phosphocreatine and Postpoliomyelitis-Syndrome

phosphocreatine has been researched along with Postpoliomyelitis-Syndrome* in 4 studies

Other Studies

4 other study(ies) available for phosphocreatine and Postpoliomyelitis-Syndrome

ArticleYear
31P MRS evaluation of fatigue in anterior tibial muscle in postpoliomyelitis patients and healthy volunteers.
    Clinical physiology and functional imaging, 2003, Volume: 23, Issue:4

    Changes in concentration of high energy phosphates and pH were studied during rest, exercise and subsequent recovery in the anterior tibial muscle of 10 patients with late effects of poliomyelitis and 10 age- and sex-matched healthy volunteers using 31P MRS. The exercise was dynamic and isometric, and the force levels were individually adapted to each subject and stepwise increased. In general, there were no differences in metabolite changes between the groups, except for lower Pi and Pi/PCr for the volunteers during the recovery phase, also reflected by shorter recovery half-time for Pi. The interindividual variation was much higher for the patient group. Some of the patients showed deviating results probably because of differences in muscle fibre type.

    Topics: Adenosine Triphosphate; Adult; Female; Humans; Hydrogen-Ion Concentration; Magnetic Resonance Spectroscopy; Male; Middle Aged; Muscle Fatigue; Muscle, Skeletal; Phosphocreatine; Phosphorus Isotopes; Physical Exertion; Postpoliomyelitis Syndrome; Tibia

2003
Effects of oral supplementation of coenzyme Q10 on 31P-NMR detected skeletal muscle energy metabolism in middle-aged post-polio subjects and normal volunteers.
    Molecular aspects of medicine, 1997, Volume: 18 Suppl

    The effects of oral supplementation of 100 mg coenzyme Q10 (CoQ10) for 6 months on muscle energy metabolism during exercise and recovery were evaluated in middle-aged post-polio (n = 3) and healthy subjects (n = 4) by the use of phosphorus-31 nuclear magnetic resonance spectroscopy. The metabolic response to isometric plantar flexion at 60% of maximal voluntary contraction force (MVC) for 1.5 min was determined in gastrocnemius muscles before, after 3- (3MO) and 6-month (6MO) of CoQ10 supplementation. The MVC of plantar flexion was unchanged following CoQ10 supplementation. The resting Pi/PCr ratio in gastrocnemius muscles of all subjects decreased after 3MO- and 6MO-CoQ10 (P < 0.05). The post-polio individuals showed a progressive decrease in this ratio, while less pronounced changes were observed in the control subjects. Similarly, the post-polio individuals showed a lower Pi/PCr ratio at the end of 60% MVC in both 3MO- and 6MO-CoQ10, whereas no change in the ratio was observed in the control subjects. A less pronounced decrease in muscle pH was observed at the end of 60% MVC in both 3MO- and 6MO-CoQ10 in the post-polio individuals, but not in the control subjects. No systematic difference in end-exercise ATP was observed between the three phases in both groups. The half-time of recovery for PCr decreased in all subjects after 6MO-CoQ10 supplementation (P < 0.05). The results suggest that CoQ10 supplementation affects muscle energy metabolism in post-polio individuals to a greater extent than in control subjects. The mechanism for this effect is not clear, but may involve an effect of CoQ10 on peripheral circulation in the calf muscles, its action in mitochondrial oxidative phosphorylation and/or its antioxidant potential.

    Topics: Administration, Oral; Adult; Antioxidants; Coenzymes; Endothelium; Energy Metabolism; Female; Humans; Hydrogen-Ion Concentration; Isometric Contraction; Magnetic Resonance Spectroscopy; Male; Middle Aged; Muscle, Skeletal; Oxidative Phosphorylation; Phosphocreatine; Phosphorus Isotopes; Physical Exertion; Postpoliomyelitis Syndrome; Rest; Ubiquinone

1997
Study of fatigue in muscles of patients with post-polio syndrome by in vivo [31P]magnetic resonance spectroscopy. A metabolic cause for fatigue.
    Annals of the New York Academy of Sciences, 1995, May-25, Volume: 753

    Topics: Biopsy; Energy Metabolism; Fatigue; Humans; Hydrogen-Ion Concentration; Magnetic Resonance Spectroscopy; Middle Aged; Muscles; Phosphates; Phosphocreatine; Postpoliomyelitis Syndrome

1995
Excessive muscular fatigue in the postpoliomyelitis syndrome.
    Neurology, 1994, Volume: 44, Issue:4

    To investigate anterior tibial muscle fatigability and metabolism in postpoliomyelitis syndrome patients and controls, we performed measurements of force and relaxation time, as well as 31P magnetic resonance spectroscopy, during intermittent, low-intensity, isometric, voluntary exercise. Both maximum voluntary contraction and tetanic force declined significantly more during exercise and subsequently recovered less in patients compared with controls, indicating greater fatigue in patients. However, intracellular pH and phosphocreatine were not different in the two groups at rest or during exercise or recovery, suggesting that the greater fatigue of the patients was not due to an excessive change of metabolites. Moreover, the pre-exercise half-relaxation time of the tetanus was significantly prolonged in patients compared with controls, and the decline in tetanic force during exercise was linearly related to the half-relaxation time of tetanus, suggesting impaired calcium kinetics. Taken together, the findings of increased fatigability, delayed recovery, and prolonged half-relaxation time, without differences in metabolites, suggest that the fatigue in postpoliomyelitis syndrome may be due to impaired activation beyond the muscle membrane.

    Topics: Action Potentials; Aged; Female; Humans; Isometric Contraction; Male; Middle Aged; Muscle Contraction; Muscles; Muscular Diseases; Phosphocreatine; Physical Exertion; Postpoliomyelitis Syndrome

1994
chemdatabank.com