phosphocreatine and Giant-Cell-Tumors

To study the characteristic changes of 31P-MR spectroscopy of bone and soft tissue tumors.. 41 patients were examined by phosphorus surface coil of 3 tesla MR machine, including 18 benign tumor foci and 28 malignant foci, and adjacent normal muscles. The areas under the peaks of various metabolites in the spectra were measured, including phosphomonoester (PME), inorganic phosphours (Pi), phosphodiester (PDE), phosphocreatine (Pcr), adenosine triphosphate (ATP) gamma, alpha, beta. The ratios of the metabolites to beta-ATP, NTP and Pcr were calculated. Intracellular pH was calculated according to the chemical shift change of Pi relative to Pcr.. The ratios of Pcr/PME and PME/NTP in benign and malignant tumor groups were significantly different from those of the normal group (P<0.05). Between benign and malignant tumor groups, the ratios of PME/beta-ATP and PME/NTP were significantly different (P<0.05).. Pcr/PME and PME/NTP are potential diagnostic indexes of bone and soft tissue tumors. PME/beta-ATP and PME/NTP are potential indexes of differential diagnosis of bone and soft tissue tumors.

Topics: Adenosine Triphosphate; Adolescent; Adult; Aged; Bone Neoplasms; Child; Diagnosis, Differential; Female; Fibroma; Giant Cell Tumors; Humans; Magnetic Resonance Spectroscopy; Male; Middle Aged; Organophosphates; Osteosarcoma; Phosphocreatine; Phosphorus; Phosphorus Isotopes; Sarcoma, Ewing; Soft Tissue Neoplasms; Young Adult