phorbols has been researched along with Skin Neoplasms in 122 studies
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 121 (99.18) | 18.7374 |
1990's | 0 (0.00) | 18.2507 |
2000's | 0 (0.00) | 29.6817 |
2010's | 1 (0.82) | 24.3611 |
2020's | 0 (0.00) | 2.80 |
Authors | Studies |
---|---|
Chen, L; Chen, RM; Han, J; Hong, L; Hu, WY; Liao, R; Sun, P; Xu, Z; Yoshizuka, N; Yu, G | 1 |
Astrup, EG; Elgjo, K; Iversen, OH | 1 |
Belman, S; Garte, SJ | 2 |
Reyes-Mayes, D; Volm, M; Wayss, K | 1 |
Indo, K; Miyaji, H | 1 |
Boutwell, RK; Perchellet, JP | 1 |
Schweizer, J; Winter, H | 1 |
Bhide, SV; Munir, KM; Rao, KV | 1 |
Pashko, LL; Rovito, RJ; Schwartz, AG; Sobel, EL; Williams, JR | 1 |
Ashendel, CL; Boutwell, RK; Takigawa, M; Verma, AK | 1 |
Ashendel, CL; Boutwell, RK; Verma, AK | 1 |
Kriegel, H; Schmahl, W; Senft, E | 1 |
Argyris, TS; Fürstenberger, G; Marks, F; Richter, H | 1 |
Boutwell, RK; Conrad, EA; Verma, AK | 1 |
Eisinger, M; Greenebaum, E; Nicolaides, M; Vogel, RH; Weinstein, IB | 1 |
Blumberg, PM; Delclos, KB; Dunn, JA; Jaken, S; Leach, KL; Yeh, E | 1 |
Mastro, AM | 1 |
Jetten, AM; Kawamura, H; Strickland, JE; Yuspa, SH | 1 |
Argyris, TS | 1 |
Kato, R; Nakadate, T; Sugimura, T; Yamamoto, S | 1 |
Goerttler, K; Hesse, B; Loehrke, H; Schweizer, J | 6 |
Klein-Szanto, AJ; Mamrack, MD; Reiners, JJ; Slaga, TJ | 1 |
Aizu, E; Kato, R; Nakadate, T; Yamamoto, S | 3 |
Fürstenberger, G; Goerttler, K; Kinzel, V; Loehrke, H; Marks, F | 1 |
Decina, PC; Diamond, L; DiGiovanni, J; Prichett, WP | 1 |
Fürstenberger, G; Marks, F | 1 |
Bhisey, RA; Borges, A; Ramchandani, AG; Sirsat, SM | 1 |
Forbes, PD; Sambuco, CP | 1 |
Chang, RL; Conney, AH; Huang, MT; Uskokovic, M; Wood, AW | 1 |
Fujiki, H; Inui, N; Iwata, K; Ohkawa, Y; Shibuya, H | 1 |
Bhisey, RA; Ramchandani, AG; Sirsat, SM | 1 |
Fischer, SM; Gleason, GL; Nelson, K; Slaga, TJ | 1 |
Berry, DL; Fürstenberger, G; Marks, F; Sorg, B | 1 |
Boutwell, RK; Simsiman, RC; Takigawa, M; Verma, AK | 1 |
Barrett, JC; Gray, T; Sisskin, EE | 1 |
Goerttler, K; Hecker, E; Hesse, B; Loehrke, H; Schweitzer, J; Seip, H | 1 |
Hosoda, Y; Iseki, H; Kato, R; Nakadate, T; Sonoda, S; Takemura, S; Ura, A; Yamamoto, S | 1 |
Fürstenberger, G; Marks, F; Sorg, B | 1 |
Bhisey, RA; Borges, A; Iyengar, B; Ramchandani, AG; Sirsat, SM | 1 |
Astrup, EG; Iversen, OH | 1 |
Chouroulinkov, I; Coulomb, H; Grover, PL; MacNicoll, AD; Sims, P | 1 |
Belman, S | 2 |
Fischer, SM; Hardin, LG; Slaga, TJ | 1 |
Shoyab, M; Todaro, GJ; Warren, TC | 1 |
Chambers, DA; Krueger, GG; Shelby, J | 1 |
Bhisey, RA; Iyengar, B; Sirsat, SM | 1 |
Hecker, E; Schmidt, R | 1 |
Iversen, OH; Iversen, UM | 2 |
Fischer, SM; Mills, GD; Slaga, TJ | 1 |
Fürstenberger, G; Ganss, M; Marks, F; Seemann, D | 1 |
Brynes, PJ; Hecker, E; Schmidt, R | 1 |
