phosphocreatine and Tetralogy-of-Fallot

During surgical correction of Fallot's tetrad the authors discovered the decrease of macroergic phosphate concentration and moderately marked signs of cardiomyocytic ultrastructural changes, such as mitochondrial injuries, decrease of glycogen levels, insignificant intracellular edema, no increase of membrane penetration. Changes of endothelial cells were absent. In children not over 1 year old under myocardial protection with hypothermic perfusion (at low volume rates) some decrease of macroergic phosphates occurred, as well as a moderate decrease of the mitochondrial index, glycogen content decrease, there was no intracellular edema. The discovered structural changes are minimal and reversible. A close correlation was found between the electron microscopic data and the character of myocardial energetic metabolism, the biochemical changes preceding the ultrastructural ones. Comparison of morpho- and biochemical changes in the myocardium of the majority of patients with impaired myocardial function confirmed the existence of a complex relationship between them.

Topics: Adenosine Triphosphate; Child; Child, Preschool; Endocardial Cushion Defects; Heart Defects, Congenital; Heart Septal Defects, Ventricular; Humans; Myocardium; Phosphocreatine; Tetralogy of Fallot

Topics: Adenosine Triphosphate; Adult; Biopsy; Carbon Dioxide; Glucose; Glucosephosphates; Heart Rate; Hemoglobins; Humans; Hydrogen-Ion Concentration; Lactates; Male; Muscles; Oxygen; Oxygen Consumption; Phosphocreatine; Physical Exertion; Tetralogy of Fallot

Topics: Adenosine Triphosphate; Animals; Dogs; Glucosephosphate Dehydrogenase; Glyceraldehyde-3-Phosphate Dehydrogenases; Heart Arrest, Induced; Humans; Hypothermia, Induced; In Vitro Techniques; Myocardium; Phosphocreatine; Phosphoglycerate Kinase; Tetralogy of Fallot; Time Factors