phosphocreatinine and Ventricular-Fibrillation

The association between phosphocreatine's antifibrillatory action and its effect on the excitement propagation processes in the ischemic area was investigated under acute coronary arterial occlusion in dogs. Ischemia considerably reduced the amplitude, and increased the duration and time of onset, in local electrograms, and provoked cardiac fibrillation at the time of occlusion or during the recovery of coronary flow. A single intravenous injection of 300 mg/kg phosphocreatine eliminated cardiac fibrillation and largely prevented electrographic changes in the ischemized area. Phosphocreatinine, phosphocreatine's structural analogue, produced a similar effect. It is suggested that antiarrhythmic action of phosphocreatine and phosphocreatinine is mediated by their membrane effects.

Topics: Acute Disease; Animals; Anti-Arrhythmia Agents; Coronary Disease; Dogs; Drug Evaluation, Preclinical; Heart Conduction System; Kinetics; Phosphocreatine; Ventricular Fibrillation

The mechanism of antiarrhythmic action of phosphocreatine on ischemic myocardium was studied by analyses of electrograms from normal and ischemic tissues. Ischemia induced significant changes in amplitude, duration, and conduction time of the electrograms, thereby showing depolarization of membranes and retarded conduction of excitation. Phosphocreatine administered in a single dose, 300 mg/kg iv, completely eliminated ventricular fibrillations in the ischemic hearts and significantly diminished the electrical instability occurring during reperfusion. The effects of phosphocreatine were completely reproduced by its structural analog phosphocreatine which is inactive in the creatine kinase reaction. It is concluded that the antiarrhythmic effect of both compounds is related to their specific chemical structure and that their specific effect is likely to be mediated via interaction with a sarcolemma site.

Topics: Animals; Anti-Arrhythmia Agents; Coronary Disease; Dogs; Electrocardiography; Phosphocreatine; Ventricular Fibrillation

Topics: Animals; Arrhythmias, Cardiac; Cats; Coronary Vessels; Disease Models, Animal; Heart Ventricles; Ligation; Myocardial Infarction; Phosphocreatine; Sympathetic Nervous System; Ventricular Fibrillation