phosphatidylcholines has been researched along with Alzheimer Disease in 171 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 61 (35.67) | 18.7374 |
| 1990's | 27 (15.79) | 18.2507 |
| 2000's | 24 (14.04) | 29.6817 |
| 2010's | 45 (26.32) | 24.3611 |
| 2020's | 14 (8.19) | 2.80 |
| Authors | Studies |
|---|---|
| Huang, H; Yuan, R | 1 |
| Fonteh, A; Hafez, M; Harrington, MG; Solomon, V; Xian, H; Yassine, HN | 1 |
| Arita, T; Fujino, T; Fukata, M; Kono, S; Maruyama, T; Mawatari, S | 1 |
| Kurouski, D; Matveyenka, M; Zhaliazka, K | 1 |
| Blusztajn, JK; Slack, BE | 1 |
| Ding, L; Teruyoshi, Y; Wang, Y; Wen, M; Xue, C; Zhang, L; Zhang, T | 1 |
| Chi, N; Cong, PX; Liu, FH; Wang, YM; Xu, J; Xue, CH; Yanagita, T; Zhang, LY; Zhang, TT; Zhao, YC; Zhou, MM | 1 |
| Dey, M; Gunn-Moore, FJ; Platt, B; Smith, TK | 1 |
| Devanarayan, P; Devanarayan, V; Issa, LK; Llano, DA | 1 |
| Ausili, A; Beltrán, A; Candel, AM; Gómez-Fernández, JC; Gómez-Murcia, V; He, L; Jiang, Y; Teruel, JA; Torrecillas, A; Zhang, S | 1 |
| Chodaczek, G; Drabik, D; Kraszewski, S | 1 |
| Cong, PX; Wang, YM; Wei, ZH; Xu, J; Xue, CH; Yanagita, T; Zhang, C; Zhang, TT; Zhou, MM | 1 |
| Blasko, I; Defrancesco, M; Humpel, C; Kemmler, G; Loacker, L; Marksteiner, J; Oberacher, H | 1 |
| Du, D; Kent, TW; Morris, C; Shen, F; Wojcikiewicz, EP | 1 |
| Jiaranaikulwanitch, J; Jiranusornkul, S; Saenjum, C; Vajragupta, O; Wongrattanakamon, P; Yooin, W | 1 |
| Arnold, M; Baillie, RA; Blach, C; Casanova, R; Chang, R; Dallmann, G; Demirkan, A; Doraiswamy, PM; Han, X; Hankemeier, T; Harms, AC; Henrion, MYR; Jack, JR; John-Williams, LS; Kaddurah-Daouk, R; Kastenmüller, G; Kim, S; Klavins, K; Koal, T; Legido-Quigley, C; Louie, G; Lucas, JE; MahmoudianDehkordi, S; Massaro, T; Moseley, MA; Motsinger-Reif, A; Nho, K; Risacher, SL; Rotroff, DM; Saykin, AJ; Shaw, LM; Shen, L; Suhre, K; Tenenbaum, JD; Thambisetty, M; Thompson, JW; Toledo, JB; Trojanowski, JQ; van der Lee, SJ; van Duijn, CM; Varma, S; Weiner, MW; Zhu, H; Zhu, K | 1 |
| Akatsu, H; Arai, H; Fukumoto, M; Kioka, N; Kono, N; Mañucat, NB; Toda, Y; Tomioka, M; Ueda, K | 1 |
| Björkeroth, J; Esbjörner, EK; Lindberg, DJ; Rocha, S; Wesén, E | 1 |
| Goto, Y; Ikenoue, T; Kakimoto, E; Kinoshita, M; Lee, YH; Lin, Y; Ramamoorthy, A; So, M; Sugiki, T; Terakawa, MS | 1 |
| Che, H; Ding, L; Wang, Y; Xu, J; Xue, C; Yanagita, T; Zhang, L; Zhang, T; Zhou, M | 1 |
| Au, R; Blusztajn, JK; Chen, X; Kowall, N; Qiu, WQ; Stern, RA; Tao, Q; Zhu, H | 1 |
| Chang, Y; Cong, P; Ding, L; Wang, Y; Wen, M; Xu, J; Xue, C; Zhang, L; Zhang, T | 1 |
| Patrick, RP | 1 |
| Humpel, C; Marksteiner, J; Oberacher, H | 1 |
| Bobo, C; Cullin, C; Ewald, M; Feuillie, C; Henry, S; Lambert, E; Lecomte, S; Molinari, M | 1 |
| Bui, HH; Fett, AR; Hagen, C; Jack, CR; Knopman, D; Li, D; Machulda, MM; Mielke, MM; Petersen, RC; Vemuri, P | 1 |
| Pan, Q; Wang, Q; Yu, X; Zheng, J; Zhou, F | 1 |
| Galliani, A; Meleleo, D; Notarachille, G | 1 |
| Bulone, D; Canale, C; Carrotta, R; Dante, S; Diaspro, A; San Biagio, PL; Seghezza, S; Vilasi, S | 1 |
| Arce, FT; Jang, H; Kagan, BL; Lal, R; Nussinov, R; Ramachandran, S | 1 |
| García-Gómez, D; Heaton, J; Kloszewska, I; Legido-Quigley, C; Leung, R; Lovestone, S; Mecocci, P; Proitsi, P; Sen, A; Smith, N; Soininen, H; Thambisetty, M; Tsolaki, M; Vellas, B; Whiley, L | 1 |
| Berlau, DJ; Cheema, AK; Federoff, HJ; Fiandaca, MS; Fisher, SG; Haley, JM; Hall, WJ; Kawas, CH; MacArthur, LH; Mapstone, M; Mhyre, TR; Nazar, MD; Peltz, CB; Peterson, DR; Rich, SA; Tan, MT; Zhong, X | 1 |
| Akatsu, H; Kinoshita, A; Kon, R; Maesako, M; Setou, M; Sugiura, Y; Sugiyama, K; Takei, S; Yamamoto, T; Yao, I; Yuki, D; Zaima, N | 1 |
| Albonetti, C; Bobba, F; Cucolo, A; D'Ursi, AM; Grimaldi, M; Nori, SL; Scrima, M; Sublimi Saponetti, M | 1 |
| Brooks, BR; Buchete, NV; Tofoleanu, F | 1 |
| Castro, M; Monteiro-Cardoso, VF; Moreira, PI; Oliveira, MM; Peixoto, F; Videira, RA | 1 |
| Gao, Z; Han, H; Qu, MH; Tang, Q; Wang, GD; Wang, J; Wang, Y; Xue, C; Yang, X | 1 |
| Wurtman, RJ | 1 |
| Beason-Held, L; Chuang, YF; Griswold, ME; Kim, M; Kitner-Triolo, M; Kraut, M; Legido-Quigley, C; Lirette, ST; Simpson, BN; Thambisetty, M; Windham, BG | 1 |
| Calzada, E; Claypool, SM; Onguka, O | 1 |
| Chiang, J; Chui, HC; Feng, Q; Fonteh, AN; Harrington, MG; Petrosspour, LM; Yassine, HN | 1 |
| Goodenowe, DB; Jayasinge, D; Ritchie, SA; Wang, L | 1 |
| Dobson, RJB; Kim, M; Kloszewska, I; Legido-Quigley, C; Lovestone, S; Lupton, MK; Mecocci, P; Nevado-Holgado, A; Powell, JF; Proitsi, P; Simmons, A; Snowden, SG; Soininen, H; Thambisetty, M; Tsolaki, M; Velayudhan, L; Vellas, B; Whiley, L | 1 |
| Jemiola-Rzeminska, M; Strzalka, K; Suwalsky, M; Villena, F; Zambrano, P | 1 |
| Bhunia, A; Dulchavsky, M; Ivanova, MI; Korshavn, KJ; La Rosa, C; Lee, YH; Lim, MH; Lin, Y; Ramamoorthy, A; Satriano, C; Zhang, R | 1 |
| Arnhard, K; Diwo, A; Humpel, C; Linhart, C; Marksteiner, J; Oberacher, H | 1 |
| Blennow, K; Chalbot, S; Fladby, T; Grundke-Iqbal, I; Iqbal, K; Zetterberg, H | 1 |
| Bennett, SA; Blanchard, AP; Bourgeois, AJ; Ethier, M; Figeys, D; Fraser, PE; Hou, W; Moffat, TC; Park, DS; Rashidian, J; Ryan, SD; Swayne, LA; Whitehead, SN | 1 |
| Kotarek, JA; Moss, MA | 1 |
| Hamada, T; Morita, M; Takagi, M; Vestergaard, M | 1 |
| Miura, T; Murayama, K; Takeuchi, H; Tsutsumi, C; Yoda, M | 1 |
| Antimisiaris, SG; Canovi, M; Clemente, C; Duyckaerts, C; Flores, O; Gobbi, M; Lazar, AN; Markoutsa, E; Masserini, M; Pampalakis, G; Re, F; Salmona, M; Sesana, S | 1 |
| Bevan, DR; Lemkul, JA | 1 |
| Johnson, S; Leblanc, RM; Micic, M; Pao, C; Thakur, G | 1 |
| Argyri, L; Chroni, A; Skamnaki, V; Stratikos, E | 1 |
| Grimm, HS; Grimm, MO; Grösgen, S; Hartmann, T; Riemenschneider, M; Tanila, H | 1 |
| Giordani, C; Hovgaard, MB; Jarvis, SP; McManus, JJ; Sheikh, K | 1 |
| Luo, G; Shi, J; Wang, Y | 1 |
| Barré, P; Eliezer, D; Huster, D; Künze, G; Scheidt, HA; Thomas, L | 1 |
| Kukol, A; Poojari, C; Strodel, B | 1 |
| Chan, CL; Ho, HM; Hu, P; Jiang, ZH; Liu, L; Wang, JR; Yau, LF; Zhang, H | 1 |
| Dante, S; Dencher, NA; Hauss, T | 1 |
| Kakio, A; Kozutsumi, Y; Matsuzaki, K; Nishimoto, S | 1 |
| Cahill, L; Gold, PE; Wenk, GL | 1 |
| Blomberg, M; Mulder, C; Scheffer, PG; Scheltens, P; Teerlink, T; van Kamp, GJ; Veerhuis, R; Wahlund, LO | 1 |
| Flicker, L; Higgins, JP | 3 |
| Butler, R; Prabhakaran, P; Warner, J | 1 |
| FELDMAN, G; GALLI, C; ROUSER, G | 1 |
| Cheng, H; Han, X; McKeel, DW; Xu, J | 1 |
| Ambroggio, EE; Bagatolli, LA; Barnham, KJ; Barrow, CJ; Fidelio, GD; Kim, DH; Separovic, F | 1 |
| Alarcón, JM; Atwater, I; Brito, JA; Hermosilla, T; Mears, D; Rojas, E | 1 |
| Ambroggio, EE; Barnham, KJ; Cappai, R; Fidelio, GD; Lau, TL; Masters, CL; Separovic, F; Tew, DJ | 1 |
