phosphatidylinositol-4-phosphate has been researched along with Hypertrophy* in 1 studies
1 other study(ies) available for phosphatidylinositol-4-phosphate and Hypertrophy
| Article | Year |
|---|---|
Compensatory changes in calcium uptake and phospholipid composition in rat renal brush border membranes after unilateral nephrectomy.
Unilateral nephrectomy (uNX) induces a decrease in calcium uptake by brush border membranes (BBM) in the remnant kidney compared to control membranes. This effect was found to occur within 48 h and persisted at 2 weeks after uNX. Moreover, this decreased calcium uptake appears to occur through a diminished binding capacity of the BBM. Our studies also show that renal hypertrophy induced a specific decrease in the content of acidic phospholipids in remnant kidney BBM by 48 h after uNX. The decrease in phosphatidylinositol 4,5-bisphosphate and phosphatidic acid was transitory but phosphatidylinositol 4-monophosphate levels remained lower in the BBM at 2 weeks after uNX compared to control membranes. These results suggest that the decreased calcium uptake by remnant kidney BBM after uNX is related to a decreased membrane content of acidic phospholipids. This effect might account, at least in part, for the decrease in fractional calcium reabsorption during renal compensatory hypertrophy. Topics: Animals; Calcium; Female; Hypertrophy; Kidney; Kinetics; Microvilli; Nephrectomy; Phosphatidic Acids; Phosphatidylinositol Phosphates; Phosphatidylinositols; Phospholipids; Rats; Rats, Inbred Strains | 1988 |