Boutwell, RK; Verma, AK | 3 |
Iversen, OH; Paulsen, JE; Schjølberg, A | 1 |
Blumberg, PM; Driedger, PE | 2 |
Bohrman, JS; Fischer, SM; Gleason, GL; Slaga, TJ | 1 |
Boutwell, RK; Mueller, GC; Slaga, TJ; Verma, AK; Wertz, PW | 1 |
Fischer, SM; Gleason, GL; Mills, GD; Slaga, TJ | 1 |
Martel, N; Saint-Vincent, L; Yamasaki, H | 1 |
Boutwell, RK; Verma, AK; Weekes, RG | 1 |
Melchionne, S; Segal, A; Seidman, I; Smith, AC; Tseng, SS; Van Duuren, BL | 1 |
Bracken, WM; Gleason, GL; Hennings, H; Slaga, TJ; Weeks, CE | 1 |
Armuth, V; Berenblum, I | 1 |
Balmain, A; Hecker, E | 1 |
Boutwell, RK; Mufson, RA; Simsiman, RC | 1 |
Abb, J; Bayliss, GJ; Deinhardt, F | 1 |
Bertsch, S; Fürstenberger, G; Marks, F | 1 |
Boutwell, RK; Fischer, SM; Gleason, GL; Mufson, RA; Slaga, TJ; Verma, AK | 1 |
Fusenig, NE; Murray, AW | 1 |
Marks, F; Schweizer, J | 1 |
Bresnick, E; Lamden, M; Meunier, P | 1 |
Boutwell, RK; Rice, HM; Shapas, BG; Verma, AK | 2 |
Melchionne, SM; Smith, AC; Van Duuren, BL | 1 |
Maté, U; Melchionne, S; Segal, A; Seidman, I; Smith, A; Solomon, JJ; Van Duuren, BL | 1 |
Segal, A; Van Duuren, BL | 1 |
Boutwell, RK | 1 |
Scribner, JD; Slaga, TJ; Viaje, A | 1 |
Goerttler, K; Loehrke, H | 2 |
Alonso, A; Balmain, A; Fischer, J | 1 |
Slaga, TJ; Viaje, A; Weinstein, IB; Wigler, M | 1 |
Ben, T; Colburn, N; Hennings, H; Kelsey, W; Lichti, U; Patterson, E; Slaga, TJ; Yuspa, SH | 1 |
Bhisey, RA; Sirsat, SM | 1 |
Colburn, NH; Head, R; Lau, S | 1 |
Roop, DR; Toftgard, R; Yuspa, SH | 1 |
Parkinson, EK | 1 |
Fürstenberger, G; Marks, F; Schweizer, J | 1 |
Iversen, OH | 1 |
Glasø, M; Hovig, T; Iversen, OH; Ree, K | 1 |
Fujiki, H | 1 |
McCormick, DL; Moon, RC | 1 |
Colburn, NH; Gindhart, TD; Nakamura, Y | 1 |
Adams, LM; Fischer, SM | 1 |
Fujiki, H; Iwashima, A; Konishi, S; Nishino, H; Okabe, H; Okamoto, H; Shibata, S; Sugimura, T; Takizawa, H; Yoshioka, K | 1 |
Hakaim, AG; Jacoby, WT; O'Connell, JF; Weiss, HS | 1 |
Kato, R; Nakadate, T; Yamamoto, S | 1 |
Fürstenberger, G; Kinzel, V; Loehrke, H; Marks, F | 1 |
Gragtmans, NJ; Jevcak, JJ; Mitchel, RE; Morrison, DP | 1 |
Bowden, GT; Jaffe, DR | 1 |
Creasia, D; Kripke, ML; Strickland, PT | 1 |
Diwan, BA; Henneman, J; Ward, JM; Wenk, ML | 1 |
Agrawal, HP; Randerath, E; Randerath, K | 1 |
Boutwell, RK; Cleaveland, JS; Ordman, AB | 1 |
Autrup, H; Christensen, B; Skibshøj, I; Skouv, J | 1 |
Aldaz, CM; Conti, CJ; Gimenez, IB; Klein-Szanto, AJ; Slaga, TJ | 1 |
Marian, B; Mazzucco, K | 1 |
Fischer, SM; Hardin, L; Klein-Szanto, A; Slaga, TJ | 1 |
Loprinzi, CL; Verma, AK | 1 |
Kishore, GS; Perchellet, EM; Perchellet, JP | 1 |
5 review(s) available for phorbols and Skin Neoplasms
Article | Year |
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Observations on the mechanism of skin tumor promotion by phorbol esters.