| Angel, I; Dahan, A; Duvdevani, R; Dvir, E; Friedman, JE; Hoffman, A; Koh, JY; Kozak, A; Lee, JY; Raz, S; Rosenberg, G; Shapiro, I; Younis, F | 1 |
| Appel, TR; Davies, P; Diekmann, S; Gellermann, GP | 1 |
| Choi, EK; Jin, JK; Kim, HS; Kim, NH; Kim, YS; Kozlowski, PB; Lee, YJ; Min, do S; Park, MH | 1 |
| Au, R; Beiser, AS; Bongard, V; Kyle, DJ; Lamon-Fava, S; Robins, SJ; Schaefer, EJ; Tucker, KL; Wilson, PW; Wolf, PA | 1 |
| Dahan, A; Duvdevani, R; Dvir, E; Elman, A; Friedman, JE; Hoffman, A; Shapiro, I; Simmons, D | 1 |
| Jolles, J; Verhoeven, WM | 1 |
| Levy, R | 3 |
| Chuaqui, P; Levy, R; Little, A; Reith, M | 1 |
| Davies, P | 1 |
| Davis, KL; Rosenberg, GS | 1 |
| Gershon, S; Goodnick, P | 1 |
| Fuld, PA; Masur, DM; Sharpless, NS; Thal, LJ | 1 |
| Albert, MS; Auty, R; Baratz, R; Cholakos, BN; Kapust, L; LoCastro, S; Mesulam, MM; Moss, M; Ransil, B; Tellers, JG; Weintraub, S | 1 |
| Conner, CS; Rathmann, KL | 1 |
| Johnson, R; Morgan, R; Smith, RC; Vroulis, G | 1 |
| Ford, DI; Marco, LA; Mitchell, R; Plesnarski, J; Randels, PM; Scholl, M | 1 |
| King, RG | 1 |
| Graham, HN; Growdon, JH; Wheeler, S | 1 |
| Davies, P; Fuld, PA; Masur, DM; Sharpless, NS; Thal, LJ | 2 |
| Levin, HS; Peters, BH | 2 |
| Blass, JP | 1 |
| Marchbanks, RM | 1 |
| Wettstein, A | 1 |
| Brinkman, S; Domino, EF; Gershon, S; Pomara, N; Tamminga, CA; Yoon, H | 1 |
| Davis, JM; Dysken, MW; Fovall, P; Harris, CM; Noronha, A | 1 |
| Canter, NL; Growdon, JH; Hallett, M | 1 |
| Colhoun, EH; Fisman, M; Helmes, E; McCready, J; Merskey, H; Rylett, BJ | 1 |
| Allen, RH; Brinkman, SD; Gordon, JR; Meyer, JS; Shaw, T; Smith, RC; Vroulis, G | 1 |
| Bartus, RT; Beer, B; Dean, RL; Lippa, AS | 1 |
| Chuaqui, P; Levy, R | 1 |
| Claghorn, J; Ho, BT; Hsu, L; Schoolar, J; Smith, RC; Vroulis, G | 1 |
| Barnett, N; Brinkman, SD; Domino, EF; Goodnick, PJ; Pomara, N | 1 |
| Dahlen, G; Katz, E; Misra, CH; Schoolar, JC; Smith, RC; Vroulis, G | 1 |
| Collier, B; Dastoor, D; Etienne, P; Gauthier, S; Ludwick, R | 1 |
| Brinkman, S; Gordon, J; Schoolar, J; Smith, RC; Vroulis, GA | 1 |
| Christie, JE; Glen, AI; Jellinek, EH; Shering, A; Simpson, J; Whalley, LJ; Yates, CM | 1 |
| Corkin, S; Growdon, JH | 1 |
| Holford, NH; Peace, K | 1 |
| Cowburn, R; Messamore, E; O'Neill, C; Winblad, B | 1 |
| Broe, GA; Brooks, WS; Christensen, H; Creasey, H; Jorm, AF; Maltby, N | 1 |
| Boyle, M; Mulligan, K; Neubauer, KA; O'Neill, D; Royston, VH; Scott, M; Surmon, DJ; Wilcock, GK | 1 |
| Gauthier, L; Gauthier, S | 1 |
| Fitten, LJ; Perryman, KM | 1 |
| Mason, PE; Mason, RP; Walter, MF | 1 |
| Dhillon, H; Lovell, MA; Markesbery, WR; Prasad, MR; Yatin, M | 1 |
| Gershfeld, NL; Ginsberg, L; Xuereb, JH | 1 |
| Besson, JA; Cooper, MB; Corrigan, FM; Horrobin, DF; Skinner, ER | 1 |
| di Fazio, I; Malaguarnera, M; Motta, M; Pistone, G; Rampello, L; Vinci, M | 1 |
| Guan, ZZ; Hu, PS; Liu, JL; Wang, YN; Xiao, KQ | 1 |
| Cairns, NJ; Dallner, G; Guan, Z; Lantos, PL; Sindelar, PJ; Wang, Y | 1 |
| Beiser, A; Kyle, DJ; Patton, G; Schaefer, E | 1 |
| Blusztajn, JK; Farber, SA; Slack, BE | 1 |
| Bettger, WJ; Conquer, JA; Fisher, RH; Tierney, MC; Zecevic, J | 1 |
| Alberghina, M; Anfuso, CD; Assero, G; Lupo, G; Pluta, R; Strosznajder, RP; Walski, M | 1 |
| Fan, QW; Gong, JS; Michikawa, M; Sawamura, N; Yanagisawa, K | 1 |
| Hamilton, J; Igbavboa, U; Kim, HY; Sun, GY; Wood, WG | 1 |
| Perry, EK; Perry, RH; Tomlinson, BE | 1 |
| Collier, B; Dastoor, D; Etienne, P; Gauthier, S; Ratner, J | 1 |
| Kent, S | 1 |
| Fitten, LJ; Ganzell, S | 1 |
| Cohen, MB; Fitten, LJ; Graham, LS; Lake, RR; Perryman, KM; Sevrin, R | 1 |
| Jones, GM; Levy, R; Rebeiro, A; Uney, JB | 1 |
| Eagger, SA; Levy, R; Sahakian, BJ | 1 |
| Dallner, G; Edlund, C; Kristensson, K; Söderberg, M | 1 |
| Teunisse, S; van Gool, WA; Weinstein, HC | 1 |
| Volger, BW | 1 |
| Beckmann, H; Burger, R; Frölich, L; Götz, M; Heckers, S; Jellinger, K; Riederer, P; Sofic, E | 1 |
| Chatellier, G; Lacomblez, L | 1 |
| Bacher, Y; Bailey, P; Bergman, H; Bouchard, R; Carrier, L; Gauthier, S; Lamontagne, A; Ratner, J; Saint-Martin, M; Tesfaye, Y | 1 |
| Cummins, J; Fine, H; Fitten, LJ; Gross, PL; Marshall, C; Perryman, KM | 1 |
| Ericsson, K; Forssell, LG; Hellström, A; Winblad, B | 1 |
| Gauthier, L; Gauthier, S; Vida, S | 1 |
| Bacher, Y; Bailey, P; Bergman, H; Bouchard, R; Carrier, L; Charbonneau, R; Clarfield, M; Collier, B; Dastoor, D; Gauthier, S | 1 |
| Boller, F; Forette, F | 1 |
| Berry, IR; Borkan, L | 1 |
| Siow, BL | 1 |
| Leathwood, PD | 1 |
| Ohtomo, E | 1 |
| Leathwood, PD; Schlosser, B | 1 |
| Joyce, E; Lishman, WA; Sahakian, B | 1 |
| Gwyther, L; Heyman, A; Holloway, D; Krishnan, R; Peoples, R; Rogers, H; Schmechel, D; Schultz, K; Utley, C; Wilkinson, W | 1 |
| Albert, M; Duffy, FH; Durwen, H; McAnulty, G; Weintraub, S | 1 |
| Albert, MS; Gunther, J; Heller, H; Jenike, MA; LoCastro, S | 1 |
| Kurz, A; Romero, B; Rüster, P; Zimmer, R | 1 |
| Davidson, M; Davis, KL; Hollander, E; Mohs, RC; Powchik, P; Ryan, T; Zemishlany, Z | 1 |
| Corkin, S; Growdon, JH; Huff, FJ | 1 |
| Samorajski, T; Smith, RC; Vroulis, GA | 1 |
| Chuaqui-Kidd, P; Hand, D; Levy, R; Little, A | 1 |
| Beaumont, DM; James, OF | 1 |
| Chernitskaia, II; Gorodkova, TM; Polishchuk, IA | 1 |
28 review(s) available for phosphatidylcholines and Alzheimer Disease
| Article | Year |
|---|---|
Role of phosphatidylcholine-DHA in preventing APOE4-associated Alzheimer's disease.
Topics: Alzheimer Disease; Apolipoprotein E4; Biological Transport; Brain; Diet; Docosahexaenoic Acids; Gene-Environment Interaction; Genetic Carrier Screening; Genetic Predisposition to Disease; Humans; Phosphatidylcholines | 2019 |
How Anticholinergic Drugs Might Promote Alzheimer's Disease: More Amyloid-β and Less Phosphatidylcholine.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Brain; Cholinergic Antagonists; Humans; Phosphatidylcholines | 2015 |
Phosphatidylethanolamine Metabolism in Health and Disease.
Topics: Alzheimer Disease; Animals; Autophagy; Candida; Carboxy-Lyases; Cell Membrane; Cytidine Diphosphate; Ethanolamines; Humans; Lipid Metabolism; Methylation; Mitochondria; Non-alcoholic Fatty Liver Disease; Oxidative Phosphorylation; Parkinson Disease; Phosphatidylcholines; Phosphatidylethanolamines; Phospholipids; Prions; Protein Processing, Post-Translational; Virulence | 2016 |
[Conformational regulation of amyloid beta-peptide by lipid membranes and metal ions].
Topics: Alzheimer Disease; Amyloid beta-Peptides; Binding Sites; Copper; Humans; Ions; Membrane Lipids; Phosphatidylcholines; Protein Binding; Protein Conformation; Spectrum Analysis, Raman; Zinc | 2010 |
Lecithin for dementia and cognitive impairment.
Topics: Alzheimer Disease; Cognition Disorders; Dementia; Humans; Phosphatidylcholines; Randomized Controlled Trials as Topic | 2003 |
Dementia.
