phosphocreatine and Aortic-Coarctation

Muscle biopsies were taken from the quadriceps muscle during rest and exercise in 16 young men (ages 16-28 years) operated upon for coarctation of the aorta during childhood and 10 healthy men (ages 19-25 years). Resting values and depletion after exercise for ATP, CP and glycogen were similar in the two groups. Muscle-lactate concentrations were higher at all levels of exercise in the operated group, while blood-lactate concentrations did not differ. It is concluded that the operated patients have a disturbed blood-flow regulation and a somewhat impaired blood-flow to the working leg muscles.

Topics: Adenosine Triphosphate; Adolescent; Adult; Aortic Coarctation; Glycogen; Hemodynamics; Humans; Lactates; Male; Muscles; Oxygen Consumption; Phosphocreatine; Physical Exertion; Respiration

Muscle biopsies from the upper and the lower part of the body (m. deltoideus dx and m. vastus lat dx) were taken in young men, 17-28 years of age, who had been operated upon for coarctation of the aorta in childhood. Significant differences regarding SDH-activity and some muscle substrate levels were found, with higher values in the leg muscle. The same differences were found in ten healthy controls. It is concluded that arm and leg muscle differ in these respects but that the haemodynamic difference remaining after coarctectomy does not seem to influence this situation.

Topics: Adenosine Triphosphate; Adolescent; Adult; Aortic Coarctation; Arm; Glucose; Glycogen; Humans; L-Lactate Dehydrogenase; Lactates; Leg; Male; Muscles; Phosphocreatine; Succinate Dehydrogenase

Topics: Adenosine Triphosphate; Adolescent; Animals; Aortic Coarctation; Child; Child, Preschool; Dogs; Energy Metabolism; Humans; Hydrogen-Ion Concentration; Hypotension, Controlled; Hypoxia; Ischemia; Lactates; Membrane Potentials; Muscles; Phosphocreatine; Pyruvates; Surgical Procedures, Operative; Tourniquets

Topics: Aging; Aortic Coarctation; Atrophy; Cardiomegaly; Cell Count; Cell Membrane; Cell Physiological Phenomena; Hemodynamics; Hypertrophy; Membrane Potentials; Muscles; Myocardium; Organ Size; Phosphocreatine; Protein Biosynthesis

Topics: Acute Disease; Adaptation, Physiological; Animals; Aortic Coarctation; Cathepsins; Deoxyribonucleases; Heart; Heart Function Tests; Male; Myocardium; Phosphocreatine; Phosphoric Monoester Hydrolases; Physical Exertion; Rats; Ribonucleases; Time Factors

Topics: Adaptation, Physiological; Altitude; Animals; Aortic Coarctation; Cerebral Cortex; Disease Models, Animal; Glycogen; Heart; Heart Failure; Hypoxia; Methods; Muscle Contraction; Myocardium; Phosphocreatine; Protein Biosynthesis; Rats; RNA