phosphocreatine and Alcohol-Amnestic-Disorder

Thiamine deficiency (TD) in rats produces lesions similar to those found in humans suffering from Wernicke's encephalopathy, an organic mental disorder associated with alcoholism. Male Sprague-Dawley rats (n = 29) were deprived of thiamine via a regimen of thiamine-deficient chow and daily intraperitoneal injections of the thiamine antagonist pyrithiamine hydrobromide. Spectra were obtained by using the STEAM sequence. No significant change occurred in the ratio of Cr/NAA, while the ratio of Cho/NAA declined significantly (60 +/- 11%) on Day 14. Eleven rats received intraperitoneal injections of thiamine hydrochloride at the end of 12 days, and dose-dependent recovery in Cho/NAA was observed.

Topics: Alcohol Amnestic Disorder; Animals; Brain; Creatine; Dipeptides; Dose-Response Relationship, Drug; Glutamic Acid; Magnetic Resonance Spectroscopy; Male; Phosphocreatine; Rats; Rats, Sprague-Dawley; Thiamine; Thiamine Deficiency; Wernicke Encephalopathy