phosphocreatine and Intestinal-Obstruction

In dogs, a segment of an aborrally occluded small intestine was anastomosed to the right colic flexure; thus, distal to the trapping ileocecal valve a local intestinal obstruction developed within a week in the small and large intestines, which locally stimulates the ileus situtation in man. Distrubances of the energy metabolism, as demonstrated by significant changes in the adenylic acid and phosphocreatine system, were more intensive in the mucosal layers of the small intestine than in those of the large intestine, whereas the smooth muscle layers were unaffected. The results reflect different disturbances of blood flow, energy needs, and adaptability of intestinal mucosa and musculature.

Topics: Adenine Nucleotides; Animals; Colon; Creatine; Dogs; Energy Metabolism; Glucagon; Glycogen; Intestinal Mucosa; Intestinal Obstruction; Intestine, Small; Muscle, Smooth; Phosphocreatine