phosphonoacetic acid has been researched along with Brain Neoplasms in 6 studies
Phosphonoacetic Acid: A simple organophosphorus compound that inhibits DNA polymerase, especially in viruses and is used as an antiviral agent.
phosphonoacetic acid : A member of the class of phosphonic acids that is phosphonic acid in which the hydrogen attached to the phosphorous is replaced by a carboxymethyl group.
Brain Neoplasms: Neoplasms of the intracranial components of the central nervous system, including the cerebral hemispheres, basal ganglia, hypothalamus, thalamus, brain stem, and cerebellum. Brain neoplasms are subdivided into primary (originating from brain tissue) and secondary (i.e., metastatic) forms. Primary neoplasms are subdivided into benign and malignant forms. In general, brain tumors may also be classified by age of onset, histologic type, or presenting location in the brain.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To evaluate an intracranial polymer implant containing bromodeoxyuridine (BrdUrd) and N-(phosphonacetyl)-L-aspartic acid (PALA) in combination with external beam radiotherapy (EBRT) in the treatment of a rat glioma." | 3.72 | Treatment of intracranial rat glioma model with implant of radiosensitizer and biomodulator drug combined with external beam radiotherapy. ( Lehnert, S; Li, Y; Owusu, A, 2004) |
| "Malignant gliomas are the most common malignant brain tumors and are almost always fatal." | 1.28 | Experimental therapy of human glioma by means of a genetically engineered virus mutant. ( Coen, DM; Malick, A; Markert, JM; Martuza, RL; Ruffner, KL, 1991) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (33.33) | 18.7374 |
| 1990's | 1 (16.67) | 18.2507 |
| 2000's | 1 (16.67) | 29.6817 |
| 2010's | 2 (33.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Wang, J | 1 |
| Yin, H | 1 |
| Panandikar, A | 1 |
| Gandhi, V | 1 |
| Sen, S | 1 |
| Muller, FL | 1 |
| Colla, S | 1 |
| Aquilanti, E | 1 |
| Manzo, VE | 1 |
| Genovese, G | 1 |
| Lee, J | 1 |
| Eisenson, D | 1 |
| Narurkar, R | 1 |
| Deng, P | 1 |
| Nezi, L | 1 |
| Lee, MA | 1 |
| Hu, B | 1 |
| Hu, J | 1 |
| Sahin, E | 1 |
| Ong, D | 1 |
| Fletcher-Sananikone, E | 1 |
| Ho, D | 1 |
| Kwong, L | 1 |
| Brennan, C | 1 |
| Wang, YA | 1 |
| Chin, L | 1 |
| DePinho, RA | 1 |
| Li, Y | 1 |
| Owusu, A | 1 |
| Lehnert, S | 1 |
| Stewart, DJ | 1 |
| Leavens, M | 1 |
| Friedman, J | 1 |
| Benjamin, RS | 1 |
| Moore, EC | 1 |
| Bodey, GP | 1 |
| Valdivieso, M | 1 |
| Burgess, MA | 1 |
| Wiseman, C | 1 |
| Loo, TL | 1 |
| Martuza, RL | 1 |
| Malick, A | 1 |
| Markert, JM | 1 |
| Ruffner, KL | 1 |
| Coen, DM | 1 |
| Madani, S | 1 |
| Baillon, J | 1 |
| Fries, J | 1 |
| Belhadj, O | 1 |
| Bettaieb, A | 1 |
| Ben Hamida, M | 1 |
| Hervé, G | 1 |
6 other studies available for phosphonoacetic acid and Brain Neoplasms
| Article | Year |
|---|---|
Elevated cyclin A associated kinase activity promotes sensitivity of metastatic human cancer cells to DNA antimetabolite drug.
Topics: Animals; Antimetabolites, Antineoplastic; Apoptosis; Aspartic Acid; Brain Neoplasms; Cell Line, Tumo | 2015 |
Passenger deletions generate therapeutic vulnerabilities in cancer.
Topics: Animals; Antineoplastic Agents; Biomarkers, Tumor; Brain Neoplasms; Cell Line, Tumor; Cell Prolifera | 2012 |
Treatment of intracranial rat glioma model with implant of radiosensitizer and biomodulator drug combined with external beam radiotherapy.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Aspartic Acid; Brain Neoplasms; Bromodeoxyu | 2004 |
Penetration of N-(phosphonacetyl)-L-aspartate into human central nervous system and intracerebral tumor.
Topics: Aspartic Acid; Brain Neoplasms; Drug Administration Schedule; Drug Evaluation; Female; Humans; Infus | 1980 |
Experimental therapy of human glioma by means of a genetically engineered virus mutant.
Topics: Animals; Antiviral Agents; Brain Neoplasms; Cells, Cultured; Dose-Response Relationship, Drug; Fosca | 1991 |
Pyrimidine pathways enzymes in human tumors of brain and associated tissues: potentialities for the therapeutic use of N-(phosphonacetyl-L-aspartate and 1-beta-D-arabinofuranosylcytosine.
Topics: Aspartate Carbamoyltransferase; Aspartic Acid; Brain; Brain Neoplasms; Cytarabine; Cytidine Deaminas | 1987 |