Topics: Alzheimer Disease; Anticonvulsants; Antipsychotic Agents; Carbamates; Donepezil; Galantamine; Ginkgo biloba; Humans; Indans; Nootropic Agents; Phenylcarbamates; Phosphatidylcholines; Physostigmine; Phytotherapy; Piperidines; Rivastigmine; Tacrine; Vitamin E | 2003 |
DP-155, a lecithin derivative of indomethacin, is a novel nonsteroidal antiinflammatory drug for analgesia and Alzheimer's disease therapy.
Topics: Alzheimer Disease; Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase 2; Drug Combinations; Group II Phospholipases A2; Humans; Indomethacin; Phosphatidylcholines; Phospholipases A; Phospholipases A2; Rats | 2007 |
[Psychopharmacologic treatment of cognitive function disorders in aging persons: current possibilities].
Topics: Adrenocorticotropic Hormone; Aged; Alzheimer Disease; Anticonvulsants; Brain; Catecholamines; Choline; Dementia; Dihydroergotoxine; Humans; Memory Disorders; Narcotic Antagonists; Nerve Tissue Proteins; Neuropsychology; Parasympatholytics; Phosphatidylcholines; Physostigmine; Piracetam; Trace Elements; Vasopressins; Vitamins | 1984 |
An update on the neurochemistry of Alzheimer disease.
Topics: Acetylcholinesterase; Alzheimer Disease; Arecoline; Brain; Choline; Choline O-Acetyltransferase; Cholinergic Fibers; Dementia; Dopamine; gamma-Aminobutyric Acid; Humans; Neurotransmitter Agents; Norepinephrine; Peptides; Phosphatidylcholines; Physostigmine; Serotonin | 1983 |
The use of cholinergic precursors in neuropsychiatric diseases.
Topics: Acetylcholine; Alzheimer Disease; Animals; Bipolar Disorder; Brain; Cerebellar Ataxia; Choline; Humans; Huntington Disease; Memory; Phosphatidylcholines; Psychotic Disorders; Schizophrenia; Tourette Syndrome | 1982 |
Chemotherapy of cognitive disorders in geriatric subjects.
Topics: Adrenocorticotropic Hormone; Aged; Aging; Alzheimer Disease; Arecoline; Brain Chemistry; Choline; Cognition Disorders; Cyclandelate; Electroencephalography; Humans; Memory; Methylphenidate; Pentylenetetrazole; Phosphatidylcholines; Physostigmine; Piracetam; Procaine; Vasodilator Agents; Vasopressins | 1984 |
Alzheimer's disease: clinical features, pathogenesis, and treatment.
Topics: Acetylcholine; Alzheimer Disease; Choline; Cholinesterase Inhibitors; Humans; Parasympathomimetics; Phosphatidylcholines | 1984 |
Dementia.
Topics: Alzheimer Disease; Dementia; Humans; Learning; Memory; Phosphatidylcholines; Vasodilator Agents | 1982 |
Biochemistry of Alzheimer's dementia.
Topics: Acetylcholine; Acetylcholinesterase; Alzheimer Disease; Animals; Brain; Cerebral Cortex; Choline; Choline O-Acetyltransferase; Cholinesterase Inhibitors; Dementia; Dopamine; Dopamine beta-Hydroxylase; Glutamate Decarboxylase; Glycolysis; Humans; Learning; Memory; Neurons; Norepinephrine; Parasympathomimetics; Phosphatidylcholines; Pyruvate Dehydrogenase Complex Deficiency Disease | 1982 |
Lecithin and memory training in suspected Alzheimer's disease.
Topics: Aged; Alzheimer Disease; Cerebrovascular Circulation; Dementia; Female; Humans; Male; Memory; Middle Aged; Phosphatidylcholines; Psychotherapy | 1982 |
The cholinergic hypothesis of geriatric memory dysfunction.
Topics: Acetylcholine; Adult; Aged; Aging; Alzheimer Disease; Animals; Brain Chemistry; Choline; Choline O-Acetyltransferase; Cognition; Forecasting; Humans; Memory; Memory Disorders; Mice; Models, Neurological; Parasympathetic Nervous System; Parasympathomimetics; Phosphatidylcholines; Rats; Receptors, Muscarinic | 1982 |
The effect of tacrine and lecithin in Alzheimer's disease. A population pharmacodynamic analysis of five clinical trials.
Topics: Alzheimer Disease; Cognition; Disease Progression; Drug Therapy, Combination; Humans; Phosphatidylcholines; Tacrine | 1994 |
What have we learned from the THA trials to facilitate testing of new AChE inhibitors.
Topics: Alzheimer Disease; Chemical and Drug Induced Liver Injury; Cholinesterase Inhibitors; Clinical Trials as Topic; Double-Blind Method; Gastrointestinal Diseases; Humans; Phosphatidylcholines; Psychological Tests; Research Design; Tacrine; Treatment Outcome | 1993 |
Tacrine treatment of Alzheimer's disease: many expectations, few certainties.
Topics: Aged; Alzheimer Disease; Clinical Trials as Topic; Female; Humans; Male; Middle Aged; Nootropic Agents; Odds Ratio; Phosphatidylcholines; Quality of Life; Randomized Controlled Trials as Topic; Tacrine | 1998 |
Lecithin for dementia and cognitive impairment.
Topics: Alzheimer Disease; Cognition Disorders; Dementia; Humans; Phosphatidylcholines | 2000 |
Lecithin for dementia and cognitive impairment.
Topics: Alzheimer Disease; Cognition Disorders; Dementia; Humans; Phosphatidylcholines; Randomized Controlled Trials as Topic | 2000 |
Can drugs improve memory?
Topics: Acetylcholine; Alzheimer Disease; Animals; Choline; Cholinesterase Inhibitors; Humans; Memory; Parasympathetic Nervous System; Parasympatholytics; Parasympathomimetics; Phosphatidylcholines; Scopolamine | 1979 |
Alternatives in the treatment of memory loss in patients with Alzheimer's disease.
Topics: Alzheimer Disease; Humans; Memory Disorders; Multicenter Studies as Topic; Phosphatidylcholines; Physostigmine; Tacrine | 1991 |
Alzheimer's disease and THA: a review of the cholinergic theory and of preliminary results.
Topics: Aging; Alzheimer Disease; Aminoacridines; Clinical Trials as Topic; Cognition; Double-Blind Method; Humans; Multicenter Studies as Topic; Phosphatidylcholines; Tacrine | 1989 |
Biochemistry of Alzheimer's disease: a report.
Topics: Acetylcholine; Acetylcholinesterase; Alzheimer Disease; Animals; Brain Chemistry; Cats; Choline; Humans; Membranes; Nerve Tissue Proteins; Phosphatidylcholines; Receptors, Muscarinic; Somatostatin; Synapses | 1985 |
[Recent drug therapy of senile dementia].
Topics: Adrenocorticotropic Hormone; Alzheimer Disease; Choline; Dementia; Dihydroergotoxine; Humans; Narcotic Antagonists; Peptide Fragments; Phosphatidylcholines; Physostigmine; Piracetam; Pyrrolidines; Succinimides | 1987 |
Phosphatidylcholine, choline and cholinergic function.
Topics: Acetyl Coenzyme A; Acetylcholine; Aging; Alzheimer Disease; Animals; Avoidance Learning; Biological Transport; Blood-Brain Barrier; Brain; Choline; Choline O-Acetyltransferase; Cognition Disorders; Diet; Humans; Memory Disorders; Neurons; Phosphatidylcholines; Rats | 1986 |
Aspects of nutrition in the elderly.
Topics: Adipose Tissue; Adult; Aged; Aging; Alzheimer Disease; Anemia; Animals; Body Water; Cardiovascular Diseases; Cholesterol; Colonic Neoplasms; Diet; Diet Surveys; Energy Metabolism; Female; Humans; Male; Middle Aged; Muscle Proteins; Nutrition Disorders; Nutritional Physiological Phenomena; Nutritional Requirements; Osteoporosis; Phosphatidylcholines; Proteins; Rats; United Kingdom; United States; Vitamins | 1985 |
35 trial(s) available for phosphatidylcholines and Alzheimer Disease
| Article | Year |
|---|---|
Hearing Loss in Alzheimer's Disease Is Associated with Altered Serum Lipidomic Biomarker Profiles.
Topics: Aged; Aging; Alzheimer Disease; Antioxidants; Biomarkers; Female; Hearing Loss; Humans; Lipidomics; Lipids; Male; Phosphatidylcholines; Phosphatidylethanolamines | 2020 |
Plasma phosphatidylcholine docosahexaenoic acid content and risk of dementia and Alzheimer disease: the Framingham Heart Study.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Dementia; Docosahexaenoic Acids; Female; Follow-Up Studies; Humans; Incidence; Male; Mental Status Schedule; Phosphatidylcholines; Proportional Hazards Models; Prospective Studies; Risk | 2006 |
Lecithin in Alzheimer's disease.
Topics: Alzheimer Disease; Clinical Trials as Topic; Dementia; Humans; Phosphatidylcholines | 1982 |
Early results from double-blind, placebo controlled trial of high dose phosphatidylcholine in Alzheimer's disease.
Topics: Aged; Alzheimer Disease; Clinical Trials as Topic; Dementia; Double-Blind Method; Humans; Middle Aged; Phosphatidylcholines | 1983 |
Memory enhancement with oral physostigmine in Alzheimer's disease.
Topics: Aged; Alzheimer Disease; Clinical Trials as Topic; Dementia; Double-Blind Method; Female; Humans; Male; Memory; Middle Aged; Phosphatidylcholines; Physostigmine | 1983 |
Oral physostigmine and lecithin improve memory in Alzheimer disease.
Topics: Aged; Alzheimer Disease; Clinical Trials as Topic; Dementia; Double-Blind Method; Drug Therapy, Combination; Humans; Memory Disorders; Middle Aged; Phosphatidylcholines; Physostigmine | 1983 |
Lecithin in the treatment of Alzheimer's disease.
Topics: Alzheimer Disease; Clinical Trials as Topic; Dementia; Double-Blind Method; Humans; Middle Aged; Phosphatidylcholines | 1983 |
Comparison of therapeutic response to long-term treatment with lecithin versus piracetam plus lecithin in patients with Alzheimer's disease.
Topics: Aged; Alzheimer Disease; Double-Blind Method; Drug Therapy, Combination; Humans; Long-Term Care; Middle Aged; Phosphatidylcholines; Piracetam; Pyrrolidinones | 1984 |
Lecithin administration in Alzheimer dementia.
Topics: Aged; Alzheimer Disease; Dementia; Double-Blind Method; Female; Humans; Male; Middle Aged; Phosphatidylcholines | 1982 |
Double blind study of lecithin in patients with Alzheimer's disease.
Topics: Aged; Alzheimer Disease; Choline; Clinical Trials as Topic; Dementia; Double-Blind Method; Female; Humans; Male; Middle Aged; Phosphatidylcholines | 1981 |
Fluctuations of free choline levels in plasma of Alzheimer patients receiving lecithin: preliminary observations.