Topics: Adenosylmethionine Decarboxylase; Animals; Caenorhabditis elegans Proteins; Carrier Proteins; Cell Division; Eflornithine; Mice; Ornithine; Ornithine Decarboxylase; Ornithine Decarboxylase Inhibitors; Phorbols; Polyamines; Protein Kinase C; Protein Kinases; Receptors, Drug; Receptors, Immunologic; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1983 |
Phorbol ester receptors and the in vitro effects of tumor promoters.
Topics: Animals; Caenorhabditis elegans Proteins; Carrier Proteins; Mice; Neoplasms, Experimental; Phorbol 12,13-Dibutyrate; Phorbol Esters; Phorbols; Protein Kinase C; Receptors, Cell Surface; Receptors, Drug; Skin Neoplasms; Structure-Activity Relationship | 1983 |
Phorbol ester tumor promoters and lymphocyte proliferation.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Caenorhabditis elegans Proteins; Carrier Proteins; Lymphocyte Activation; Lymphocytes; Mice; Phorbol Esters; Phorbols; Protein Kinase C; Receptors, Cell Surface; Receptors, Drug; Skin Neoplasms; Structure-Activity Relationship; Tetradecanoylphorbol Acetate | 1983 |
Multistage tumor promotion in skin.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Caenorhabditis elegans Proteins; Carrier Proteins; Cell Division; Humans; Mice; Phorbol Esters; Phorbols; Protein Kinase C; Receptors, Drug; Receptors, Immunologic; Skin; Skin Neoplasms; Structure-Activity Relationship; Tetradecanoylphorbol Acetate | 1983 |
Defective responses of transformed keratinocytes to terminal differentiation stimuli. Their role in epidermal tumour promotion by phorbol esters and by deep skin wounding.
Topics: Animals; Carcinogens; Cell Differentiation; Cell Transformation, Neoplastic; Epidermis; In Vitro Techniques; Keratins; Mice; Mitosis; Oncogenes; Papilloma; Peptides; Phenotype; Phorbols; Protein Kinase C; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate; Transforming Growth Factors | 1985 |
117 other study(ies) available for phorbols and Skin Neoplasms
Article | Year |
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A novel function of p38-regulated/activated kinase in endothelial cell migration and tumor angiogenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinogens; Carcinoma; Cell Movement; Cell Transformation, Neoplastic; Cytoskeleton; Disease Progression; Endothelial Cells; Focal Adhesion Protein-Tyrosine Kinases; Intracellular Signaling Peptides and Proteins; MAP Kinase Signaling System; Mice; Mice, 129 Strain; Mice, Inbred C57BL; Neovascularization, Pathologic; Papilloma; Phorbols; Protein Serine-Threonine Kinases; Skin Neoplasms; Vascular Endothelial Growth Factor Receptor-2 | 2012 |
The tumorigenic and carcinogenic effect of TPA (12-0-tetradecanoylphorbol-13-acetate) when applied to the skin of BALB/cA mice.
Topics: Animals; Carcinogens; Female; Male; Mice; Mice, Inbred BALB C; Phorbols; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate; Time Factors | 1980 |
Decreased beta-adrenergic responsiveness in mouse epidermal papillomas during tumor promotion with phorbol myristate acetate.
