phosphocreatine and Angina--Unstable

55 patients with unstable angina pectoris (group 1) received conventional treatment and neoton infusions (30 g/day for 3 days). Emoxipin was injected intramuscularly to 20 patients of group 2 (3 mg/kg for 20 days) and intravenously to 38 patients of group 3 (10 mg/kg). Control group consisted of 100 patients. Stabilization occurred in 89.2, 80 and 86.8% of group 1, 2 and 3 patients, respectively, versus 78% in controls. Holter ECG monitoring provided evidence on decline of myocardial ischemia for group 1 patients. Diene conjugates in group 1 decreased by 37%, ceruloplasmin level was higher by 30% compared to controls. Respective indices for emoxipin reached 52 and 37%, respectively. It is concluded that emoxipin and neoton produced a beneficial effect on unstable angina pectoris through correction of lipid peroxidation.

Topics: Angina, Unstable; Antioxidants; Electrocardiography, Ambulatory; Humans; Lipid Peroxidation; Middle Aged; Phosphocreatine; Picolines

We previously reported that 20% of women with chest pain but without obstructive coronary artery disease (CAD) had stress-induced reduction in myocardial phosphocreatine-adenosine triphosphate ratio by phosphorus-31 nuclear magnetic resonance spectroscopy (abnormal MRS), consistent with myocardial ischemia. The prognostic implications of these findings are unknown.. Women referred for coronary angiography for suspected myocardial ischemia underwent MRS handgrip stress testing and follow-up evaluation. These included (1) n=60 with no CAD/normal MRS, (2) n=14 with no CAD/abnormal MRS, and (3) n=352 a reference group with CAD. Cardiovascular events were death, myocardial infarction, heart failure, stroke, other vascular events, and hospitalization for unstable angina. Cumulative freedom from events at 3 years was 87%, 57%, and 52% for women with no CAD/normal MRS, no CAD/abnormal MRS, and CAD, respectively (P<0.01). After adjusting for CAD and cardiac risk factors, a phosphocreatine-adenosine triphosphate ratio decrease of 1% increased the risk of a cardiovascular event by 4% (P=0.02). The higher event rate in women with no CAD/abnormal MRS was primarily due to hospitalization for unstable angina, which is associated with repeat catheterization and higher healthcare costs.. Among women without CAD, abnormal MRS consistent with myocardial ischemia predicted cardiovascular outcome, notably higher rates of anginal hospitalization, repeat catheterization, and greater treatment costs. Further evaluation into the underlying pathophysiology and possible treatment options for women with evidence of myocardial ischemia but without CAD is indicated.

Topics: Adenosine Triphosphate; Aged; Angina, Unstable; Cardiac Catheterization; Cohort Studies; Coronary Angiography; Coronary Stenosis; Cost-Benefit Analysis; Disease-Free Survival; Female; Follow-Up Studies; Hand Strength; Health Care Costs; Heart Failure; Hospitalization; Humans; Life Tables; Magnetic Resonance Spectroscopy; Middle Aged; Myocardial Infarction; Myocardial Ischemia; Myocardium; Outcome Assessment, Health Care; Phosphocreatine; Prognosis; Risk Factors; Stroke; United States

Topics: Angina, Unstable; Drug Evaluation; Electrocardiography; Hemodynamics; Humans; Lipid Peroxidation; Middle Aged; Phosphocreatine; Time Factors

A total of 485 patients with complicated myocardial infarction (MI) in the presence of concurrent abnormality and 104 patients with unstable angina (UA) were followed up. Intravenous infusion of neoton (phosphocreatine) in a dose of 70 g at day 1 and 36 g at days 2 and 3 of the onset was made in 96 patients with MI, 28 patients with UA took neoton in a daily dose of 30 g during 3 days. Control patients had conventional therapy, In UA, poor outcomes (death, MI, no effects, referral of patients for bypass surgery) were seen in 4 (14%) patients on the drug and in 18 (28%) in the controls (p > 0.05). In MI, more rapid disappearance of events (heart failure and tachyarrhythmias) was observed in the major group, the mortality being 23.9%, the incidence of cardiac ruptures 6.4 versus 33.6 and 12.6% respectively, in the control. It is concluded that large-dose neoton exerts positive action on the cause and outcome of UA and complicated MI.

Topics: Adult; Angina, Unstable; Drug Evaluation; Drug Therapy, Combination; Female; Humans; Male; Middle Aged; Myocardial Infarction; Phosphocreatine; Time Factors; Treatment Outcome