phosphoenolpyruvate has been researched along with Diabetes Mellitus, Type 2 in 9 studies
Phosphoenolpyruvate: A monocarboxylic acid anion derived from selective deprotonation of the carboxy group of phosphoenolpyruvic acid. It is a metabolic intermediate in GLYCOLYSIS; GLUCONEOGENESIS; and other pathways.
phosphoenolpyruvate : A monocarboxylic acid anion resuting from selective deprotonation of the carboxy group of phosphoenolpyruvic acid.
phosphoenolpyruvic acid : A monocarboxylic acid that is acrylic acid substituted by a phosphonooxy group at position 2. It is a metabolic intermediate in pathways like glycolysis and gluconeogenesis.
Diabetes Mellitus, Type 2: A subclass of DIABETES MELLITUS that is not INSULIN-responsive or dependent (NIDDM). It is characterized initially by INSULIN RESISTANCE and HYPERINSULINEMIA; and eventually by GLUCOSE INTOLERANCE; HYPERGLYCEMIA; and overt diabetes. Type II diabetes mellitus is no longer considered a disease exclusively found in adults. Patients seldom develop KETOSIS but often exhibit OBESITY.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Gluconeogenesis increases in diabetic nephropathy (DN), escalating fasting and postprandial glucose levels." | 1.91 | PCK1 Protects against Mitoribosomal Defects in Diabetic Nephropathy in Mouse Models. ( Hasegawa, K; Sakamaki, Y; Tamaki, M; Wakino, S, 2023) |
| "Furthermore, people with type 2 diabetes display elevated hepatic neddylation levels." | 1.91 | Neddylation of phosphoenolpyruvate carboxykinase 1 controls glucose metabolism. ( Bravo, SB; Chantada-Vazquez, P; Coppari, R; da Silva Lima, N; Delgado, TC; Diaz-Moreno, I; Diaz-Quintana, A; Dieguez, C; Fernández, U; Fondevila, MF; Frühbeck, G; Gonzalez-Rellan, MJ; Guallar, D; Lopez, M; Martinez-Chantar, ML; Nogueiras, R; Novoa, E; Parracho, T; Perez-Mejias, G; Prevot, V; Ramos, L; Riobello, C; Rodríguez, A; Schwaninger, M; Serrano-Maciá, M; Tovar, S; Veyrat-Durebex, C; Woodhoo, A, 2023) |
| "Metformin (Met), a first-line drug for type 2 diabetes, lowers blood glucose levels by suppressing gluconeogenesis in the liver, presumably through the liver kinase B1-dependent activation of AMP-activated protein kinase (AMPK) after inhibiting respiratory chain complex I." | 1.72 | Nutrient Condition in the Microenvironment Determines Essential Metabolisms of CD8 ( Chao, R; Kudo, I; Nishida, M; Tokumasu, M; Udono, H; Yamashita, N; Zhao, W, 2022) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (11.11) | 18.2507 |
| 2000's | 1 (11.11) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 7 (77.78) | 2.80 |
| Authors | Studies |
|---|---|
| Saleh, SR | 1 |
| Zaki, R | 1 |
| Hassan, R | 1 |
| El-Kersh, MA | 1 |
| El-Sayed, MM | 1 |
| Abd Elmoneam, AA | 1 |
| Chao, R | 1 |
| Nishida, M | 1 |
| Yamashita, N | 1 |
| Tokumasu, M | 1 |
| Zhao, W | 1 |
| Kudo, I | 1 |
| Udono, H | 1 |
| Hao, J | 1 |
| Zhang, Y | 2 |
| Wu, T | 1 |
| Liu, R | 1 |
| Sui, W | 1 |
| Zhu, J | 1 |
| Fang, S | 1 |
| Geng, J | 1 |
| Zhang, M | 1 |
| Wang, Y | 1 |
| Zhou, F | 1 |
| Li, M | 1 |
| Li, N | 1 |
| Shao, L | 1 |
| López-Soldado, I | 1 |
| Guinovart, JJ | 1 |
