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phosphonoacetic acid and Cholera Infantum

phosphonoacetic acid has been researched along with Cholera Infantum in 6 studies

Phosphonoacetic Acid: A simple organophosphorus compound that inhibits DNA polymerase, especially in viruses and is used as an antiviral agent.
phosphonoacetic acid : A member of the class of phosphonic acids that is phosphonic acid in which the hydrogen attached to the phosphorous is replaced by a carboxymethyl group.

Research Excerpts

ExcerptRelevanceReference
"Foscarnet was administered as a continuous infusion of 200 mg/kg (prior to 1988) or as an intermittent infusion of 60 mg/kg t."2.67Treatment of HIV-related cytomegalovirus disease of the gastrointestinal tract with foscarnet. ( Blanshard, C, 1992)
"Four of ten patients with colorectal cancer responded to the treatment (four partial responses), of whom three had been treated previously."2.67A phase I, II study of high-dose 5-fluorouracil and high-dose leucovorin with low-dose phosphonacetyl-L-aspartic acid in patients with advanced malignancies. ( Ardalan, B; Benedetto, P; Feun, L; Fodor, M; Livingstone, A; Morrell, L; Richman, S; Savaraj, N; Sridhar, KS; Waldman, S, 1991)
"5-Fluorouracil (FUra) is a clinically useful antineoplastic agent."1.27Phase I and clinical pharmacological evaluation of biochemical modulation of 5-fluorouracil with N-(phosphonacetyl)-L-aspartic acid. ( Casper, ES; Martin, DS; Vale, K; Williams, LJ; Young, CW, 1983)
" Since toxicity is a prominent impediment, the possibility of therapeutic synergy may perhaps be explored at drastically reduced doses of PALA, combined with other modulating measures."1.27Weekly 5-fluorouracil combined with PALA: toxic and therapeutic effects in colorectal cancer. ( Camacho, FJ; Engstrom, PF; Green, MD; Greenwald, ES; Kaplan, BH; Muggia, FM; Wernz, JC, 1987)

Research

Studies (6)

TimeframeStudies, this research(%)All Research%
pre-19904 (66.67)18.7374
1990's2 (33.33)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Casper, ES2
Vale, K1
Williams, LJ1
Martin, DS1
Young, CW2
Gralla, RJ1
Natale, RB1
Yagoda, A1
Blanshard, C1
Ardalan, B1
Sridhar, KS1
Benedetto, P1
Richman, S1
Waldman, S1
Morrell, L1
Feun, L1
Savaraj, N1
Fodor, M1
Livingstone, A1
Muggia, FM1
Camacho, FJ1
Kaplan, BH1
Green, MD1
Greenwald, ES1
Wernz, JC1
Engstrom, PF1
Markman, M1
Chan, TC1
Cleary, S1
Howell, SB1

Trials

2 trials available for phosphonoacetic acid and Cholera Infantum

ArticleYear
Treatment of HIV-related cytomegalovirus disease of the gastrointestinal tract with foscarnet.
    Journal of acquired immune deficiency syndromes, 1992, Volume: 5 Suppl 1

    Topics: Acquired Immunodeficiency Syndrome; Antiviral Agents; Cytomegalovirus Infections; Female; Foscarnet;

1992
A phase I, II study of high-dose 5-fluorouracil and high-dose leucovorin with low-dose phosphonacetyl-L-aspartic acid in patients with advanced malignancies.
    Cancer, 1991, Sep-15, Volume: 68, Issue:6

    Topics: Adult; Aged; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Aspartic Acid; B

1991

Other Studies

4 other studies available for phosphonoacetic acid and Cholera Infantum

ArticleYear
Phase I and clinical pharmacological evaluation of biochemical modulation of 5-fluorouracil with N-(phosphonacetyl)-L-aspartic acid.
    Cancer research, 1983, Volume: 43, Issue:5

    Topics: Adult; Aged; Antimetabolites, Antineoplastic; Aspartic Acid; Blood Cell Count; Carcinoma; Drug Admin

1983
Phase I trial of PALA.
    Cancer treatment reports, 1980, Volume: 64, Issue:12

    Topics: Antineoplastic Agents; Aspartic Acid; Brain Diseases; Diarrhea; Dose-Response Relationship, Drug; Ga

1980
Weekly 5-fluorouracil combined with PALA: toxic and therapeutic effects in colorectal cancer.
    Cancer treatment reports, 1987, Volume: 71, Issue:3

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Aspartic Acid; Central Nervous System D

1987
Phase I trial of combination therapy of cancer with N-phosphonacetyl-L-aspartic acid and dipyridamole.
    Cancer chemotherapy and pharmacology, 1987, Volume: 19, Issue:1

    Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Aspartic Acid; Dipyr

1987