phosphoenolpyruvate has been researched along with Neoplasms in 9 studies
Phosphoenolpyruvate: A monocarboxylic acid anion derived from selective deprotonation of the carboxy group of phosphoenolpyruvic acid. It is a metabolic intermediate in GLYCOLYSIS; GLUCONEOGENESIS; and other pathways.
phosphoenolpyruvate : A monocarboxylic acid anion resuting from selective deprotonation of the carboxy group of phosphoenolpyruvic acid.
phosphoenolpyruvic acid : A monocarboxylic acid that is acrylic acid substituted by a phosphonooxy group at position 2. It is a metabolic intermediate in pathways like glycolysis and gluconeogenesis.
Neoplasms: New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Metformin (Met), a first-line drug for type 2 diabetes, lowers blood glucose levels by suppressing gluconeogenesis in the liver, presumably through the liver kinase B1-dependent activation of AMP-activated protein kinase (AMPK) after inhibiting respiratory chain complex I." | 1.72 | Nutrient Condition in the Microenvironment Determines Essential Metabolisms of CD8 ( Chao, R; Kudo, I; Nishida, M; Tokumasu, M; Udono, H; Yamashita, N; Zhao, W, 2022) |
| "It is thought that cancer cells engage in Warburg metabolism to meet intrinsic biosynthetic requirements of cell growth and proliferation." | 1.42 | Nutrient Competition: A New Axis of Tumor Immunosuppression. ( Restifo, NP; Roychoudhuri, R; Sukumar, M, 2015) |
| "Our results define a role for PCK2 in cancer cell metabolic reprogramming that promotes glucose-independent cell growth and metabolic stress resistance in human tumors." | 1.42 | Mitochondrial Phosphoenolpyruvate Carboxykinase Regulates Metabolic Adaptation and Enables Glucose-Independent Tumor Growth. ( Artyomov, MN; Avizonis, D; Blagih, J; Bridon, G; Choinière, L; Coelho, PP; Elder, DJ; Flynn, BR; Gingras, MC; Griss, T; Jones, RG; Loginicheva, E; Ntimbane, T; Pause, A; Raissi, TC; Samborska, B; Sergushichev, A; Tavaré, JM; Thomas, EC; Vincent, EE, 2015) |
| "Many cancer cells have increased rates of aerobic glycolysis, a phenomenon termed the Warburg effect." | 1.39 | M2 isoform of pyruvate kinase is dispensable for tumor maintenance and growth. ( Chene, P; Cortés-Cros, M; Ferretti, S; Gounarides, JS; Haberkorn, A; Hemmerlin, C; Hofmann, F; Muller, A; Sellers, WR; Yin, H; Zhang, J, 2013) |
| "Proliferating cells, including cancer cells, require altered metabolism to efficiently incorporate nutrients such as glucose into biomass." | 1.36 | Evidence for an alternative glycolytic pathway in rapidly proliferating cells. ( Amador-Noguez, D; Asara, JM; Cantley, LC; Christofk, HR; Heffron, GJ; Locasale, JW; Rabinowitz, JD; Sharfi, H; Swanson, KD; Vander Heiden, MG; Wagner, G, 2010) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (11.11) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 7 (77.78) | 24.3611 |
| 2020's | 1 (11.11) | 2.80 |
| Authors | Studies |
|---|---|
| Chao, R | 1 |
| Nishida, M | 1 |
| Yamashita, N | 1 |
| Tokumasu, M | 1 |
| Zhao, W | 1 |
| Kudo, I | 1 |
| Udono, H | 1 |
| Kumar, B | 1 |
| Bamezai, RN | 1 |
| Sukumar, M | 1 |
| Roychoudhuri, R | 1 |
| Restifo, NP | 1 |
| Vincent, EE | 1 |
| Sergushichev, A | 1 |
| Griss, T | 1 |
| Gingras, MC | 1 |
| Samborska, B | 1 |
| Ntimbane, T | 1 |
| Coelho, PP | 1 |
| Blagih, J | 1 |
| Raissi, TC | 1 |
| Choinière, L | 1 |
| Bridon, G | 1 |
| Loginicheva, E | 1 |
| Flynn, BR | 1 |
| Thomas, EC | 1 |
| Tavaré, JM | 1 |
| Avizonis, D | 1 |
| Pause, A | 1 |
| Elder, DJ | 1 |
| Artyomov, MN | 1 |
| Jones, RG | 1 |
| Vander Heiden, MG | 2 |
| Locasale, JW | 2 |
| Swanson, KD | 1 |
| Sharfi, H | 1 |
| Heffron, GJ | 1 |
| Amador-Noguez, D | 1 |
| Christofk, HR | 1 |
| Wagner, G | 1 |
| Rabinowitz, JD | 1 |
| Asara, JM | 1 |
| Cantley, LC | 2 |
| Najafov, A | 1 |
| Alessi, DR | 1 |
| Cortés-Cros, M | 1 |
| Hemmerlin, C | 1 |
| Ferretti, S | 1 |
| Zhang, J | 1 |
| Gounarides, JS | 1 |
| Yin, H | 1 |
| Muller, A | 1 |
| Haberkorn, A | 1 |
| Chene, P | 1 |
| Sellers, WR | 1 |
| Hofmann, F | 1 |
| Gosalvez, M | 1 |
| Pérez-García, J | 1 |
| Weinhouse, S | 1 |
9 other studies available for phosphoenolpyruvate and Neoplasms
| Article | Year |
|---|---|
Nutrient Condition in the Microenvironment Determines Essential Metabolisms of CD8
Topics: AMP-Activated Protein Kinases; Animals; CD8-Positive T-Lymphocytes; Diabetes Mellitus, Type 2; Gluco | 2022 |
Moderate DNA damage promotes metabolic flux into PPP via PKM2 Y-105 phosphorylation: a feature that favours cancer cells.
Topics: Carrier Proteins; DNA Damage; DNA, Neoplasm; Gene Expression Regulation; HeLa Cells; Humans; Membran | 2015 |
Nutrient Competition: A New Axis of Tumor Immunosuppression.
Topics: Animals; CD4-Positive T-Lymphocytes; CD8-Positive T-Lymphocytes; Glycolysis; Lymphocytes, Tumor-Infi | 2015 |
Mitochondrial Phosphoenolpyruvate Carboxykinase Regulates Metabolic Adaptation and Enables Glucose-Independent Tumor Growth.
Topics: Adaptation, Physiological; Animals; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell Prolifera | 2015 |
Evidence for an alternative glycolytic pathway in rapidly proliferating cells.
Topics: Adenosine Triphosphate; Animals; Cell Line; Cell Line, Tumor; Cell Proliferation; Female; Glucose; G | 2010 |
Uncoupling the Warburg effect from cancer.
Topics: Genetic Variation; Glycolysis; Humans; Metabolic Networks and Pathways; Neoplasms; Phosphoenolpyruva | 2010 |
Rewiring of glycolysis in cancer cell metabolism.
Topics: Adenosine Triphosphate; Citric Acid Cycle; Energy Metabolism; Glycolysis; Humans; Neoplasms; Phospho | 2010 |
M2 isoform of pyruvate kinase is dispensable for tumor maintenance and growth.
Topics: Carbon Isotopes; Cell Line, Tumor; Chromatography, Ion Exchange; DNA Primers; Gene Knockdown Techniq | 2013 |
Competition for ADP between pyruvate kinase and mitochondrial oxidative phosphorylation as a control mechanism in glycolysis.
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Animals; Glucose; Glucosephosphates; Glutamates; Glyc | 1974 |