Topics: Adrenergic beta-Agonists; Animals; Cyclic AMP; Female; Isoproterenol; Mice; Papilloma; Phorbols; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1980 |
Chemical carcinogenesis by the two-stage protocol in the skin Mastomys natalensis (Muridae) using topical initiation with 7,12-dimethylbenz(a)anthracene and topical promotion with 12-0-tetradecanoylphorbol-13-acetate.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Benz(a)Anthracenes; Female; Keratoacanthoma; Male; Muridae; Neoplasms, Experimental; Phorbols; Skin Diseases; Skin Neoplasms; Tetradecanoylphorbol Acetate; Time Factors | 1981 |
Effect of tumor promote phorbol esters on the in vitro keratinization of rat epidermal cells in normal, premalignant and malignant stages.
Topics: Aneuploidy; Animals; Cell Differentiation; Cell Division; Cell Line; Diploidy; Embryo, Mammalian; Epidermal Cells; Epidermis; Keratins; Phorbol Esters; Phorbols; Precancerous Conditions; Rats; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1981 |
Effects of 3-isobutyl-1-methylxanthine and cyclic nucleotides on the biochemical processes linked to skin tumor promotion by 12-O-tetradecanoylphorbol-13-acetate.
Topics: 1-Methyl-3-isobutylxanthine; Administration, Topical; Animals; Cocarcinogenesis; Cyclic AMP; Cyclic GMP; DNA, Neoplasm; Dose-Response Relationship, Drug; Female; Mice; Neoplasms, Experimental; Ornithine Decarboxylase; Papilloma; Phorbols; Skin Neoplasms; Tetradecanoylphorbol Acetate; Theophylline | 1981 |
Changes in regional keratin polypeptide patterns during phorbol ester-mediated reversible and permanently sustained hyperplasia of mouse epidermis.
Topics: Animals; Back; Ear; Hyperplasia; Keratins; Mice; Neoplasms, Experimental; Phorbol Esters; Phorbols; Skin; Skin Neoplasms; Tail | 1982 |
Effect of hexachlorocyclohexane on diethylnitrosamine-induced hepatocarcinogenesis in rat and its failure to promote skin tumors on dimethylbenz[a]anthracene initiation in mouse.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Benz(a)Anthracenes; Diethylnitrosamine; Drug Interactions; Female; gamma-Glutamyltransferase; Hexachlorocyclohexane; Liver; Liver Neoplasms, Experimental; Nitrosamines; Phorbols; Rats; Rats, Inbred Strains; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1984 |
Dehydroepiandrosterone (DHEA) and 3 beta-methylandrost-5-en-17-one: inhibitors of 7,12-dimethylbenz[a]anthracene (DMBA)-initiated and 12-O-tetradecanoylphorbol-13-acetate (TPA)-promoted skin papilloma formation in mice.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Androstenes; Animals; Benz(a)Anthracenes; Dehydroepiandrosterone; Drug Administration Schedule; Drug Antagonism; Estradiol; Female; Mice; Papilloma; Phorbols; Rats; Skin Neoplasms; Tetradecanoylphorbol Acetate; Uterus | 1984 |
Inhibition by prostaglandin synthesis inhibitors of the induction of epidermal ornithine decarboxylase activity, the accumulation of prostaglandins, and tumor promotion caused by 12-O-tetradecanoylphorbol-13-acetate.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Animals; Carboxy-Lyases; Cyclooxygenase Inhibitors; Female; Indomethacin; Mice; Neoplasms, Experimental; Ornithine Decarboxylase; Phorbols; Prostaglandins; Prostaglandins E, Synthetic; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate; Tretinoin | 1980 |
Can prenatal X-irradiation in mice act as an initiator stimulus in a modified 2-stage Berenblum/Mottram experiment with postnatal promotion with phorbol ester TPA?
Topics: Adenoma; Animals; Carcinoma, Hepatocellular; Cocarcinogenesis; Female; Fetus; Leukemia; Liver Neoplasms; Lung Neoplasms; Maternal-Fetal Exchange; Mice; Ovarian Diseases; Phorbols; Pregnancy; Prostaglandins; Radiation, Ionizing; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate; X-Rays | 1980 |
Effects of the phorbol ester 4-O-methyl-12-O-tetradecanoylphorbol-13-acetate on mouse skin in vivo: evidence for its uselessness as a negative control compound in studies on the biological effects of phorbol ester tumor promoters.
Topics: Animals; Cell Division; Cocarcinogenesis; Cyclic AMP; Epidermis; Female; Growth Inhibitors; Indomethacin; Mice; Neoplasms, Experimental; Phorbol Esters; Phorbols; Skin Neoplasms; Structure-Activity Relationship | 1982 |
Phorbol myristate acetate uncouples the relationship between beta-adrenergic receptors and adenyl cyclase in mouse epidermis: a phenotypic trait in papillomas.