| Duran, J | 1 |
| Hasegawa, K | 1 |
| Sakamaki, Y | 1 |
| Tamaki, M | 1 |
| Wakino, S | 1 |
| Gonzalez-Rellan, MJ | 1 |
| Fernández, U | 1 |
| Parracho, T | 1 |
| Novoa, E | 1 |
| Fondevila, MF | 1 |
| da Silva Lima, N | 1 |
| Ramos, L | 1 |
| Rodríguez, A | 1 |
| Serrano-Maciá, M | 1 |
| Perez-Mejias, G | 1 |
| Chantada-Vazquez, P | 1 |
| Riobello, C | 1 |
| Veyrat-Durebex, C | 1 |
| Tovar, S | 1 |
| Coppari, R | 1 |
| Woodhoo, A | 1 |
| Schwaninger, M | 1 |
| Prevot, V | 1 |
| Delgado, TC | 1 |
| Lopez, M | 1 |
| Diaz-Quintana, A | 1 |
| Dieguez, C | 1 |
| Guallar, D | 1 |
| Frühbeck, G | 1 |
| Diaz-Moreno, I | 1 |
| Bravo, SB | 1 |
| Martinez-Chantar, ML | 1 |
| Nogueiras, R | 1 |
| Jin, ES | 1 |
| Burgess, SC | 1 |
| Merritt, ME | 1 |
| Sherry, AD | 1 |
| Malloy, CR | 1 |
| Diraison, F | 1 |
| Large, V | 1 |
| Brunengraber, H | 1 |
| Beylot, M | 1 |
1 trial available for phosphoenolpyruvate and Diabetes Mellitus, Type 2
| Article | Year |
|---|---|
Non-invasive tracing of liver intermediary metabolism in normal subjects and in moderately hyperglycaemic NIDDM subjects. Evidence against increased gluconeogenesis and hepatic fatty acid oxidation in NIDDM.
Topics: Adult; Alanine; Blood Glucose; Carbon Isotopes; Citric Acid; Citric Acid Cycle; Diabetes Mellitus, T | 1998 |
8 other studies available for phosphoenolpyruvate and Diabetes Mellitus, Type 2
| Article | Year |
|---|---|
The impact of vitamin A supplementation on thyroid function and insulin sensitivity: implication of deiodinases and phosphoenolpyruvate carboxykinase in male Wistar rats.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Type 2; Dietary Supplements; Glucose; Hypothyroidism; Ins | 2022 |
Nutrient Condition in the Microenvironment Determines Essential Metabolisms of CD8
Topics: AMP-Activated Protein Kinases; Animals; CD8-Positive T-Lymphocytes; Diabetes Mellitus, Type 2; Gluco | 2022 |
The antidiabetic effects of
Topics: Animals; Bifidobacterium; Blood Glucose; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; | 2022 |
MiR-34a-5p promotes hepatic gluconeogenesis by suppressing SIRT1 expression.
Topics: Animals; Diabetes Mellitus, Type 2; Gluconeogenesis; Glucose; Liver; Mice; MicroRNAs; Phosphoenolpyr | 2022 |
Hepatic overexpression of protein targeting to glycogen attenuates obesity and improves hyperglycemia in db/db mice.
Topics: Adenosine Triphosphate; Animals; Diabetes Mellitus, Type 2; Glucose; Hyperglycemia; Lipids; Liver; L | 2022 |
PCK1 Protects against Mitoribosomal Defects in Diabetic Nephropathy in Mouse Models.
Topics: Albuminuria; Animals; Collagen Type IV; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; | 2023 |
Neddylation of phosphoenolpyruvate carboxykinase 1 controls glucose metabolism.
Topics: Animals; Diabetes Mellitus, Type 2; Glucose; Liver; Lysine; Mice; Phosphoenolpyruvate; Proteins | 2023 |
Differing mechanisms of hepatic glucose overproduction in triiodothyronine-treated rats vs. Zucker diabetic fatty rats by NMR analysis of plasma glucose.
Topics: Animals; Blood Glucose; Citric Acid Cycle; Diabetes Mellitus, Type 2; Glucose; Glycerol; Glycogen; K | 2005 |