phosphatidylinositol-4-phosphate has been researched along with Renal-Insufficiency* in 1 studies
1 review(s) available for phosphatidylinositol-4-phosphate and Renal-Insufficiency
| Article | Year |
|---|---|
The function of apolipoproteins L (APOLs): relevance for kidney disease, neurotransmission disorders, cancer and viral infection.
The discovery that apolipoprotein L1 (APOL1) is the trypanolytic factor of human serum raised interest about the function of APOLs, especially following the unexpected finding that in addition to their protective action against sleeping sickness, APOL1 C-terminal variants also cause kidney disease. Based on the analysis of the structure and trypanolytic activity of APOL1, it was proposed that APOLs could function as ion channels of intracellular membranes and be involved in mechanisms triggering programmed cell death. In this review, the recent finding that APOL1 and APOL3 inversely control the synthesis of phosphatidylinositol-4-phosphate (PI(4)P) by the Golgi PI(4)-kinase IIIB (PI4KB) is commented. APOL3 promotes Ca Topics: Actomyosin; Animals; Apolipoprotein L1; Apolipoproteins L; Autistic Disorder; Autophagosomes; Calcium; Gene Expression Regulation; Golgi Apparatus; Humans; Neoplasms; Phosphatidylinositol Phosphates; Phosphotransferases (Alcohol Group Acceptor); Renal Insufficiency; Schizophrenia; Trypanosomiasis, African; Virus Diseases | 2021 |