Topics: Adenylyl Cyclases; Animals; Cocarcinogenesis; Cyclic GMP; Enzyme Activation; Epidermis; Isoproterenol; Mice; Neoplasms, Experimental; Papilloma; Phorbols; Receptors, Adrenergic; Receptors, Adrenergic, beta; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1982 |
Differential effects of retinoic acid and 7,8-benzoflavone on the induction of mouse skin tumors by the complete carcinogenesis process and by the initiation-promotion regimen.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Benz(a)Anthracenes; Benzo(a)pyrene; Benzoflavones; Benzopyrenes; Dose-Response Relationship, Drug; Enzyme Induction; Female; Flavonoids; Injections, Intraperitoneal; Methylcholanthrene; Mice; Neoplasms, Experimental; Ornithine Decarboxylase; Papilloma; Phorbols; Skin Neoplasms; Tetradecanoylphorbol Acetate; Tretinoin | 1982 |
Binding of phorbol dibutyrate and epidermal growth factor to cultured human epidermal cells.
Topics: Caenorhabditis elegans Proteins; Carrier Proteins; Cell Line; Epidermal Growth Factor; ErbB Receptors; Humans; Melanoma; Phorbol 12,13-Dibutyrate; Phorbol Esters; Phorbols; Protein Kinase C; Receptors, Cell Surface; Receptors, Drug; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1983 |
Interaction of epidermal growth factor with basal and differentiating epidermal cells of mice resistant and sensitive to carcinogenesis.
Topics: Animals; Animals, Newborn; Calcium; Cell Differentiation; Cells, Cultured; Epidermal Growth Factor; ErbB Receptors; Kinetics; Mice; Mice, Inbred Strains; Phorbols; Receptors, Cell Surface; Skin; Skin Neoplasms; Skin Physiological Phenomena; Species Specificity; Tetradecanoylphorbol Acetate | 1984 |
Nature of the epidermal hyperplasia produced by mezerein, a weak tumor promoter, in initiated skin of mice.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinogens; Diterpenes; Female; Hyperplasia; Mice; Neoplasms, Experimental; Phorbol Esters; Phorbols; Skin; Skin Neoplasms; Terpenes; Tetradecanoylphorbol Acetate | 1983 |
Inhibition of 12-O-tetradecanoylphorbol-13-acetate-induced tumor promotion and ornithine decarboxylase activity by quercetin: possible involvement of lipoxygenase inhibition.
Topics: Animals; DNA; Epidermis; Female; Flavonoids; Lipoxygenase Inhibitors; Mice; Ornithine Decarboxylase Inhibitors; Papilloma; Phorbols; Quercetin; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1983 |
Skin tumor formation in the European hamster (Cricetus cricetus L.) after topical initiation with 7,12-dimethylbenz[a]anthracene (DMBA) and promotion with 12-O-tetradecanoylphorbol-13-acetate (TPA).
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Benz(a)Anthracenes; Cricetinae; Drug Synergism; Female; Male; Neoplasms; Phorbols; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1984 |
Alteration in the distribution of the epidermal protein filaggrin during two-stage chemical carcinogenesis in the SENCAR mouse skin.
Topics: Amino Acids; Animals; Epidermis; Female; Filaggrin Proteins; Fluorescent Antibody Technique; Immunodiffusion; Intermediate Filament Proteins; Male; Mice; Mice, Inbred Strains; Phorbols; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1984 |
Effects of flavonoids and antioxidants on 12-O-tetradecanoyl-phorbol-13-acetate-caused epidermal ornithine decarboxylase induction and tumor promotion in relation to lipoxygenase inhibition by these compounds.
