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phosphonoacetic acid and Carcinoma

phosphonoacetic acid has been researched along with Carcinoma in 7 studies

Phosphonoacetic Acid: A simple organophosphorus compound that inhibits DNA polymerase, especially in viruses and is used as an antiviral agent.
phosphonoacetic acid : A member of the class of phosphonic acids that is phosphonic acid in which the hydrogen attached to the phosphorous is replaced by a carboxymethyl group.

Carcinoma: A malignant neoplasm made up of epithelial cells tending to infiltrate the surrounding tissues and give rise to metastases. It is a histological type of neoplasm and not a synonym for cancer.

Research Excerpts

ExcerptRelevanceReference
"Variants of the Lewis lung carcinoma were selected for resistance to N-(phosphonacetyl)-L-aspartic acid (PALA) by treatment of tumor-bearing mice with repetitive subcurative doses of PALA."7.66Mechanism of resistance of variants of the Lewis lung carcinoma to N-(phosphonacetyl)-L-aspartic acid. ( Ardalan, B; Cooney, DA; Cysyk, RL; Han, N; Hankerson, JG; Harley, C; Jayaram, HN; Johnson, RK; Kensler, TW; Mutter, G; Reck, LJ, 1981)
"Variants of the Lewis lung carcinoma were selected for resistance to N-(phosphonacetyl)-L-aspartic acid (PALA) by treatment of tumor-bearing mice with repetitive subcurative doses of PALA."3.66Mechanism of resistance of variants of the Lewis lung carcinoma to N-(phosphonacetyl)-L-aspartic acid. ( Ardalan, B; Cooney, DA; Cysyk, RL; Han, N; Hankerson, JG; Harley, C; Jayaram, HN; Johnson, RK; Kensler, TW; Mutter, G; Reck, LJ, 1981)
"5-Fluorouracil (FUra) is a clinically useful antineoplastic agent."1.27Phase I and clinical pharmacological evaluation of biochemical modulation of 5-fluorouracil with N-(phosphonacetyl)-L-aspartic acid. ( Casper, ES; Martin, DS; Vale, K; Williams, LJ; Young, CW, 1983)
"One of the responding patients with colon cancer and two with breast cancer had failed to respond to prior therapy with 5-FU; one of the responding patients with breast cancer had previously received an inadequate trial of a similar regimen."1.26Phase II trial of combination therapy with continuous-infusion PALA and bolus-injection 5-FU. ( Ervin, TJ; Kufe, DW; Meshad, MW; Weiss, GR, 1982)

Research

Studies (7)

TimeframeStudies, this research(%)All Research%
pre-19907 (100.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Presant, CA1
Ardalan, B2
Multhauf, P1
Chan, C1
Staples, R1
Green, L1
Browning, S1
Carr, BI1
Chang, FF1
Thayer, W1
Casper, ES1
Vale, K1
Williams, LJ1
Martin, DS1
Young, CW1
Weiss, GR1
Ervin, TJ1
Meshad, MW1
Kufe, DW1
Kensler, TW2
Mutter, G1
Hankerson, JG1
Reck, LJ2
Harley, C1
Han, N1
Cysyk, RL1
Johnson, RK2
Jayaram, HN1
Cooney, DA2
Osieka, R1
Houchens, DP1
Goldin, A1
Chiou, JF1
Li, JK1
Cheng, YC1

Other Studies

7 other studies available for phosphonoacetic acid and Carcinoma

ArticleYear
Continuous five-day infusion of PALA and 5FU: a pilot phase II trial.
    Medical and pediatric oncology, 1983, Volume: 11, Issue:3

    Topics: Adult; Aged; Aspartic Acid; Carcinoma; Colonic Neoplasms; Drug Administration Schedule; Drug Eruptio

1983
Phase I and clinical pharmacological evaluation of biochemical modulation of 5-fluorouracil with N-(phosphonacetyl)-L-aspartic acid.
    Cancer research, 1983, Volume: 43, Issue:5

    Topics: Adult; Aged; Antimetabolites, Antineoplastic; Aspartic Acid; Blood Cell Count; Carcinoma; Drug Admin

1983
Phase II trial of combination therapy with continuous-infusion PALA and bolus-injection 5-FU.
    Cancer treatment reports, 1982, Volume: 66, Issue:2

    Topics: Adult; Aged; Aspartic Acid; Breast Neoplasms; Carcinoma; Colonic Neoplasms; Drug Evaluation; Drug Th

1982
Mechanism of resistance of variants of the Lewis lung carcinoma to N-(phosphonacetyl)-L-aspartic acid.
    Cancer research, 1981, Volume: 41, Issue:3

    Topics: Amides; Animals; Aspartate Carbamoyltransferase; Aspartic Acid; Carcinoma; Cell Line; Dose-Response

1981
Therapeutic effects of acivicin and N-(phosphonacetyl)-L-aspartic acid in a biochemically designed trial against a N-(phosphonacetyl)-L-aspartic acid-resistant variant of the Lewis lung carcinoma.
    Cancer research, 1981, Volume: 41, Issue:3

    Topics: Animals; Aspartate Carbamoyltransferase; Aspartic Acid; Carbamoyl-Phosphate Synthase (Glutamine-Hydr

1981
Chemotherapy of human colon cancer xenografts in athymic nude mice.
    Cancer, 1977, Volume: 40, Issue:5 Suppl

    Topics: Acridines; Animals; Antimetabolites, Antineoplastic; Antineoplastic Agents; Aspartic Acid; Carcinoma

1977
Demonstration of a stimulatory protein for virus-specified DNA polymerase in phorbol ester-treated Epstein-Barr virus-carrying cells.
    Proceedings of the National Academy of Sciences of the United States of America, 1985, Volume: 82, Issue:17

    Topics: Carcinoma; Cell Line; DNA-Directed DNA Polymerase; Enzyme Activation; Foscarnet; Herpesvirus 4, Huma

1985