phosphonoacetic acid has been researched along with Disease Models, Animal in 14 studies
Phosphonoacetic Acid: A simple organophosphorus compound that inhibits DNA polymerase, especially in viruses and is used as an antiviral agent.
phosphonoacetic acid : A member of the class of phosphonic acids that is phosphonic acid in which the hydrogen attached to the phosphorous is replaced by a carboxymethyl group.
Disease Models, Animal: Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Phosphonoacetic acid (PAA) was evaluated as therapy for primary cutaneous herpes simplex virus (HSV) infections in guinea pigs." | 7.66 | Topical phosphonoacetic acid treatment of cutaneous herpes simplex infections in the guinea pig. ( Jarratt, MT; McCarty, JR, 1979) |
| " A MeOH extract of Symphyocladia latiuscula (Rhodomelaceae) and its fractions exhibited antiviral activities against acyclovir (ACV) and phosphonoacetic acid (PAA)-resistant (AP(r)) herpes simplex type 1 (HSV-1), thymidine kinase (TK(-)) deficient HSV-1 and wild type HSV-1 in vitro without cytotoxicity." | 3.73 | Antiviral activity of the marine alga Symphyocladia latiuscula against herpes simplex virus (HSV-1) in vitro and its therapeutic efficacy against HSV-1 infection in mice. ( Choi, JS; Hattori, M; Kurokawa, M; Nakamura, N; Park, HJ; Shiraki, K, 2005) |
| "The herpesvirus DNA polymerase inhibitor foscarnet, applied topically, and the anti-herpesvirus guanosine analogue buciclovir, given orally, decreased virus replication and disease development in primary skin infections of mice caused by herpes simplex virus type 1 (HSV-1)." | 3.67 | Limited efficacy of inhibitors of herpes simplex virus DNA synthesis in murine models of recrudescent disease. ( Datema, R; Ericson, AC; Kristofferson, A; Sohl-Akerlund, A, 1988) |
| "Phosphonoacetic acid (PAA) was evaluated as therapy for primary cutaneous herpes simplex virus (HSV) infections in guinea pigs." | 3.66 | Topical phosphonoacetic acid treatment of cutaneous herpes simplex infections in the guinea pig. ( Jarratt, MT; McCarty, JR, 1979) |
| "Reversible encephalopathy was observed in 6 (7." | 1.26 | Neurotoxicity of the pyrimidine synthesis inhibitor N-phosphonoacetyl-L-aspartate. ( Casper, ES; Gralla, RJ; Kemeny, N; Wiley, RG, 1982) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 11 (78.57) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (7.14) | 29.6817 |
| 2010's | 1 (7.14) | 24.3611 |
| 2020's | 1 (7.14) | 2.80 |
| Authors | Studies |
|---|---|
| Solinski, HJ | 1 |
| Dranchak, P | 1 |
| Oliphant, E | 1 |
| Gu, X | 1 |
| Earnest, TW | 1 |
| Braisted, J | 1 |
| Inglese, J | 1 |
| Hoon, MA | 1 |
| Abrams, RPM | 1 |
| Yasgar, A | 1 |
| Teramoto, T | 1 |
| Lee, MH | 1 |
| Dorjsuren, D | 1 |
| Eastman, RT | 1 |
| Malik, N | 1 |
| Zakharov, AV | 1 |
| Li, W | 1 |
| Bachani, M | 1 |
| Brimacombe, K | 1 |
| Steiner, JP | 1 |
| Hall, MD | 1 |
| Balasubramanian, A | 1 |
| Jadhav, A | 1 |
| Padmanabhan, R | 1 |
| Simeonov, A | 1 |
| Nath, A | 1 |
| Park, HJ | 1 |
| Kurokawa, M | 1 |
| Shiraki, K | 1 |
| Nakamura, N | 1 |
| Choi, JS | 1 |
| Hattori, M | 1 |
| Arvin, AM | 1 |
| Martin, DP | 1 |
| Gard, EA | 1 |
| Merigan, TC | 1 |
| Lucia, HL | 1 |
| Griffith, BP | 1 |
| Hsiung, GD | 1 |
| Wiley, RG | 1 |
| Gralla, RJ | 1 |
| Casper, ES | 1 |
| Kemeny, N | 1 |
| Aoki, FY | 1 |
| Trépanier, G | 1 |
| Lussier, G | 1 |
| McCarty, JR | 1 |
| Jarratt, MT | 1 |
| Streissle, G | 1 |
| Kung, HF | 1 |
| Ackerhalt, R | 1 |
| Blau, M | 1 |
| Debs, RJ | 1 |
| Montgomery, AB | 1 |
| Brunette, EN | 1 |
| DeBruin, M | 1 |
| Shanley, JD | 1 |
| Kristofferson, A | 1 |
| Ericson, AC | 2 |
| Sohl-Akerlund, A | 1 |
| Datema, R | 2 |
| Ulbricht, A | 1 |
| Färber, I | 1 |
| Wutzler, P | 1 |
| van Genderen, J | 1 |
| Wolthuis, OL | 1 |
| Ariens, AT | 1 |
14 other studies available for phosphonoacetic acid and Disease Models, Animal
| Article | Year |
|---|---|
Inhibition of natriuretic peptide receptor 1 reduces itch in mice.
