phosphocreatine and Infant--Premature--Diseases

phosphocreatine has been researched along with Infant--Premature--Diseases* in 2 studies

Other Studies

2 other study(ies) available for phosphocreatine and Infant--Premature--Diseases

Article	Year
Relation between cerebral oxidative metabolism following birth asphyxia, and neurodevelopmental outcome and brain growth at one year. Developmental medicine and child neurology, 1992, Volume: 34, Issue:4 Studies of cerebral oxidative metabolism were carried out by phosphorous magnetic resonance spectroscopy during the first week of life in 52 infants with clinical and/or biochemical evidence of birth asphyxia. 15 infants died and the 37 survivors were assessed by a wide range of neurodevelopmental tests at one year of age. The minimum recorded values for cerebral phosphocreatine/inorganic phosphate concentration ratio (an index of oxidative metabolism) were related to outcome. The results showed a significant relation between the extent of derangement of oxidative metabolism and the severity of adverse outcomes, including death, neurodevelopmental impairment and reduced head growth. Topics: Adenosine Triphosphate; Asphyxia Neonatorum; Birth Weight; Brain; Brain Damage, Chronic; Energy Metabolism; Female; Follow-Up Studies; Gestational Age; Humans; Infant, Newborn; Infant, Premature, Diseases; Magnetic Resonance Imaging; Male; Neurologic Examination; Phosphates; Phosphocreatine	1992
Impaired energy metabolism in brains of newborn infants with increased cerebral echodensities. Lancet (London, England), 1986, May-31, Volume: 1, Issue:8492 Intracellular energy metabolism was studied by phosphorus magnetic resonance spectroscopy in the brains of 27 preterm and term infants with increased echodensities consistent with hypoxic-ischaemic injury and 18 comparable normal infants. In the normal infants the phosphocreatine (PCr)/inorganic orthophosphate (Pi) ratio increased significantly from 0.77 +/- 0.24 (95% confidence limits) at a gestational plus postnatal age of 28 weeks to 1.09 +/- 0.24 at 42 weeks. 9 of the 15 infants with increased echodensities whose PCr/Pi ratios fell below the normal range died; in all 6 survivors cerebral atrophy developed (cysts in brain tissue or microcephaly). In contrast, all 12 infants with increased echodensities whose PCr/Pi ratios remained within the normal range survived, although cerebral atrophy developed in 3 with ratios towards the lower limit of normal. Topics: Age Factors; Brain; Brain Ischemia; Cerebral Hemorrhage; Energy Metabolism; Female; Follow-Up Studies; Humans; Infant, Newborn; Infant, Premature, Diseases; Magnetic Resonance Spectroscopy; Male; Phosphates; Phosphocreatine; Ultrasonography	1986

Article

Year

Relation between cerebral oxidative metabolism following birth asphyxia, and neurodevelopmental outcome and brain growth at one year.

Developmental medicine and child neurology, 1992, Volume: 34, Issue:4

Studies of cerebral oxidative metabolism were carried out by phosphorous magnetic resonance spectroscopy during the first week of life in 52 infants with clinical and/or biochemical evidence of birth asphyxia. 15 infants died and the 37 survivors were assessed by a wide range of neurodevelopmental tests at one year of age. The minimum recorded values for cerebral phosphocreatine/inorganic phosphate concentration ratio (an index of oxidative metabolism) were related to outcome. The results showed a significant relation between the extent of derangement of oxidative metabolism and the severity of adverse outcomes, including death, neurodevelopmental impairment and reduced head growth.

Topics: Adenosine Triphosphate; Asphyxia Neonatorum; Birth Weight; Brain; Brain Damage, Chronic; Energy Metabolism; Female; Follow-Up Studies; Gestational Age; Humans; Infant, Newborn; Infant, Premature, Diseases; Magnetic Resonance Imaging; Male; Neurologic Examination; Phosphates; Phosphocreatine

1992

Impaired energy metabolism in brains of newborn infants with increased cerebral echodensities.

Lancet (London, England), 1986, May-31, Volume: 1, Issue:8492

Intracellular energy metabolism was studied by phosphorus magnetic resonance spectroscopy in the brains of 27 preterm and term infants with increased echodensities consistent with hypoxic-ischaemic injury and 18 comparable normal infants. In the normal infants the phosphocreatine (PCr)/inorganic orthophosphate (Pi) ratio increased significantly from 0.77 +/- 0.24 (95% confidence limits) at a gestational plus postnatal age of 28 weeks to 1.09 +/- 0.24 at 42 weeks. 9 of the 15 infants with increased echodensities whose PCr/Pi ratios fell below the normal range died; in all 6 survivors cerebral atrophy developed (cysts in brain tissue or microcephaly). In contrast, all 12 infants with increased echodensities whose PCr/Pi ratios remained within the normal range survived, although cerebral atrophy developed in 3 with ratios towards the lower limit of normal.

Topics: Age Factors; Brain; Brain Ischemia; Cerebral Hemorrhage; Energy Metabolism; Female; Follow-Up Studies; Humans; Infant, Newborn; Infant, Premature, Diseases; Magnetic Resonance Spectroscopy; Male; Phosphates; Phosphocreatine; Ultrasonography

1986