|
Effect of N-(phosphonacetyl)-L-aspartate on 5-azacytidine metabolism in P388 and L1210 cells.
Topics: Animals; Aspartate Carbamoyltransferase; Aspartic Acid; Azacitidine; Cell Division; Cytidine; DNA, N | 1981 |
Collateral sensitivity to N-(phosphonacetyl)-L-aspartic acid in a line of P388 leukemia cells selected for resistance to L-(alpha S, 5S)-alpha-amino-3- chloro-4,5-dihydro-5-isoxazoleacetic acid (acivicin).
Topics: Adenine Phosphoribosyltransferase; Animals; Antibiotics, Antineoplastic; Antimetabolites, Antineopla | 1983 |
Effects of N-(phosphonacetyl)-L-aspartate on murine tumors and normal tissues in vivo and in vitro and the relationship of sensitivity to rate of proliferation and level of aspartate transcarbamylase.
Topics: Animals; Antimetabolites, Antineoplastic; Aspartate Carbamoyltransferase; Aspartic Acid; Cells, Cult | 1978 |
Antitumor activity of N-(phosphonacetyl)-L-aspartic acid, a transition-state inhibitor of aspartate transcarbamylase.
Topics: Animals; Antineoplastic Agents; Aspartate Carbamoyltransferase; Aspartic Acid; Carbamyl Phosphate; D | 1976 |
Effect of deoxycytidine on the in vitro response of human leukemia cells to inhibitors of de novo pyrimidine biosynthesis.
Topics: 3-Deazauridine; Amides; Aspartic Acid; Cell Division; Cell Line; Deoxycytidine; Deoxycytidine Kinase | 1987 |
Therapeutic synergism of tiazofurin and selected antitumor drugs against sensitive and resistant P388 leukemia in mice.
Topics: Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Aspartic Acid; Cispl | 1986 |