Topics: Animals; Behavior, Animal; Cell-Free System; Dermatitis, Contact; Disease Models, Animal; Ganglia, S | 2019 |
Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.
Topics: Animals; Antiviral Agents; Artificial Intelligence; Chlorocebus aethiops; Disease Models, Animal; Dr | 2020 |
Antiviral activity of the marine alga Symphyocladia latiuscula against herpes simplex virus (HSV-1) in vitro and its therapeutic efficacy against HSV-1 infection in mice.
Topics: Acyclovir; Administration, Oral; Animals; Antiviral Agents; Brain; Chlorocebus aethiops; Disease Mod | 2005 |
Interferon prophylaxis against simian varicella in Erythrocebus patas monkeys.
Topics: Animals; Antibodies, Viral; Disease Models, Animal; Erythrocebus patas; Female; Herpes Zoster; Herpe | 1983 |
Effect of acyclovir and phosphonoformate on cytomegalovirus infection in guinea pigs.
Topics: Acyclovir; Animals; Antiviral Agents; Cytomegalovirus Infections; Disease Models, Animal; Foscarnet; | 1984 |
Neurotoxicity of the pyrimidine synthesis inhibitor N-phosphonoacetyl-L-aspartate.
Topics: Adult; Aged; Animals; Antimetabolites, Antineoplastic; Aspartic Acid; Brain Diseases; Disease Models | 1982 |
Intracerebroventricular and intraperitoneal disodium phosphonoacetate treatment of herpes simplex virus type I experimental encephalitis in rats.
Topics: Adult; Animals; Blood-Brain Barrier; Catheterization; Disease Models, Animal; Encephalitis; Herpesvi | 1979 |
Topical phosphonoacetic acid treatment of cutaneous herpes simplex infections in the guinea pig.
Topics: Animals; Croton Oil; Disease Models, Animal; Drug Evaluation, Preclinical; Female; Guinea Pigs; Herp | 1979 |
Comparative evaluation of antiherpetic drugs in animal experiments.
Topics: Animals; Brain Diseases; Disease Models, Animal; Evaluation Studies as Topic; Herpes Simplex; Immuno | 1979 |
Uptake of Tc-99m monophosphate complexes in bone and myocardial necrosis in animals.
Topics: Animals; Bone and Bones; Carbamyl Phosphate; Cardiomyopathies; Disease Models, Animal; Organophospho | 1978 |
Aerosol administration of antiviral agents to treat lung infection due to murine cytomegalovirus.
Topics: Acyclovir; Administration, Oral; Aerosols; Animals; Antiviral Agents; Cytomegalovirus Infections; Di | 1988 |
Limited efficacy of inhibitors of herpes simplex virus DNA synthesis in murine models of recrudescent disease.
Topics: Acyclovir; Administration, Oral; Administration, Topical; Animals; Antiviral Agents; Disease Models, | 1988 |
Herpes simplex virus hepatitis in mice: effects of treatment with trisodium phosphonoformate.
Topics: Animals; Antiviral Agents; Disease Models, Animal; Foscarnet; Hepatitis, Viral, Animal; Herpes Simpl | 1985 |
The effects of topical foscarnet in a new model of herpes simplex skin infection.
Topics: Administration, Cutaneous; Animals; Antiviral Agents; Disease Models, Animal; Foscarnet; Herpes Simp | 1987 |