phosphocreatine and Leukodystrophy--Metachromatic

phosphocreatine has been researched along with Leukodystrophy--Metachromatic* in 1 studies

Other Studies

1 other study(ies) available for phosphocreatine and Leukodystrophy--Metachromatic

Article	Year
Alterations of brain metabolites in metachromatic leukodystrophy as detected by localized proton magnetic resonance spectroscopy in vivo. Journal of neurology, 1993, Volume: 241, Issue:2 The brain morphology and chemistry of seven children with late infantile (4/7) and juvenile (3/7) forms of metachromatic leukodystrophy (MLD) were investigated by magnetic resonance imaging (MRI) and localized proton magnetic resonance spectroscopy (MRS). Patients who were examined at least 6 months after the onset of symptoms (6/7) had severe leukodystrophic changes on MRI. Proton MRS revealed a marked reduction of the neuronal marker N-acetylaspartate in white and grey matter and elevated lactate in demyelinated areas. In contrast to other leukodystrophies MLD patients showed a generalized increase of brain myo-inositol (2- to 3-fold in white matter), indicating a specific role in the pathophysiology of demyelination in MLD. Topics: Adolescent; Aspartic Acid; Bone Marrow Transplantation; Brain; Brain Chemistry; Child; Child, Preschool; Choline; Creatine; Female; Glutamates; Glutamic Acid; Humans; Inositol; Lactates; Lactic Acid; Leukodystrophy, Metachromatic; Magnetic Resonance Imaging; Male; Phosphocreatine; Postoperative Period	1993

Article

Year

Alterations of brain metabolites in metachromatic leukodystrophy as detected by localized proton magnetic resonance spectroscopy in vivo.

Journal of neurology, 1993, Volume: 241, Issue:2

The brain morphology and chemistry of seven children with late infantile (4/7) and juvenile (3/7) forms of metachromatic leukodystrophy (MLD) were investigated by magnetic resonance imaging (MRI) and localized proton magnetic resonance spectroscopy (MRS). Patients who were examined at least 6 months after the onset of symptoms (6/7) had severe leukodystrophic changes on MRI. Proton MRS revealed a marked reduction of the neuronal marker N-acetylaspartate in white and grey matter and elevated lactate in demyelinated areas. In contrast to other leukodystrophies MLD patients showed a generalized increase of brain myo-inositol (2- to 3-fold in white matter), indicating a specific role in the pathophysiology of demyelination in MLD.

Topics: Adolescent; Aspartic Acid; Bone Marrow Transplantation; Brain; Brain Chemistry; Child; Child, Preschool; Choline; Creatine; Female; Glutamates; Glutamic Acid; Humans; Inositol; Lactates; Lactic Acid; Leukodystrophy, Metachromatic; Magnetic Resonance Imaging; Male; Phosphocreatine; Postoperative Period

1993