Topics: Animals; Antioxidants; Enzyme Induction; Epidermis; Female; Flavonoids; Lipoxygenase Inhibitors; Mice; Mice, Inbred Strains; Ornithine Decarboxylase; Ornithine Decarboxylase Inhibitors; Phorbols; Skin Neoplasms; Tetradecanoylphorbol Acetate; Time Factors | 1984 |
Suppression of the first stage of phorbol 12-tetradecanoate 13-acetate-effected tumor promotion in mouse skin by nontoxic inhibition of DNA synthesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Cell Transformation, Neoplastic; DNA Replication; Female; Hydroxyurea; Mice; Mice, Inbred Strains; Phorbol Esters; Phorbols; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1984 |
DBA/2 mice are as sensitive as SENCAR mice to skin tumor promotion by 12-O-tetradecanoylphorbol-13-acetate.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinogens; DNA; Female; Methylnitronitrosoguanidine; Mice; Mice, Inbred DBA; Mice, Inbred Strains; Phorbols; Skin Neoplasms; Species Specificity; Tetradecanoylphorbol Acetate | 1984 |
Effect of 12-O-tetradecanoylphorbol-13-acetate on epithelial tumor induction in methylcholanthrene injected Swiss albino mice.
Topics: Animals; Drug Synergism; Female; Methylcholanthrene; Mice; Phorbols; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1983 |
Interactions of ultraviolet radiation, 12-O-tetradecanoyl-phorbol-13-acetate and retinoic acid in the skin of hairless mice.
Topics: Animals; Carcinogens; Cocarcinogenesis; Epidermis; Male; Mice; Mice, Hairless; Mitosis; Neoplasms, Radiation-Induced; Phorbols; Skin Neoplasms; Tetradecanoylphorbol Acetate; Tretinoin; Ultraviolet Rays | 1983 |
1 alpha, 25-Dihydroxyvitamin D3 inhibits phorbol ester-dependent chemical carcinogenesis in mouse skin.
Topics: Administration, Topical; Animals; Calcitriol; Female; Mice; Phorbols; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1983 |
A rapid, simple screening method for skin-tumor promoters using mouse peritoneal macrophages in vitro.
Topics: Animals; Carcinogens; Female; Macrophages; Mice; Mice, Inbred ICR; Nitroblue Tetrazolium; Phagocytosis; Phorbol Esters; Phorbols; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1984 |
Effects of 12-O-tetradecanoylphorbol-13-acetate on the incorporation of labelled precursors into RNA, DNA and protein in epidermis, dermis and subcutis from precancerous mouse skin with reference to enhanced tumorigenesis.
Topics: Animals; Carbon Radioisotopes; DNA Replication; Female; Kinetics; Leucine; Mice; Phorbols; Precancerous Conditions; Protein Biosynthesis; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate; Thymidine; Transcription, Genetic; Tritium; Uridine | 1984 |
Two-stage tumorigenesis of dermal melanocytes in the back skin of the Syrian golden hamster using systemic initiation with 7,12-dimethylbenz(a)anthracene and topical promotion with 12-O-tetradecanoylphorbol-13-acetate.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Benz(a)Anthracenes; Cocarcinogenesis; Cricetinae; Female; Melanocytes; Melanoma; Mesocricetus; Neoplasms, Experimental; Phorbols; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1980 |
Positive two-stage carcinogenesis in female Sprague-Dawley rats using 7,12-dimethylbenz(a)anthracene (dmba) as initiator and 12-o-tetradecanoylphorbol-13-acetate (tps) as promotor. Results of a pilot study.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Administration, Topical; Animals; Benz(a)Anthracenes; Castration; Cocarcinogenesis; Colonic Neoplasms; Female; Intestinal Neoplasms; Liver Neoplasms; Phorbols; Rats; Skin Neoplasms; Stomach; Stomach Neoplasms; Tetradecanoylphorbol Acetate | 1980 |
Studies on the mechanism of skin tumor promotion: evidence for several stages in promotion.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinogens; Chemical Phenomena; Chemistry; Cocarcinogenesis; Diterpenes; Dose-Response Relationship, Drug; Drug Synergism; Female; Mice; Neoplasms, Experimental; Phorbol Esters; Phorbols; Skin; Skin Neoplasms; Terpenes; Tetradecanoylphorbol Acetate | 1980 |
Two-stage skin carcinogenesis by systemic initiation of pregnant mice with 7,12-dimethylbenz(a)anthracene during gestation days 6-20 and postnatal promotion of the F 1-generation with the phorbol ester 12-tetradecanoylphorbol-13-acetate.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Benz(a)Anthracenes; Female; Fetus; Gestational Age; Mice; Phorbols; Pregnancy; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1980 |
Skin tumor promotion by phorbol esters is a two-stage process.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Cell Division; Diterpenes; Female; Mice; Mitogens; Neoplasms, Experimental; Phorbol Esters; Phorbols; Prostaglandins; Skin Neoplasms; Structure-Activity Relationship; Terpenes | 1981 |
Diterpene ester-mediated two-stage carcinogenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Cocarcinogenesis; Cricetinae; Female; Guinea Pigs; Male; Maternal-Fetal Exchange; Mice; Mice, Inbred Strains; Milk; Neoplasms, Experimental; Phorbols; Pregnancy; Prenatal Exposure Delayed Effects; Rabbits; Rats; Skin Neoplasms; Tetradecanoylphorbol Acetate; Vaginal Neoplasms | 1982 |
Polyamine biosynthesis and skin tumor promotion: inhibition of 12-O-tetradecanoylphorbol-13-acetate-promoted mouse skin tumor formation by the irreversible inhibitor of ornithine decarboxylase alpha-difluoromethylornithine.
