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phosphonoacetic acid and Brain Neoplasms

phosphonoacetic acid has been researched along with Brain Neoplasms in 6 studies

Phosphonoacetic Acid: A simple organophosphorus compound that inhibits DNA polymerase, especially in viruses and is used as an antiviral agent.
phosphonoacetic acid : A member of the class of phosphonic acids that is phosphonic acid in which the hydrogen attached to the phosphorous is replaced by a carboxymethyl group.

Brain Neoplasms: Neoplasms of the intracranial components of the central nervous system, including the cerebral hemispheres, basal ganglia, hypothalamus, thalamus, brain stem, and cerebellum. Brain neoplasms are subdivided into primary (originating from brain tissue) and secondary (i.e., metastatic) forms. Primary neoplasms are subdivided into benign and malignant forms. In general, brain tumors may also be classified by age of onset, histologic type, or presenting location in the brain.

Research Excerpts

ExcerptRelevanceReference
"To evaluate an intracranial polymer implant containing bromodeoxyuridine (BrdUrd) and N-(phosphonacetyl)-L-aspartic acid (PALA) in combination with external beam radiotherapy (EBRT) in the treatment of a rat glioma."3.72Treatment of intracranial rat glioma model with implant of radiosensitizer and biomodulator drug combined with external beam radiotherapy. ( Lehnert, S; Li, Y; Owusu, A, 2004)
"Malignant gliomas are the most common malignant brain tumors and are almost always fatal."1.28Experimental therapy of human glioma by means of a genetically engineered virus mutant. ( Coen, DM; Malick, A; Markert, JM; Martuza, RL; Ruffner, KL, 1991)

Research

Studies (6)

TimeframeStudies, this research(%)All Research%
pre-19902 (33.33)18.7374
1990's1 (16.67)18.2507
2000's1 (16.67)29.6817
2010's2 (33.33)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Wang, J1
Yin, H1
Panandikar, A1
Gandhi, V1
Sen, S1
Muller, FL1
Colla, S1
Aquilanti, E1
Manzo, VE1
Genovese, G1
Lee, J1
Eisenson, D1
Narurkar, R1
Deng, P1
Nezi, L1
Lee, MA1
Hu, B1
Hu, J1
Sahin, E1
Ong, D1
Fletcher-Sananikone, E1
Ho, D1
Kwong, L1
Brennan, C1
Wang, YA1
Chin, L1
DePinho, RA1
Li, Y1
Owusu, A1
Lehnert, S1
Stewart, DJ1
Leavens, M1
Friedman, J1
Benjamin, RS1
Moore, EC1
Bodey, GP1
Valdivieso, M1
Burgess, MA1
Wiseman, C1
Loo, TL1
Martuza, RL1
Malick, A1
Markert, JM1
Ruffner, KL1
Coen, DM1
Madani, S1
Baillon, J1
Fries, J1
Belhadj, O1
Bettaieb, A1
Ben Hamida, M1
Hervé, G1

Other Studies

6 other studies available for phosphonoacetic acid and Brain Neoplasms

ArticleYear
Elevated cyclin A associated kinase activity promotes sensitivity of metastatic human cancer cells to DNA antimetabolite drug.
    International journal of oncology, 2015, Volume: 47, Issue:2

    Topics: Animals; Antimetabolites, Antineoplastic; Apoptosis; Aspartic Acid; Brain Neoplasms; Cell Line, Tumo

2015
Passenger deletions generate therapeutic vulnerabilities in cancer.
    Nature, 2012, Aug-16, Volume: 488, Issue:7411

    Topics: Animals; Antineoplastic Agents; Biomarkers, Tumor; Brain Neoplasms; Cell Line, Tumor; Cell Prolifera

2012
Treatment of intracranial rat glioma model with implant of radiosensitizer and biomodulator drug combined with external beam radiotherapy.
    International journal of radiation oncology, biology, physics, 2004, Feb-01, Volume: 58, Issue:2

    Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Aspartic Acid; Brain Neoplasms; Bromodeoxyu

2004
Penetration of N-(phosphonacetyl)-L-aspartate into human central nervous system and intracerebral tumor.
    Cancer research, 1980, Volume: 40, Issue:9

    Topics: Aspartic Acid; Brain Neoplasms; Drug Administration Schedule; Drug Evaluation; Female; Humans; Infus

1980
Experimental therapy of human glioma by means of a genetically engineered virus mutant.
    Science (New York, N.Y.), 1991, May-10, Volume: 252, Issue:5007

    Topics: Animals; Antiviral Agents; Brain Neoplasms; Cells, Cultured; Dose-Response Relationship, Drug; Fosca

1991
Pyrimidine pathways enzymes in human tumors of brain and associated tissues: potentialities for the therapeutic use of N-(phosphonacetyl-L-aspartate and 1-beta-D-arabinofuranosylcytosine.
    European journal of cancer & clinical oncology, 1987, Volume: 23, Issue:10

    Topics: Aspartate Carbamoyltransferase; Aspartic Acid; Brain; Brain Neoplasms; Cytarabine; Cytidine Deaminas

1987