Topics: Aged; Alzheimer Disease; Choline; Clinical Trials as Topic; Dementia; Double-Blind Method; Humans; Middle Aged; Patient Compliance; Phosphatidylcholines | 1982 |
A dose-ranging study of lecithin in the treatment of primary degenerative dementia (Alzheimer disease).
Topics: Aged; Alzheimer Disease; Choline; Dementia; Double-Blind Method; Drug Evaluation; Erythrocytes; Female; Humans; Male; Memory; Phosphatidylcholines | 1982 |
Alzheimer disease: lack of effect of lecithin treatment for 3 months.
Topics: Aged; Alzheimer Disease; Choline; Dementia; Double-Blind Method; Humans; Middle Aged; Phosphatidylcholines; Psychological Tests; Time Factors | 1981 |
Efficacy of tacrine and lecithin in mild to moderate Alzheimer's disease: double blind trial.
Topics: Activities of Daily Living; Affect; Aged; Aged, 80 and over; Alzheimer Disease; Double-Blind Method; Female; Humans; Male; Memory; Middle Aged; Neuropsychological Tests; Phosphatidylcholines; Tacrine; Treatment Outcome | 1994 |
Delayed matching-to-sample performance during a double-blind trial of tacrine (THA) and lecithin in patients with Alzheimer's disease.
Topics: Aged; Alzheimer Disease; Analysis of Variance; Cognition; Double-Blind Method; Humans; Male; Phosphatidylcholines; Psychomotor Performance; Tacrine | 1993 |
Effects of physostigmine and lecithin on memory in Alzheimer disease.
Topics: Aged; Alzheimer Disease; Dementia; Double-Blind Method; Female; Humans; Male; Memory; Middle Aged; Phosphatidylcholines; Physostigmine | 1979 |
SPECT brain imaging in Alzheimer's disease during treatment with oral tetrahydroaminoacridine and lecithin.
Topics: Administration, Oral; Aged; Aged, 80 and over; Alzheimer Disease; Amphetamines; Brain; Cerebrovascular Circulation; Double-Blind Method; Humans; Iodine Radioisotopes; Iofetamine; Middle Aged; Phosphatidylcholines; Tacrine; Tomography, Emission-Computed, Single-Photon | 1992 |
The effect of long-term high dose lecithin on erythrocyte choline transport in Alzheimer patients.
Topics: Aged; Alzheimer Disease; Choline; Dose-Response Relationship, Drug; Erythrocytes; Female; Humans; Long-Term Care; Male; Phosphatidylcholines | 1992 |
Tacrine in Alzheimer's disease.
Topics: Activities of Daily Living; Adult; Aged; Aged, 80 and over; Alzheimer Disease; Aptitude Tests; Double-Blind Method; Drug Administration Schedule; Drug Evaluation; Drug Therapy, Combination; Female; Humans; Intelligence; Intelligence Tests; Liver Function Tests; Male; Middle Aged; Phosphatidylcholines; Pilot Projects; Severity of Illness Index; Tacrine | 1991 |
Tetrahydroaminoacridine and lecithin in the treatment of Alzheimer's disease. Effect on cognition, functioning in daily life, behavioural disturbances and burden experienced by the carers.
Topics: Aged; Alzheimer Disease; Behavior; Cognition; Female; Humans; Male; Middle Aged; Phosphatidylcholines; Psychological Tests; Quality of Life; Tacrine | 1991 |
Alternatives in the treatment of memory loss in patients with Alzheimer's disease.
Topics: Alzheimer Disease; Humans; Memory Disorders; Multicenter Studies as Topic; Phosphatidylcholines; Physostigmine; Tacrine | 1991 |
Tacrine (tetrahydroaminoacridine; THA) and lecithin in senile dementia of the Alzheimer type: a multicentre trial. Groupe Français d'Etude de la Tetrahydroaminoacridine.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Aminoacridines; Behavior; Chemical and Drug Induced Liver Injury; Cognition; Double-Blind Method; Drug Therapy, Combination; Female; Follow-Up Studies; Humans; Male; Middle Aged; Multicenter Studies as Topic; Phosphatidylcholines; Psychological Tests; Randomized Controlled Trials as Topic; Tacrine | 1990 |
Tetrahydroaminoacridine-lecithin combination treatment in patients with intermediate-stage Alzheimer's disease. Results of a Canadian double-blind, crossover, multicenter study.
Topics: Administration, Oral; Aged; Aged, 80 and over; Alzheimer Disease; Aminoacridines; Cholinesterase Inhibitors; Double-Blind Method; Drug Evaluation; Drug Therapy, Combination; Drug Tolerance; Female; Humans; Intelligence Tests; Male; Middle Aged; Multicenter Studies as Topic; Patient Compliance; Phosphatidylcholines; Randomized Controlled Trials as Topic; Tacrine | 1990 |
Treatment of Alzheimer's disease with short- and long-term oral THA and lecithin: a double-blind study.
Topics: Aged; Alzheimer Disease; Aminoacridines; Clinical Trials as Topic; Double-Blind Method; Drug Therapy, Combination; Humans; Male; Phosphatidylcholines; Tacrine | 1990 |
Early stages of late onset Alzheimer's disease. Diagnostic criteria, protein metabolism, precursor loading effects, neurochemical and neuropsychological applications.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Brain; Choline; Clinical Trials as Topic; Double-Blind Method; Female; Humans; Levodopa; Male; Nerve Tissue Proteins; Neuropsychological Tests; Neurotransmitter Agents; Phosphatidylcholines; Tryptophan | 1989 |
Canadian collaborative study of tetrahydroaminoacridine (THA) and lecithin treatment of Alzheimer's disease: effect on mood.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Aminoacridines; Clinical Trials as Topic; Depressive Disorder; Female; Follow-Up Studies; Humans; Male; Middle Aged; Neuropsychological Tests; Phosphatidylcholines; Tacrine | 1989 |
Progress report on the Canadian Multicentre Trial of tetrahydroaminoacridine with lecithin in Alzheimer's disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Aminoacridines; Canada; Clinical Trials as Topic; Drug Combinations; Female; Humans; Male; Middle Aged; Multicenter Studies as Topic; Phosphatidylcholines; Tacrine | 1989 |
Alzheimer's disease and THA: a review of the cholinergic theory and of preliminary results.
Topics: Aging; Alzheimer Disease; Aminoacridines; Clinical Trials as Topic; Cognition; Double-Blind Method; Humans; Multicenter Studies as Topic; Phosphatidylcholines; Tacrine | 1989 |
Cholinergic effects on constructional abilities and on mnemonic processes: a case report.
Topics: Alzheimer Disease; Clinical Trials as Topic; Double-Blind Method; Female; Humans; Memory; Mental Recall; Middle Aged; Phosphatidylcholines; Physostigmine; Psychological Tests; Psychomotor Performance; Retention, Psychology | 1987 |
Failure of long term high-dose lecithin to retard progression of early-onset Alzheimer's disease.
Topics: Alzheimer Disease; Cognition; Double-Blind Method; Humans; Middle Aged; Phosphatidylcholines | 1987 |
Lecithin: absence of neurophysiologic effect in Alzheimer's disease by EEG topography.
Topics: Aged; Alzheimer Disease; Brain; Brain Mapping; Electroencephalography; Electrophysiology; Female; Humans; Male; Middle Aged; Phosphatidylcholines | 1987 |
Combination therapy with lecithin and ergoloid mesylates for Alzheimer's disease.
Topics: Aged; Alzheimer Disease; Ambulatory Care; Dihydroergotoxine; Double-Blind Method; Drug Therapy, Combination; Humans; Middle Aged; Phosphatidylcholines; Psychiatric Status Rating Scales; Psychological Tests | 1986 |
Clinical evaluation of compounds for the treatment of memory dysfunction.
Topics: Aged; Alzheimer Disease; Clinical Trials as Topic; Dose-Response Relationship, Drug; Drug Therapy, Combination; Female; Humans; Male; Middle Aged; Neuropsychological Tests; Phosphatidylcholines; Piracetam; Pyrrolidinones | 1985 |
Piracetam plus lecithin trials in senile dementia of the Alzheimer type.
Topics: Aged; Alzheimer Disease; Clinical Trials as Topic; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Male; Mental Recall; Phosphatidylcholines; Piracetam; Pyrrolidinones | 1985 |
A double-blind, placebo controlled trial of high-dose lecithin in Alzheimer's disease.
Topics: Aged; Alzheimer Disease; Choline; Clinical Trials as Topic; Dose-Response Relationship, Drug; Double-Blind Method; Female; Humans; Male; Neuropsychological Tests; Patient Compliance; Phosphatidylcholines | 1985 |
110 other study(ies) available for phosphatidylcholines and Alzheimer Disease
| Article | Year |
|---|---|
Anchoring of Amyloid-β onto Polyunsaturated Phospholipid Membranes.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Humans; Lipid Bilayers; Peptide Fragments; Phosphatidylcholines; Phospholipids; Phosphorylcholine | 2023 |
An Association Between Saturated Fatty Acid-Containing Phosphatidylcholine in Cerebrospinal Fluid with Tau Phosphorylation.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Biomarkers; Fatty Acids; Female; Humans; Peptide Fragments; Phosphatidylcholines; Phosphorylation; Sphingomyelins; tau Proteins | 2022 |
Decreases of ethanolamine plasmalogen and phosphatidylcholine in erythrocyte are a common phenomenon in Alzheimer's, Parkinson's, and coronary artery diseases.
Topics: Alzheimer Disease; Coronary Artery Disease; Erythrocyte Membrane; Humans; Parkinson Disease; Phosphatidylcholines; Phosphatidylethanolamines; Plasmalogens; Sphingomyelins | 2022 |
Lipids uniquely alter the secondary structure and toxicity of amyloid beta 1-42 aggregates.
Topics: Alzheimer Disease; Amyloid; Amyloid beta-Peptides; Humans; Peptide Fragments; Phosphatidylcholines; Protein Conformation, beta-Strand; Protein Structure, Secondary | 2023 |
Accelerated Breakdown of Phosphatidylcholine and Phosphatidylethanolamine Is a Predominant Brain Metabolic Defect in Alzheimer's Disease.
Topics: Alzheimer Disease; Brain; Humans; Phosphatidylcholines; Phosphatidylethanolamines; Phospholipids | 2023 |
Eicosapentaenoic Acid-Enriched Phosphatidylcholine Mitigated Aβ1-42-Induced Neurotoxicity via Autophagy-Inflammasome Pathway.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Autophagy; Eicosapentaenoic Acid; Hippocampus; Humans; Inflammasomes; Male; Memory; Phosphatidylcholines; Rats; Rats, Sprague-Dawley | 2019 |
Recovery of brain DHA-containing phosphatidylserine and ethanolamine plasmalogen after dietary DHA-enriched phosphatidylcholine and phosphatidylserine in SAMP8 mice fed with high-fat diet.
