phosphocreatine and Delayed-Graft-Function

phosphocreatine has been researched along with Delayed-Graft-Function* in 1 studies

Other Studies

1 other study(ies) available for phosphocreatine and Delayed-Graft-Function

ArticleYear
31P MRS of heart grafts provides metabolic markers of early dysfunction.
    European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery, 2005, Volume: 28, Issue:4

    Early graft failure (EGF) is a life-threatening event still accounting for a significant percentage of early deaths after heart transplantation. We tested whether selected metabolic markers, including high-energy phosphate concentrations measured ex vivo in pre-transplant heart grafts by (31)P magnetic resonance spectroscopy (MRS) are related with early post-transplant outcome.. During a 3-year period, 26 heart grafts harvested in the vicinity of the transplantation centre were studied. Evaluation of transplantability was done conventionally. (31)P MRS was performed ex vivo approximately 60min after aortic cross-clamp to quantify ATP, P(i) and PCr concentration ratios. A MRS-score was defined as a combination of intracellular pH (pHi) and the PCr/P(i) ratio. EGF was defined as the need to abnormally extend circulatory support or to use more than two inotropes before weaning the patient from CPB after transplantation. The grafts were attributed to three groups as follows: A1, transplanted with uneventful outcome (n=14); A2, transplanted with subsequent EGF (n=3) and B, not suitable for transplantation (n=9).. Significant differences between groups existed for the following metabolic markers: PCr/ATP (P=0.013), PCr/P(i) (P=0.0004), pHi (P=0.0016) and MRS-score (P=0.0001). The sensitivity, specificity and positive likelihood ratio for EGF with a MRS-score

    Topics: Adenosine Triphosphate; Biomarkers; Delayed Graft Function; Heart; Heart Transplantation; Humans; Magnetic Resonance Spectroscopy; Middle Aged; Phosphocreatine; Phosphorus Isotopes; Pilot Projects; Predictive Value of Tests

2005