phosphatidylethanol has been researched along with Liver-Diseases--Alcoholic* in 2 studies
1 review(s) available for phosphatidylethanol and Liver-Diseases--Alcoholic
| Article | Year |
|---|---|
Assessing the drinking status of liver transplant patients with alcoholic liver disease.
The accurate assessment of drinking by patients with alcoholic liver disease is important both before and after liver transplantation. Unfortunately, self-reports by these individuals often underestimate their actual alcohol consumption. Several recently developed biochemical measures can provide additional information on a patient's use of alcohol. This article describes ethyl glucuronide, ethyl sulfate, phosphatidyl ethanol, and carbohydrate-deficient transferrin as biomarkers of drinking and summarizes research dealing with their application in patients with alcohol use disorders who are candidates for or recipients of liver transplantation. The article also offers suggestions for enhancing the reliability of self-report measures of drinking status. Topics: Alcohol Drinking; Biomarkers; Glucuronates; Glycerophospholipids; Humans; Liver Diseases, Alcoholic; Liver Transplantation; Predictive Value of Tests; Reproducibility of Results; Self Report; Sulfuric Acid Esters; Temperance; Transferrin; Treatment Outcome; Waiting Lists | 2013 |
1 other study(ies) available for phosphatidylethanol and Liver-Diseases--Alcoholic
| Article | Year |
|---|---|
Improved detection of alcohol consumption using the novel marker phosphatidylethanol in the transplant setting: results of a prospective study.
Phosphatidylethanol (PEth) is a new, highly specific alcohol marker. The aim of this study was to assess its diagnostic value in the liver transplant setting. In 51 pre- and 61 post-transplant patients with underlying alcoholic liver disease PEth, ethanol, methanol, carbohydrate-deficient transferrin (CDT), and ethyl glucuronide in urine (uEtG) and hair (hEtG) were tested and compared with patients' questionnaire reports. Twenty-eight (25%) patients tested positive for at least one alcohol marker. PEth alone revealed alcohol consumption in 18% of patients. With respect to detection of alcohol intake in the preceding week, PEth showed a 100% sensitivity. PEth testing was more sensitive than the determination of ethanol, methanol, CDT or uEtG alone [sensitivity 25% (confidence interval (CI) 95%, 7-52%), 25% (7-52%), 21% (6-45%) and 71% (41-91%), respectively], or ethanol, methanol and uEtG taken in combination with 73% (45-92%). Specificity of all markers was 92% or higher. Additional testing of hEtG revealed alcohol consumption in seven patients, not being positive for any other marker. Phosphatidylethanol was a highly specific and sensitive marker for detection of recent alcohol consumption in pre- and post-transplant patients. The additional determination of hEtG was useful in disclosing alcohol consumption 3-6 months retrospectively. Topics: Adult; Aged; Alcohol Drinking; Biomarkers; Ethanol; False Positive Reactions; Female; Glucuronates; Glycerophospholipids; Hair; Humans; Liver Diseases, Alcoholic; Liver Transplantation; Male; Methanol; Middle Aged; Prospective Studies; Retrospective Studies; Sensitivity and Specificity; Surveys and Questionnaires; Transferrin | 2017 |