Topics: Alzheimer Disease; Animals; Cerebral Cortex; Diet, High-Fat; Disease Models, Animal; Docosahexaenoic Acids; Lipidomics; Male; Mice; Phosphatidylcholines; Phosphatidylserines; Plasmalogens | 2020 |
Brain region-specific lipid alterations in the PLB4 hBACE1 knock-in mouse model of Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid Precursor Protein Secretases; Animals; Aspartic Acid Endopeptidases; Diabetes Mellitus, Experimental; Diglycerides; Disease Models, Animal; Fatty Acids; Female; Gene Expression; Gene Knock-In Techniques; Hippocampus; Humans; Hypothalamus; Lipid Metabolism; Lipidomics; Male; Mice, Inbred C57BL; Mice, Transgenic; Organ Specificity; Phosphatidylcholines; Phosphatidylinositols; Sterols; Transgenes | 2020 |
A comparison of the location in membranes of curcumin and curcumin-derived bivalent compounds with potential neuroprotective capacity for Alzheimer's disease.
Topics: Alzheimer Disease; Curcumin; Humans; Hydrophobic and Hydrophilic Interactions; Lipid Bilayers; Magnetic Resonance Spectroscopy; Phosphatidylcholines; Water | 2021 |
Effect of Amyloid-β Monomers on Lipid Membrane Mechanical Parameters-Potential Implications for Mechanically Driven Neurodegeneration in Alzheimer's Disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Brain; Cell Membrane; Humans; Lipid Bilayers; Membrane Lipids; Membrane Potentials; Microscopy, Confocal; Molecular Dynamics Simulation; Neurodegenerative Diseases; Neurons; Peptide Fragments; Phosphatidylcholines | 2020 |
Effects of Dietary Supplementation with EPA-enriched Phosphatidylcholine and Phosphatidylethanolamine on Glycerophospholipid Profile in Cerebral Cortex of SAMP8 Mice fed with High-fat Diet.
Topics: Alzheimer Disease; Animals; Arachidonic Acid; Cerebral Cortex; Diet, High-Fat; Dietary Supplements; Disease Models, Animal; Eicosapentaenoic Acid; Fatty Acids, Unsaturated; Glycerophospholipids; Homeostasis; Lipid Metabolism; Lysophospholipids; Male; Mice; Phosphatidylcholines; Phosphatidylethanolamines; Phosphatidylserines; Plasmalogens | 2021 |
Plasma phosphatidylcholines and vitamin B12/folate levels are possible prognostic biomarkers for progression of Alzheimer's disease.
Topics: Alzheimer Disease; Biomarkers; Cognitive Dysfunction; Disease Progression; Folic Acid; Humans; Phosphatidylcholines; Prognosis; Vitamin B 12; Vitamins | 2021 |
Effects of the Hydrophilic N-Terminal Region on Aβ-Mediated Membrane Disruption.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Humans; Peptide Fragments; Phosphatidylcholines; Static Electricity | 2021 |
Potential Anti-Alzheimer Agents from Guanidinyl Tryptophan Derivatives with Activities of Membrane Adhesion and Conformational Transition Inhibitions.
Topics: Adhesiveness; Adsorption; Alzheimer Disease; Amyloid beta-Peptides; Cell Membrane; Guanidine; Humans; Ligands; Lipid Bilayers; Lipids; Models, Molecular; Molecular Dynamics Simulation; Phosphatidylcholines; Protein Conformation; Protein Structure, Secondary; Tryptophan; Water | 2021 |
Metabolic network failures in Alzheimer's disease: A biochemical road map.
Topics: Aged; Aged, 80 and over; Aging; Alzheimer Disease; Amino Acids; Amyloid beta-Peptides; Aniline Compounds; Cognitive Dysfunction; Cohort Studies; Cross-Sectional Studies; Fasting; Female; Humans; Male; Metabolic Diseases; Metabolic Networks and Pathways; Metabolomics; Peptide Fragments; Phosphatidylcholines; Sphingomyelins; tau Proteins; Thiazoles | 2017 |
Lysophosphatidylcholine export by human ABCA7.
Topics: Alzheimer Disease; Animals; Apolipoprotein A-I; Apolipoproteins E; ATP Binding Cassette Transporter 1; ATP-Binding Cassette Transporters; Biological Transport; Cell Line; Cholesterol; Cricetinae; HEK293 Cells; Humans; Lipid Metabolism; Lysophosphatidylcholines; Phosphatidylcholines; Phosphatidylethanolamines; Phospholipids; Sphingomyelins | 2017 |
Lipid membranes catalyse the fibril formation of the amyloid-β (1-42) peptide through lipid-fibril interactions that reinforce secondary pathways.
Topics: Alzheimer Disease; Amyloid; Amyloid beta-Peptides; Brain; Catalysis; Cell Membrane; Humans; Kinetics; Lipid Bilayers; Membrane Lipids; Peptide Fragments; Phosphatidylcholines | 2017 |
Model membrane size-dependent amyloidogenesis of Alzheimer's amyloid-β peptides.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Calorimetry; Circular Dichroism; Humans; Kinetics; Microscopy, Atomic Force; Peptide Fragments; Phosphatidylcholines; Unilamellar Liposomes | 2017 |
Comparative study of the effects of phosphatidylcholine rich in DHA and EPA on Alzheimer's disease and the possible mechanisms in CHO-APP/PS1 cells and SAMP8 mice.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Apoptosis; CHO Cells; Cognition; Cricetulus; Disease Models, Animal; Docosahexaenoic Acids; Eicosapentaenoic Acid; Humans; Male; Memory; Mice; Mice, Transgenic; Nerve Growth Factors; Oxidative Stress; Phosphatidylcholines; Presenilin-1 | 2018 |
Pramlintide: The Effects of a Single Drug Injection on Blood Phosphatidylcholine Profile for Alzheimer's Disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Amyloid beta-Peptides; Biomarkers; Cognitive Dysfunction; Female; Humans; Islet Amyloid Polypeptide; Logistic Models; Male; Middle Aged; Phosphatidylcholines; ROC Curve; tau Proteins | 2018 |
A comparative study of eicosapentaenoic acid enriched phosphatidylcholine and ethyl ester in improving cognitive deficiency in Alzheimer's disease model rats.
Topics: Alkylation; Alzheimer Disease; Animals; Apoptosis; Behavior, Animal; Cerebral Cortex; Dietary Supplements; Disease Models, Animal; Docosahexaenoic Acids; Eicosapentaenoic Acid; Glycogen Synthase Kinase 3 beta; Male; Maze Learning; Neurons; Nootropic Agents; Oxidative Stress; Phosphatidylcholines; Phosphorylation; Protein Processing, Post-Translational; Random Allocation; Rats, Sprague-Dawley; tau Proteins | 2018 |
Acyl-Alkyl-Phosphatidlycholines are Decreased in Saliva of Patients with Alzheimer's Disease as Identified by Targeted Metabolomics.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Biomarkers; Cognitive Dysfunction; Female; Humans; Male; Metabolomics; Phosphatidylcholines; Pilot Projects; Preliminary Data; Saliva; Sphingomyelins | 2019 |
High speed atomic force microscopy to investigate the interactions between toxic Aβ
Topics: Alzheimer Disease; Amyloid beta-Peptides; Cholesterol; G(M1) Ganglioside; Humans; Lipid Bilayers; Microscopy, Atomic Force; Peptide Fragments; Phosphatidylcholines | 2019 |
Longitudinal association between phosphatidylcholines, neuroimaging measures of Alzheimer's disease pathophysiology, and cognition in the Mayo Clinic Study of Aging.
Topics: Aged; Alzheimer Disease; Amyloidogenic Proteins; Cerebral Cortex; Cognition; Cross-Sectional Studies; Female; Glucose; Humans; Longitudinal Studies; Male; Middle Aged; Neuroimaging; Phosphatidylcholines | 2019 |
Molecular interactions of Alzheimer amyloid-β oligomers with neutral and negatively charged lipid bilayers.
Topics: Alzheimer Disease; Amino Acid Sequence; Amyloid beta-Peptides; Calcium; Humans; Lipid Bilayers; Molecular Dynamics Simulation; Molecular Sequence Data; Peptide Fragments; Phosphatidylcholines; Phosphatidylglycerols; Protein Structure, Secondary | 2013 |
AβP1-42 incorporation and channel formation in planar lipid membranes: the role of cholesterol and its oxidation products.
Topics: Alzheimer Disease; Amino Acid Sequence; Amyloid beta-Peptides; Blotting, Western; Cholesterol; Electrophoresis; Humans; Lipid Bilayers; Membrane Lipids; Molecular Sequence Data; Oxidation-Reduction; Peptide Fragments; Phosphatidylcholines | 2013 |
Different effects of Alzheimer's peptide Aβ(1-40) oligomers and fibrils on supported lipid membranes.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Cell Membrane; Humans; Lipid Bilayers; Microscopy, Atomic Force; Neurons; Peptide Fragments; Phosphatidylcholines; Phosphatidylserines | 2013 |
Familial Alzheimer's disease Osaka mutant (ΔE22) β-barrels suggest an explanation for the different Aβ1-40/42 preferred conformational states observed by experiment.
Topics: Alzheimer Disease; Amino Acid Sequence; Amyloid; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Binding Sites; Humans; Hydrophobic and Hydrophilic Interactions; Lipid Bilayers; Molecular Dynamics Simulation; Peptide Fragments; Phosphatidylcholines; Protein Conformation; Protein Structure, Secondary; Sequence Deletion | 2013 |
Evidence of altered phosphatidylcholine metabolism in Alzheimer's disease.
Topics: Alzheimer Disease; Apolipoproteins E; Chromatography, Liquid; Cognitive Dysfunction; Cohort Studies; Fatty Acids, Unsaturated; Female; Humans; Magnetic Resonance Spectroscopy; Male; Mass Spectrometry; Phosphatidylcholines; Predictive Value of Tests; ROC Curve | 2014 |
Plasma phospholipids identify antecedent memory impairment in older adults.
