Compounds > phosphatidylinositol-4-phosphate

phosphatidylinositol-4-phosphate and Leukemia--Erythroblastic--Acute

phosphatidylinositol-4-phosphate has been researched along with Leukemia--Erythroblastic--Acute* in 2 studies

Other Studies

2 other study(ies) available for phosphatidylinositol-4-phosphate and Leukemia--Erythroblastic--Acute

Article	Year
Inositides in nuclei of Friend cells: changes of polyphosphoinositide and diacylglycerol levels accompany cell differentiation. Cellular signalling, 1995, Volume: 7, Issue:1 Friend erythroleukemia cells were labelled with high levels of [3H]myo-inositol and the radioactivity in PI, PIP and PIP2, extracted from isolated nuclei, was measured. A parallel analysis employing a picomole sensitive assay for both PIP and DAG has been carried out. The results indicate that the differentiation process is characterised by an accumulation of nuclear PIP and PIP2 and by a decrease of DAG mass. We suggest that as differentiation proceeds toward erythrocytes in Friend cells, this is accompanied by a reduction in the amount of these messengers in the nucleus. Topics: Animals; Cell Differentiation; Cell Nucleus; Cell Transformation, Viral; Diglycerides; Friend murine leukemia virus; Leukemia, Erythroblastic, Acute; Leukemia, Experimental; Mice; Phosphatidylinositol 4,5-Diphosphate; Phosphatidylinositol Phosphates; Phosphatidylinositols; Tumor Cells, Cultured	1995
Inositol lipid metabolism accompanies erythroid differentiation of K562 human leukemic cells. Leukemia research, 1991, Volume: 15, Issue:6 The role of hemin induction of K562 in inositol phospholipid metabolism has not been previously studied. K562 cells were induced to synthesize hemoglobin upon addition of bovine hemin to the culture media. The phospholipid content of K562 was determined before and after the addition of hemin. The results of this study demonstrated significant differences in the phosphoinositides between induced and non-induced cells. Phosphatidylinositol-4-phosphate (PIP) and phosphatidyl-inositol-4,5-bisphosphate (PIP2) levels increased upon induction, and remained above control levels. Phosphatidylinositol (PI) levels decreased 15 min after hemin addition, then increased to control levels by 1 h. From 2-8 h PI levels then remained depressed below control levels. These data suggest that hemoglobin induction in K562 cells occurs concomitantly with inositol phospholipid turnover. Topics: Cell Differentiation; Erythroid Precursor Cells; Hemin; Hemoglobins; Humans; Leukemia, Erythroblastic, Acute; Leukemia, Experimental; Phosphatidylinositol 4,5-Diphosphate; Phosphatidylinositol Phosphates; Phosphatidylinositols; Tumor Cells, Cultured	1991

Article

Year

Inositides in nuclei of Friend cells: changes of polyphosphoinositide and diacylglycerol levels accompany cell differentiation.

Cellular signalling, 1995, Volume: 7, Issue:1

Friend erythroleukemia cells were labelled with high levels of [3H]myo-inositol and the radioactivity in PI, PIP and PIP2, extracted from isolated nuclei, was measured. A parallel analysis employing a picomole sensitive assay for both PIP and DAG has been carried out. The results indicate that the differentiation process is characterised by an accumulation of nuclear PIP and PIP2 and by a decrease of DAG mass. We suggest that as differentiation proceeds toward erythrocytes in Friend cells, this is accompanied by a reduction in the amount of these messengers in the nucleus.

Topics: Animals; Cell Differentiation; Cell Nucleus; Cell Transformation, Viral; Diglycerides; Friend murine leukemia virus; Leukemia, Erythroblastic, Acute; Leukemia, Experimental; Mice; Phosphatidylinositol 4,5-Diphosphate; Phosphatidylinositol Phosphates; Phosphatidylinositols; Tumor Cells, Cultured

1995

Inositol lipid metabolism accompanies erythroid differentiation of K562 human leukemic cells.

Leukemia research, 1991, Volume: 15, Issue:6

The role of hemin induction of K562 in inositol phospholipid metabolism has not been previously studied. K562 cells were induced to synthesize hemoglobin upon addition of bovine hemin to the culture media. The phospholipid content of K562 was determined before and after the addition of hemin. The results of this study demonstrated significant differences in the phosphoinositides between induced and non-induced cells. Phosphatidylinositol-4-phosphate (PIP) and phosphatidyl-inositol-4,5-bisphosphate (PIP2) levels increased upon induction, and remained above control levels. Phosphatidylinositol (PI) levels decreased 15 min after hemin addition, then increased to control levels by 1 h. From 2-8 h PI levels then remained depressed below control levels. These data suggest that hemoglobin induction in K562 cells occurs concomitantly with inositol phospholipid turnover.

Topics: Cell Differentiation; Erythroid Precursor Cells; Hemin; Hemoglobins; Humans; Leukemia, Erythroblastic, Acute; Leukemia, Experimental; Phosphatidylinositol 4,5-Diphosphate; Phosphatidylinositol Phosphates; Phosphatidylinositols; Tumor Cells, Cultured

1991