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phosphonoacetic acid and Abnormalities, Autosome

phosphonoacetic acid has been researched along with Abnormalities, Autosome in 10 studies

Phosphonoacetic Acid: A simple organophosphorus compound that inhibits DNA polymerase, especially in viruses and is used as an antiviral agent.
phosphonoacetic acid : A member of the class of phosphonic acids that is phosphonic acid in which the hydrogen attached to the phosphorous is replaced by a carboxymethyl group.

Research Excerpts

ExcerptRelevanceReference
"In cells with multiple chromosomal aberrations and rearranged copies of chromosome 2, amplification of CAD as tandem arrays from rearranged chromosomes is the most frequent mechanism of PALA resistance."1.30Multiple mechanisms of N-phosphonacetyl-L-aspartate resistance in human cell lines: carbamyl-P synthetase/aspartate transcarbamylase/dihydro-orotase gene amplification is frequent only when chromosome 2 is rearranged. ( Agarwal, A; Agarwal, ML; Chernova, OB; Davidson, JN; Duncan, P; Groves, RP; Martínez, JL; Patterson, TE; Smith, KA; Stark, GR; Stark, MB; Trent, JM, 1997)

Research

Studies (10)

TimeframeStudies, this research(%)All Research%
pre-19902 (20.00)18.7374
1990's6 (60.00)18.2507
2000's2 (20.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Mondello, C1
Guasconi, V1
Giulotto, E1
Nuzzo, F1
Mathew, R1
Kongara, S1
Beaudoin, B1
Karp, CM1
Bray, K1
Degenhardt, K1
Chen, G1
Jin, S1
White, E1
Wahl, GM2
Vitto, L1
Padgett, RA1
Stark, GR2
Di Leonardo, A3
Cavolina, P2
Maddalena, A1
Tlsty, TD2
Jonczyk, P1
White, A1
Sage, M1
Hall, I1
Schaefer, D1
Briot, A1
Livanos, E1
Roelofs, H1
Poulose, B1
Schaefer, DI1
Livanos, EM1
White, AE1
Linke, SP1
Clarkin, KC1
Tsou, A1
Smith, KA1
Chernova, OB1
Groves, RP1
Stark, MB1
Martínez, JL1
Davidson, JN1
Trent, JM1
Patterson, TE1
Agarwal, A1
Duncan, P1
Agarwal, ML1
Soulie, P1
Poupon, MF1
Remvikos, Y1
Dutrillaux, B1
Muleris, M1
Ottaggio, L1
Agnese, C1
Bonatti, S1
De Ambrosis, A1
Degan, P1
Miele, M1
Randazzo, R1
Abbondandolo, A1

Other Studies

10 other studies available for phosphonoacetic acid and Abnormalities, Autosome

ArticleYear
Gamma-ray and hydrogen peroxide induction of gene amplification in hamster cells deficient in DNA double strand break repair.
    DNA repair, 2002, Jun-21, Volume: 1, Issue:6

    Topics: Animals; Antimetabolites, Antineoplastic; Aspartic Acid; Cell Line; Chromosome Aberrations; Cricetin

2002
Autophagy suppresses tumor progression by limiting chromosomal instability.
    Genes & development, 2007, Jun-01, Volume: 21, Issue:11

    Topics: Animals; Apoptosis; Apoptosis Regulatory Proteins; Aspartic Acid; Autophagy; Autophagy-Related Prote

2007
Single-copy and amplified CAD genes in Syrian hamster chromosomes localized by a highly sensitive method for in situ hybridization.
    Molecular and cellular biology, 1982, Volume: 2, Issue:3

    Topics: Animals; Aspartic Acid; Cells, Cultured; Chromosome Aberrations; Chromosome Mapping; Cricetinae; Dex

1982
DNA topoisomerase II inhibition and gene amplification in V79/B7 cells.
    Mutation research, 1993, Volume: 301, Issue:3

    Topics: Animals; Aspartate Carbamoyltransferase; Aspartic Acid; Benzamides; Carbamoyl-Phosphate Synthase (Gl

1993
Loss of chromosomal integrity in neoplasia.
    Cold Spring Harbor symposia on quantitative biology, 1993, Volume: 58

    Topics: Animals; Aspartate Carbamoyltransferase; Aspartic Acid; Carbamoyl-Phosphate Synthase (Glutamine-Hydr

1993
Multiple mechanisms of N-(phosphonoacetyl)-L-aspartate drug resistance in SV40-infected precrisis human fibroblasts.
    Cancer research, 1993, Oct-15, Volume: 53, Issue:20

    Topics: Aneuploidy; Antineoplastic Agents; Aspartic Acid; Cell Cycle; Cell Division; Cell Line; Cell Transfo

1993
A reversible, p53-dependent G0/G1 cell cycle arrest induced by ribonucleotide depletion in the absence of detectable DNA damage.
    Genes & development, 1996, Apr-15, Volume: 10, Issue:8

    Topics: Adenosine Monophosphate; Amides; Antimetabolites, Antineoplastic; Aspartic Acid; Cell Cycle; Cells,

1996
Multiple mechanisms of N-phosphonacetyl-L-aspartate resistance in human cell lines: carbamyl-P synthetase/aspartate transcarbamylase/dihydro-orotase gene amplification is frequent only when chromosome 2 is rearranged.
    Proceedings of the National Academy of Sciences of the United States of America, 1997, Mar-04, Volume: 94, Issue:5

    Topics: Aspartate Carbamoyltransferase; Aspartic Acid; Carbamoyl-Phosphate Synthase (Glutamine-Hydrolyzing);

1997
Distinct chromosomal alterations associated with TP53 status of LoVo cells under PALA selective pressure: a parallel with cytogenetic pathways of colorectal cancers.
    Oncogene, 1999, Jan-21, Volume: 18, Issue:3

    Topics: Aspartic Acid; Chromosome Aberrations; Colorectal Neoplasms; Drug Resistance; Enzyme Inhibitors; Gen

1999
Chromosome aberrations associated with CAD gene amplification in Chinese hamster cultured cells.
    Mutation research, 1988, Volume: 199, Issue:1

    Topics: Animals; Aspartate Carbamoyltransferase; Aspartic Acid; Carbamoyl-Phosphate Synthase (Glutamine-Hydr

1988