Topics: Aged; Alzheimer Disease; Asparagine; Biomarkers; Carnitine; Cognitive Dysfunction; Cohort Studies; Dipeptides; Female; Humans; Longitudinal Studies; Lysophosphatidylcholines; Malates; Male; Memory Disorders; Metabolome; Neuropsychological Tests; Phosphatidylcholines; Phosphatidylinositols; Phospholipids; Proline; Prospective Studies; Sensitivity and Specificity; Sphingomyelins; Ursodeoxycholic Acid | 2014 |
DHA-PC and PSD-95 decrease after loss of synaptophysin and before neuronal loss in patients with Alzheimer's disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Amyloid beta-Peptides; Autopsy; Brain Chemistry; Cell Death; Disease Progression; Disks Large Homolog 4 Protein; Docosahexaenoic Acids; Female; Gene Expression; Gray Matter; Humans; Intracellular Signaling Peptides and Proteins; Male; Membrane Proteins; Neurons; Phosphatidylcholines; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Synapses; Synaptophysin | 2014 |
Aggregation of Aß(25-35) on DOPC and DOPC/DHA bilayers: an atomic force microscopy study.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Cell Membrane; Docosahexaenoic Acids; Humans; Hydrophobic and Hydrophilic Interactions; Lipid Bilayers; Microscopy, Atomic Force; Phosphatidylcholines; Plaque, Amyloid | 2014 |
Modulation of Alzheimer's Aβ protofilament-membrane interactions by lipid headgroups.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Computer Simulation; Humans; Lipid Bilayers; Molecular Dynamics Simulation; Phosphatidylcholines; Phosphatidylethanolamines; Static Electricity; Statistics, Nonparametric; Structure-Activity Relationship | 2015 |
Age-dependent biochemical dysfunction in skeletal muscle of triple-transgenic mouse model of Alzheimer`s disease.
Topics: Acetylcholinesterase; Aging; Alzheimer Disease; Amyloid beta-Peptides; Animals; Arachidonic Acid; Catalase; Disease Models, Animal; Fatty Acids; Male; Mice, Inbred C57BL; Mice, Transgenic; Mitochondria; Mitochondrial Membranes; Muscle, Skeletal; Peptide Fragments; Phosphatidylcholines; Phosphatidylinositols; Phospholipases A2; Plasmalogens | 2015 |
Docosahexaenoic Acid-Phosphatidylcholine Improves Cognitive Deficits in an Aβ23-35-Induced Alzheimer's Disease Rat Model.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Cognition Disorders; Decapodiformes; Disease Models, Animal; Docosahexaenoic Acids; Female; Male; Peptide Fragments; Phosphatidylcholines; Rats; Rats, Wistar | 2016 |
Blood metabolite markers of cognitive performance and brain function in aging.
Topics: Aged; Aging; Alzheimer Disease; Biomarkers; Brain; Cerebrovascular Circulation; Cognition; Cognition Disorders; Female; Functional Neuroimaging; Humans; Longitudinal Studies; Male; Phosphatidylcholines; Positron-Emission Tomography | 2016 |
ABCA1-Mediated Cholesterol Efflux Capacity to Cerebrospinal Fluid Is Reduced in Patients With Mild Cognitive Impairment and Alzheimer's Disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Animals; ATP Binding Cassette Transporter 1; Biological Transport; Biomarkers; Case-Control Studies; Cell Line; Cholesterol; Cognitive Dysfunction; Cricetinae; Cross-Sectional Studies; Down-Regulation; Female; Humans; Male; Phosphatidylcholines; Transfection | 2016 |
Improved specificity of serum phosphatidylcholine detection based on side-chain losses during negative electrospray ionization tandem mass spectrometry.
Topics: Alzheimer Disease; Biomarkers; Case-Control Studies; Cognitive Dysfunction; Fatty Acids; Humans; Phosphatidylcholines; Sensitivity and Specificity; Spectrometry, Mass, Electrospray Ionization | 2016 |
Association between Plasma Ceramides and Phosphatidylcholines and Hippocampal Brain Volume in Late Onset Alzheimer's Disease.
Topics: Age Factors; Aged; Alzheimer Disease; Atrophy; Biomarkers; Ceramides; Cross-Sectional Studies; Female; Hippocampus; Humans; Magnetic Resonance Imaging; Male; Organ Size; Phosphatidylcholines | 2017 |
In vitro effects of the anti-Alzheimer drug memantine on the human erythrocyte membrane and molecular models.
Topics: Alzheimer Disease; Calorimetry, Differential Scanning; Dimyristoylphosphatidylcholine; Dose-Response Relationship, Drug; Erythrocyte Membrane; Erythrocytes; Humans; Lipid Bilayers; Lipids; Liposomes; Memantine; Microscopy, Electron, Scanning; Molecular Conformation; Phosphatidylcholines; Phosphatidylethanolamines; Thermodynamics; X-Ray Diffraction | 2017 |
Reduced Lipid Bilayer Thickness Regulates the Aggregation and Cytotoxicity of Amyloid-β.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Humans; Lipid Bilayers; Phosphatidylcholines; Protein Aggregates; Protein Structure, Secondary | 2017 |
Targeted Metabolomic Analysis of Soluble Lysates from Platelets of Patients with Mild Cognitive Impairment and Alzheimer's Disease Compared to Healthy Controls: Is PC aeC40:4 a Promising Diagnostic Tool?
Topics: Aged; Alzheimer Disease; Blood Platelets; Cognitive Dysfunction; Decision Trees; Female; Follow-Up Studies; Humans; Male; Mental Status and Dementia Tests; Metabolome; Metabolomics; Phosphatidylcholines; Single-Blind Method; Sphingomyelins | 2017 |
Cerebrospinal fluid secretory Ca2+-dependent phospholipase A2 activity is increased in Alzheimer disease.
Topics: Adult; Aged; Alzheimer Disease; Biomarkers; Calcium; Fluorescent Dyes; Humans; Middle Aged; Phosphatidylcholines; Phospholipases A2, Secretory; Reference Values; Young Adult | 2009 |
Amyloid-beta42 signals tau hyperphosphorylation and compromises neuronal viability by disrupting alkylacylglycerophosphocholine metabolism.
Topics: Aged; Alzheimer Disease; Amyloid beta-Peptides; Animals; Calpain; Caspases; Cell Survival; Cytoprotection; Endoplasmic Reticulum; Enzyme Activation; Epitopes; Glycogen Synthase Kinase 3; Humans; Intracellular Space; Mice; Mice, Transgenic; Neurons; Peptide Fragments; Phosphatidylcholines; Phospholipid Ethers; Phosphorylation; Protein Structure, Quaternary; Signal Transduction; Stress, Physiological; tau Proteins | 2009 |
Impact of phospholipid bilayer saturation on amyloid-beta protein aggregation intermediate growth: a quartz crystal microbalance analysis.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Fatty Acids; Lipid Bilayers; Liposomes; Peptide Fragments; Phenylenediamines; Phosphatidylcholines; Phospholipids; Quartz | 2010 |
Real-time observation of model membrane dynamics induced by Alzheimer's amyloid beta.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Peptide Fragments; Phosphatidylcholines; Unilamellar Liposomes | 2010 |
The binding affinity of anti-Aβ1-42 MAb-decorated nanoliposomes to Aβ1-42 peptides in vitro and to amyloid deposits in post-mortem tissue.
Topics: Alzheimer Disease; Amyloid; Amyloid beta-Peptides; Animals; Antibodies, Monoclonal; Antibody Affinity; Biotin; Brain; Humans; Liposomes; Mice; Mice, Inbred BALB C; Particle Size; Peptide Fragments; Phosphatidylcholines; Phosphatidylethanolamines; Plaque, Amyloid; Polyethylene Glycols; Staining and Labeling; Static Electricity; Surface Plasmon Resonance; Ultracentrifugation | 2011 |
Lipid composition influences the release of Alzheimer's amyloid β-peptide from membranes.
Topics: Alzheimer Disease; Amyloid beta-Peptides; G(M1) Ganglioside; Hydrogen Bonding; Membranes, Artificial; Molecular Dynamics Simulation; Phosphatidylcholines; Phosphatidylethanolamines; Phosphatidylserines | 2011 |
Surface chemistry of lipid raft and amyloid Aβ (1-40) Langmuir monolayer.
Topics: Adsorption; Alzheimer Disease; Amyloid beta-Peptides; Animals; Cattle; Chemistry, Physical; Cholesterol; Humans; Hydrogen-Ion Concentration; Liposomes; Membrane Microdomains; Peptide Fragments; Phosphatidylcholines; Phosphatidylglycerols; Plaque, Amyloid; Protein Structure, Secondary; Spectrum Analysis; Sphingolipids; Static Electricity; Surface Properties | 2011 |
A simple approach for human recombinant apolipoprotein E4 expression and purification.
Topics: Adenoviridae; Alzheimer Disease; Apolipoprotein E4; Astrocytoma; Cardiovascular Diseases; Cell Line, Tumor; Circular Dichroism; Cloning, Molecular; Electrophoresis, Polyacrylamide Gel; Escherichia coli; Gene Expression; Humans; Kinetics; Phosphatidylcholines; Plasmids; Protein Refolding; Protein Structure, Secondary; Recombinant Fusion Proteins; Thioredoxins; Transduction, Genetic; Transformation, Bacterial | 2011 |
From brain to food: analysis of phosphatidylcholins, lyso-phosphatidylcholins and phosphatidylcholin-plasmalogens derivates in Alzheimer's disease human post mortem brains and mice model via mass spectrometry.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Animals; Brain Chemistry; Case-Control Studies; Dietary Fats; Female; Humans; Lysophosphatidylcholines; Male; Mice; Middle Aged; Phosphatidylcholines; Plasmalogens; Tandem Mass Spectrometry | 2011 |
Differing modes of interaction between monomeric Aβ(1-40) peptides and model lipid membranes: an AFM study.
Topics: 1,2-Dipalmitoylphosphatidylcholine; Alzheimer Disease; Amyloid beta-Peptides; Cholesterol; Humans; Lipid Bilayers; Microscopy, Atomic Force; Peptide Fragments; Phosphatidylcholines | 2012 |
Ligustrazine phosphate ethosomes for treatment of Alzheimer's disease, in vitro and in animal model studies.
Topics: Acrylic Resins; Administration, Cutaneous; Alzheimer Disease; Amnesia; Animals; Antioxidants; Behavior, Animal; Brain; Chemistry, Pharmaceutical; Disease Models, Animal; Drug Carriers; Escape Reaction; Ethanol; Glutathione Peroxidase; Lipid Peroxidation; Male; Malondialdehyde; Memory; Mice; Mice, Inbred ICR; Mice, Nude; Microscopy, Confocal; Permeability; Phosphatidylcholines; Pyrazines; Rats; Rats, Sprague-Dawley; Reaction Time; Scopolamine; Skin; Skin Absorption; Superoxide Dismutase; Technology, Pharmaceutical; Time Factors | 2012 |
Binding of the three-repeat domain of tau to phospholipid membranes induces an aggregated-like state of the protein.
Topics: Alzheimer Disease; Amino Acid Sequence; Benzothiazoles; Biophysics; Circular Dichroism; Humans; Lipid Bilayers; Lipids; Liposomes; Lysine; Magnetic Resonance Spectroscopy; Methylation; Molecular Sequence Data; Phosphatidylcholines; Phosphatidylserines; Phospholipids; Protein Binding; Protein Conformation; Protein Structure, Secondary; Protein Structure, Tertiary; Static Electricity; tau Proteins; Thiazoles; Unilamellar Liposomes | 2012 |
How the amyloid-β peptide and membranes affect each other: an extensive simulation study.
