phosphocreatine and Klinefelter-Syndrome

Klinefelter syndrome (XXY) occurs in 1 in 600 males, resulting in testosterone deficiency and a high prevalence of insulin resistance. Testosterone deficiency in men is a known cause of insulin resistance, and mitochondrial dysfunction is hypothesized to mediate this relationship. The aim of this cross-sectional study was to evaluate muscle mitochondrial function in XXY compared with male controls. Twenty-seven boys with XXY (age 14.7±1.8 years) were compared with 87 controls (age 16.9±0.9). In-vivo calf muscle mitochondrial function was assessed via phosphorus magnetic resonance spectroscopy (

Topics: Adenosine Diphosphate; Adenosine Triphosphate; Adolescent; Case-Control Studies; Child; Cross-Sectional Studies; Humans; Insulin Resistance; Klinefelter Syndrome; Magnetic Resonance Spectroscopy; Male; Mitochondria; Mitochondria, Muscle; Muscle, Skeletal; Phosphocreatine; Testosterone