Topics: 1,2-Dipalmitoylphosphatidylcholine; Algorithms; Alzheimer Disease; Amyloid beta-Peptides; Cell Membrane; Computer Simulation; Humans; Hydrogen-Ion Concentration; Ions; Lipid Bilayers; Lipids; Magnetic Resonance Spectroscopy; Peptides; Phosphatidylcholines; Phosphatidylglycerols; Protein Structure, Secondary; Temperature; Water | 2013 |
A cellular lipidomic study on the Aβ-induced neurotoxicity and neuroprotective effects of EGCG by using UPLC/MS-based glycerolipids profiling and multivariate analysis.
Topics: 1-Acylglycerophosphocholine O-Acyltransferase; Alzheimer Disease; Amyloid beta-Peptides; Animals; Arachidonic Acid; Catechin; Glycerides; Lipid Metabolism; Multivariate Analysis; Neurons; Neuroprotective Agents; PC12 Cells; Peptide Fragments; Phosphatidylcholines; Phospholipases A2; Phospholipids; Principal Component Analysis; Rats | 2012 |
Beta-amyloid 25 to 35 is intercalated in anionic and zwitterionic lipid membranes to different extents.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Anions; Biophysical Phenomena; Biophysics; Deuterium Oxide; Humans; Ions; Lipid Bilayers; Models, Statistical; Neutrons; Peptide Fragments; Peptides; Phosphatidylcholines | 2002 |
Formation of a membrane-active form of amyloid beta-protein in raft-like model membranes.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Cholesterol; G(M1) Ganglioside; Humans; Kinetics; Membrane Microdomains; Membranes, Artificial; Models, Biological; Models, Molecular; Phosphatidylcholines; Protein Structure, Secondary; Protein Transport; Spectrometry, Fluorescence; Sphingomyelins | 2003 |
The lowdown on Ginkgo biloba.
Topics: Acetylcarnitine; Acetylcholine; Alzheimer Disease; Animals; Antioxidants; Brain; Candy; Cognition; Dietary Sucrose; Dietary Supplements; Donepezil; Ginkgo biloba; Glucose; Humans; Indans; Memory; Neurotransmitter Agents; Phosphatidylcholines; Phosphatidylserines; Piperidines; Piracetam; Plant Extracts; Plant Preparations; Vinca Alkaloids | 2003 |
Decreased lysophosphatidylcholine/phosphatidylcholine ratio in cerebrospinal fluid in Alzheimer's disease.
Topics: alpha-Linolenic Acid; Alzheimer Disease; Amyloid beta-Peptides; Arachidonic Acid; Brain; Brain Chemistry; Cell Membrane; Choline; Down-Regulation; Female; Free Radicals; Humans; Lysophosphatidylcholines; Male; Neurons; Oxidative Stress; Phosphatidylcholines | 2003 |
FATTY ACID COMPOSITIONS OF HUMAN BRAIN LECITHIN AND SPHINGOMYELIN IN NORMAL INDIVIDUALS, SENILE CEREBRAL CORTICAL ATROPHY, ALZHEIMER'S DISEASE, METACHROMATIC LEUCODYSTROPHY, TAY-SACHS AND NIEMANN-PICK DISEASES.
Topics: Alzheimer Disease; Atrophy; Brain; Brain Chemistry; Brain Diseases; Cerebral Cortex; Chemistry Techniques, Analytical; Dementia; Diffuse Cerebral Sclerosis of Schilder; Fatty Acids; Humans; Lecithins; Leukodystrophy, Metachromatic; Lipidoses; Niemann-Pick Diseases; Phosphatidylcholines; Phospholipids; Psychotic Disorders; Sphingomyelins; Tay-Sachs Disease; Tuberous Sclerosis | 1965 |
Specificity and potential mechanism of sulfatide deficiency in Alzheimer's disease: an electrospray ionization mass spectrometric study.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Amyloid beta-Peptides; Animals; Brain; Brain Chemistry; Cells, Cultured; Fatty Acids; Galactosylceramides; Humans; Lewy Body Disease; Lipids; Lithium Compounds; Oligodendroglia; Parkinson Disease; Peptide Fragments; Phosphatidylcholines; Phosphatidylethanolamines; Phosphatidylglycerols; Phosphatidylinositols; Phosphatidylserines; Plasmalogens; Rats; Spectrometry, Mass, Electrospray Ionization; Sphingomyelins; Sulfoglycosphingolipids | 2003 |
Surface behavior and lipid interaction of Alzheimer beta-amyloid peptide 1-42: a membrane-disrupting peptide.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Biophysics; Cell Membrane; Cholesterol; Fluorescent Dyes; Humans; Ions; Kinetics; Lipid Bilayers; Lipids; Microscopy, Confocal; Oxidative Stress; Peptide Fragments; Peptides; Phosphatidylcholines; Pressure; Protein Binding; Sphingomyelins; Surface Properties; Temperature | 2005 |
Ion channel formation by Alzheimer's disease amyloid beta-peptide (Abeta40) in unilamellar liposomes is determined by anionic phospholipids.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Anions; Calcium; Humans; Hydrogen-Ion Concentration; Ion Channels; Liposomes; Peptide Fragments; Phosphatidylcholines; Phosphatidylinositols; Phosphatidylserines; Phospholipids; Sodium; Spectrometry, Fluorescence | 2006 |
Amyloid-beta peptide disruption of lipid membranes and the effect of metal ions.
Topics: Alzheimer Disease; Amino Acid Sequence; Amyloid beta-Peptides; Cations, Divalent; Circular Dichroism; Copper; Humans; Lipid Bilayers; Magnetic Resonance Spectroscopy; Membrane Lipids; Membrane Microdomains; Molecular Sequence Data; Peptide Fragments; Phosphatidylcholines; Phosphatidylserines; Spectrometry, Fluorescence; Zinc | 2006 |
A novel phospholipid derivative of indomethacin, DP-155 [mixture of 1-steroyl and 1-palmitoyl-2-{6-[1-(p-chlorobenzoyl)-5-methoxy-2-methyl-3-indolyl acetamido]hexanoyl}-sn-glycero-3-phosophatidyl [corrected] choline], shows superior safety and similar eff
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Area Under Curve; Brain; Brain Chemistry; Dinoprostone; Drug Combinations; Gastrointestinal Tract; Indomethacin; Kidney; Male; Mice; Mice, Transgenic; Peptide Fragments; Phosphatidylcholines; Rats; Rats, Sprague-Dawley | 2006 |
Paired helical filaments contain small amounts of cholesterol, phosphatidylcholine and sphingolipids.
Topics: Aged; Alzheimer Disease; Cholesterol; Chromatography, High Pressure Liquid; Electrophoresis, Polyacrylamide Gel; Female; Humans; Male; Microscopy, Electron; Neurofibrillary Tangles; Phosphatidylcholines; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Sphingolipids; tau Proteins | 2006 |
Phospholipase D1 is up-regulated in the mitochondrial fraction from the brains of Alzheimer's disease patients.
Topics: Aged; Alzheimer Disease; Brain; Female; Humans; Male; Mitochondria; Phosphatidic Acids; Phosphatidylcholines; Phosphatidylethanolamines; Phospholipase D; Protein Kinase C-alpha; Up-Regulation | 2006 |
Lithium and lecithin treatment in Alzheimer's disease: a pilot study.
Topics: Aged; Alzheimer Disease; Basal Ganglia Diseases; Cognition; Drug Therapy, Combination; Humans; Lithium; Lithium Carbonate; Male; Middle Aged; Phosphatidylcholines; Pilot Projects | 1984 |
Do raised brain aluminium levels in Alzheimer's dementia contribute to cholinergic neuronal deficits?
Topics: Aluminum; Alzheimer Disease; Animals; Biological Transport; Brain Chemistry; Choline; Choline O-Acetyltransferase; Humans; Parasympathetic Nervous System; Phosphatidylcholines; Rabbits | 1984 |
Plasma choline responses to lecithin-enriched soup.
Topics: Alzheimer Disease; Choline; Dyskinesia, Drug-Induced; Humans; Phosphatidylcholines | 1984 |
Oral physostigmine and lecithin improve memory in Alzheimer's disease.
Topics: Administration, Oral; Alzheimer Disease; Humans; Phosphatidylcholines; Physostigmine | 1983 |
Long-term administration of oral physostigmine and lecithin improve memory in Alzheimer's disease.
Topics: Administration, Oral; Alzheimer Disease; Humans; Memory Disorders; Phosphatidylcholines; Physostigmine | 1984 |
No effect from double-blind trial of physostigmine and lecithin in Alzheimer disease.
Topics: Aged; Alzheimer Disease; Clinical Trials as Topic; Dementia; Double-Blind Method; Female; Humans; Male; Memory; Middle Aged; Phosphatidylcholines; Physostigmine; Verbal Learning | 1983 |
Failure of single-dose lecithin to alter aspects of central cholinergic activity in Alzheimer's disease.
Topics: Aged; Alzheimer Disease; Blood Pressure; Choline; Dementia; Erythrocytes; Female; Humans; Hydrocortisone; Male; Memory; Middle Aged; Phosphatidylcholines; Prolactin; Pulse | 1983 |
Lecithin does not affect EEG spectral analysis or P300 in Alzheimer disease.
Topics: Aged; Alzheimer Disease; Choline; Dementia; Electroencephalography; Evoked Potentials; Female; Humans; Male; Middle Aged; Phosphatidylcholines; Spectrum Analysis | 1982 |
Cholinesterase enzymes in the blood of patients with Alzheimer's disease.
Topics: Aged; Alzheimer Disease; Butyrylcholinesterase; Cholinesterases; Dementia; Erythrocytes; Humans; Phosphatidylcholines; Plasma | 1982 |
Reduction of cholesterol risk factors by lecithin in patients with Alzheimer's disease.
Topics: Aged; Alzheimer Disease; Arteriosclerosis; Cholesterol; Dementia; Female; Humans; Lipoproteins, HDL; Lipoproteins, LDL; Male; Middle Aged; Phosphatidylcholines; Risk | 1982 |
The effects of lecithin on memory in patients with senile dementia of the Alzheimer's type [proceedings].
Topics: Alzheimer Disease; Cholesterol; Dementia; Humans; Learning; Memory; Phosphatidylcholines | 1981 |
Choline uptake in patients with Alzheimer pre-senile dementia.
Topics: Adolescent; Adult; Aged; Alzheimer Disease; Choline; Dementia; Erythrocytes; Female; Humans; Male; Middle Aged; Phosphatidylcholines; Sex Factors | 1981 |
Neurochemical approaches to the treatment of senile dementia.
Topics: Acetylcholine; Aged; Alzheimer Disease; Animals; Choline; Choline O-Acetyltransferase; Dementia; Dyskinesia, Drug-Induced; Female; Humans; Learning; Male; Memory; Middle Aged; Phosphatidylcholines; Physostigmine; Rats; Receptors, Cholinergic | 1980 |
Biochemical pathology and treatment strategies in Alzheimer's disease: emphasis on the cholinergic system.
Topics: Acetylcholine; Aged; Alzheimer Disease; Cerebral Cortex; Cholinesterase Inhibitors; Female; Humans; Male; Parasympathetic Nervous System; Parasympathomimetics; Phosphatidylcholines | 1993 |
An evaluation of the efficacy and safety of tetrahydroaminoacridine (THA) without lecithin in the treatment of Alzheimer's disease.
Topics: Activities of Daily Living; Aged; Aged, 80 and over; Alzheimer Disease; Chemical and Drug Induced Liver Injury; Female; Humans; Liver Function Tests; Male; Middle Aged; Neuropsychological Tests; Phosphatidylcholines; Quality of Life; Tacrine | 1993 |
Alzheimer's disease amyloid beta peptide 25-35 inhibits lipid peroxidation as a result of its membrane interactions.
Topics: Alzheimer Disease; Amino Acid Sequence; Amyloid beta-Peptides; Antioxidants; Humans; In Vitro Techniques; Lipid Bilayers; Lipid Peroxidation; Membrane Lipids; Molecular Structure; Peptide Fragments; Phosphatidylcholines | 1997 |
Regional membrane phospholipid alterations in Alzheimer's disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Arachidonic Acid; Brain; Docosahexaenoic Acids; Fatty Acids; Fatty Acids, Nonesterified; Female; Hippocampus; Humans; Male; Membrane Lipids; Oleic Acid; Phosphatidylcholines; Phosphatidylethanolamines; Phosphatidylinositols; Phospholipids; Stearic Acids | 1998 |
Membrane instability, plasmalogen content, and Alzheimer's disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Animals; Cell Membrane; Female; Humans; Lipid Bilayers; Male; Phosphatidylcholines; Phosphatidylethanolamines; Plasmalogens; Swine; Temperature; Temporal Lobe | 1998 |
Abnormal content of n-6 and n-3 long-chain unsaturated fatty acids in the phosphoglycerides and cholesterol esters of parahippocampal cortex from Alzheimer's disease patients and its relationship to acetyl CoA content.
Topics: Acetyl Coenzyme A; Aged; Aged, 80 and over; Alzheimer Disease; Cholesterol Esters; Chromatography, Gas; Fatty Acids; Fatty Acids, Omega-3; Fatty Acids, Omega-6; Fatty Acids, Unsaturated; Female; Glycerophosphates; Hippocampus; Humans; Male; Middle Aged; Phosphatidylcholines; Phosphatidylethanolamines; Phosphatidylinositols; Phosphatidylserines | 1998 |
Activity of phosphatidylethanolamine-N-methyltransferase in brain affected by Alzheimer's disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Brain; Enzyme Inhibitors; Frontal Lobe; Humans; Hydrogen-Ion Concentration; Kinetics; Methylation; Methyltransferases; Occipital Lobe; Octoxynol; Phosphatidylcholines; Phosphatidylethanolamine N-Methyltransferase; Phosphatidylethanolamines; Polysorbates | 1999 |
Decrease and structural modifications of phosphatidylethanolamine plasmalogen in the brain with Alzheimer disease.
Topics: Aged; Aged, 80 and over; Aldehydes; Alzheimer Disease; Brain; DNA; Fatty Acids; Female; Humans; Male; Middle Aged; Nerve Tissue Proteins; Phosphatidylcholines; Phosphatidylethanolamines; Phospholipids; Plasmalogens | 1999 |
Low serum docosahexaenoic acid is a significant risk factor for Alzheimer's dementia.
Topics: Aged; Alzheimer Disease; Biomarkers; Docosahexaenoic Acids; Humans; Longitudinal Studies; Phosphatidylcholines; Risk Assessment; Risk Factors; Time Factors | 1999 |
Acceleration of phosphatidylcholine synthesis and breakdown by inhibitors of mitochondrial function in neuronal cells: a model of the membrane defect of Alzheimer's disease.
Topics: Alzheimer Disease; Animals; Carbonyl Cyanide m-Chlorophenyl Hydrazone; Choline; Cytidine Diphosphate Choline; Dinitrophenols; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme Inhibitors; Glycerylphosphorylcholine; Membranes; Mitochondria; Neurons; PC12 Cells; Phosphatidylcholines; Phosphorylcholine; Rats; Sodium Azide; Time Factors; Uncoupling Agents | 2000 |
Fatty acid analysis of blood plasma of patients with Alzheimer's disease, other types of dementia, and cognitive impairment.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Brain; Case-Control Studies; Dementia; Docosahexaenoic Acids; Fatty Acids; Female; Humans; Lysophosphatidylcholines; Male; Neurobehavioral Manifestations; Phosphatidylcholines; Phosphatidylethanolamines; Phospholipids | 2000 |
Amyloid beta(1-42) and its beta(25-35) fragment induce in vitro phosphatidylcholine hydrolysis in bovine retina capillary pericytes.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Arachidonic Acid; Blood-Brain Barrier; Capillaries; Carbon Radioisotopes; Cattle; Cell Death; Cells, Cultured; Choline; Hydrolysis; Microscopy, Electron; Peptide Fragments; Pericytes; Phosphatidylcholines; Retinal Artery; Tritium | 2001 |
A novel action of alzheimer's amyloid beta-protein (Abeta): oligomeric Abeta promotes lipid release.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Astrocytes; Cells, Cultured; Centrifugation, Density Gradient; Cholesterol; Congo Red; Culture Media, Conditioned; Dose-Response Relationship, Drug; Enzyme Inhibitors; Free Radical Scavengers; Lipid Metabolism; Lipids; Macromolecular Substances; Microscopy, Electron; Neurons; Peptide Fragments; Phosphatidylcholines; Precipitin Tests; Protein Kinase C; Rats; Time Factors | 2001 |
A new role for apolipoprotein E: modulating transport of polyunsaturated phospholipid molecular species in synaptic plasma membranes.
Topics: Alzheimer Disease; Animals; Apolipoproteins E; Biological Transport; Cell Membrane; Docosahexaenoic Acids; Homeostasis; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Neurons; Phosphatidylcholines; Phosphatidylethanolamines; Phosphatidylserines; Synapses | 2002 |
Dietary lecithin supplements in dementia of Alzheimer type.
Topics: Acetylcholine; Alzheimer Disease; Dementia; Dietary Fats; Humans; Phosphatidylcholines | 1977 |
Lecithin in Alzheimer's disease.
Topics: Administration, Oral; Adult; Aged; Alzheimer Disease; Aptitude Tests; Dementia; Drug Evaluation; Female; Humans; Learning; Male; Memory; Middle Aged; Phosphatidylcholines | 1978 |
Drug combination may improve memory.
Topics: Alzheimer Disease; Dementia; Drug Therapy, Combination; Humans; Phosphatidylcholines; Physostigmine | 1979 |
Spouses' assessments of Alzheimer patients' response to THA and lecithin.
Topics: Alzheimer Disease; Attitude to Health; Caregivers; Drug Therapy, Combination; Female; Humans; Male; Phosphatidylcholines; Tacrine | 1992 |
Fatty acid composition of brain phospholipids in aging and in Alzheimer's disease.
Topics: Adult; Aged; Aged, 80 and over; Aging; Alzheimer Disease; Brain; Fatty Acids; Frontal Lobe; Hippocampus; Humans; Middle Aged; Phosphatidylcholines; Phosphatidylethanolamines; Phospholipids; Pons | 1991 |
Reflection of changes in membrane constituents in various regions of Alzheimer brains to differential scanning thermograms.
Topics: Aged; Alkaline Phosphatase; Alzheimer Disease; Brain; Brain Chemistry; Calorimetry, Differential Scanning; Cholesterol; Female; Humans; Lipids; Male; Membranes; Nerve Tissue Proteins; Phosphatidylcholines; Spectrophotometry, Ultraviolet; Triglycerides | 1990 |
Are drugs targeted at Alzheimer's disease useful? 1. Useful for what?
Topics: Aged; Alzheimer Disease; Drug Therapy, Combination; Humans; Phosphatidylcholines; Tacrine | 1990 |
Tetrahydroaminoacridine and lecithin for Alzheimer's disease.
Topics: Alzheimer Disease; Aminoacridines; Humans; Phosphatidylcholines; Research Design; Tacrine | 1990 |
Cerebral ageing, neurotransmitters and therapeutic implications.
Topics: Acetylcholine; Aged; Aging; Alzheimer Disease; Brain; Choline; Choline O-Acetyltransferase; Dihydroergotoxine; Humans; Memory Disorders; Neurotransmitter Agents; Phosphatidylcholines | 1985 |
Neurotransmitter precursors and brain function.
Topics: Aged; Aging; Alzheimer Disease; Animals; Biological Transport; Brain; Diet; Humans; Learning; Levodopa; Memory; Neurotransmitter Agents; Parkinson Disease; Phosphatidylcholines; Serotonin; Sleep; Tryptophan | 1986 |
[Cholinergic treatment strategies in Alzheimer's disease].
Topics: Acetylcholine; Alzheimer Disease; Brain; Choline; Cholinesterase Inhibitors; Drug Therapy, Combination; Humans; Mental Recall; Parasympathomimetics; Phosphatidylcholines; Piracetam; Receptors, Cholinergic; Receptors, Muscarinic | 1986 |
Lecithin and piracetam in Alzheimer's disease.
Topics: Aged; Alzheimer Disease; Drug Therapy, Combination; Female; Humans; Male; Middle Aged; Phosphatidylcholines; Piracetam; Pyrrolidinones | 1987 |
Acute and chronic effects of oral physostigmine and lecithin in Alzheimer's disease.
Topics: Administration, Oral; Alzheimer Disease; Dose-Response Relationship, Drug; Humans; Memory; Phosphatidylcholines; Physostigmine; Time Factors | 1986 |
Rational drug treatment of dementia?
Topics: Alzheimer Disease; Choline; Humans; Phosphatidylcholines | 1985 |
[Cerebrospinal fluid phospholipids in psychoses].
Topics: Alzheimer Disease; Bipolar Disorder; Dementia; Encephalitis; Humans; Influenza, Human; Intracranial Arteriosclerosis; Neurocognitive Disorders; Neurosyphilis; Phosphatidylcholines; Phosphatidylethanolamines; Phosphatidylinositols; Phosphatidylserines; Phospholipids; Rheumatic Diseases; Schizophrenia; Sphingomyelins | 1974 |