Topics: Adenosylmethionine Decarboxylase; Animals; Carboxy-Lyases; Drug Antagonism; Eflornithine; Kinetics; Mice; Neoplasms, Experimental; Ornithine; Ornithine Decarboxylase Inhibitors; Phorbols; Polyamines; Putrescine; Skin; Skin Neoplasms; Spermidine; Spermine; Tetradecanoylphorbol Acetate | 1982 |
Correlation between sensitivity to tumor promotion and sustained epidermal hyperplasia of mice and rats treated with 12-O-tetra-decanoylphorbol-13-acetate.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Cell Division; Dose-Response Relationship, Drug; Hyperplasia; Methylnitronitrosoguanidine; Mice; Mice, Inbred Strains; Phorbols; Rats; Rats, Inbred F344; Skin; Skin Neoplasms; Species Specificity; Tetradecanoylphorbol Acetate | 1982 |
7,12-Dimethylbenz[a]anthracene/12-O-tetradecanoyl-phorbol-13-acetate-mediated skin tumor initiation and promotion in male Sprague-Dawley rats.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Benz(a)Anthracenes; Carcinogens; Cocarcinogenesis; Diazonium Compounds; Male; Neoplasms, Experimental; Phorbols; Rats; Rats, Inbred Strains; Skin Neoplasms; Tetradecanoylphorbol Acetate; Time Factors | 1982 |
Effect of the tumor promoter 12-O-tetradecanoylphorbol-13-acetate and its nonpromoting analogue 4-O-methyl-TPA on dorsal dermal melanocytes of the Syrian golden hamster (Mesocricetus auratus).
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Cricetinae; Female; Melanocytes; Melanoma; Mesocricetus; Phorbols; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1982 |
Inhibition of 12-O-tetradecanoyl-phorbol-13-acetate-induced tumor promotion by nordihydroguaiaretic acid, a lipoxygenase inhibitor, and p-bromophenacyl bromide, a phospholipase A2 inhibitor.
Topics: Acetophenones; Animals; Catechols; Enzyme Inhibitors; Female; Lipoxygenase Inhibitors; Masoprocol; Mice; Mice, Inbred Strains; Neoplasms, Experimental; Phorbols; Phospholipases; Phospholipases A; Phospholipases A2; Pyrazoles; Skin Neoplasms; Tetradecanoylphorbol Acetate; Time Factors | 1982 |
Tumor promotion by phorbol esters in skin: evidence for a memory effect.
Topics: Animals; Carcinogens; Cell Line; Epidermis; Female; Hyperplasia; Mice; Mice, Inbred Strains; Neoplasms, Experimental; Phorbol Esters; Phorbols; Precancerous Conditions; Skin Neoplasms; Tetradecanoylphorbol Acetate; Time Factors | 1983 |
12-0-Tetradecanoylphorbol-13-acetate-induced amplification of mesenchymal tumorigenesis in the mouse skin.
Topics: Animals; Cocarcinogenesis; Female; Methylcholanthrene; Mice; Mice, Inbred Strains; Phorbols; Sarcoma, Experimental; Skin Neoplasms; Tetradecanoylphorbol Acetate; Time Factors | 1983 |
The tumourigenic and carcinogenic effect of 12-0-tetradecanoylphorbol-13-acetate when applied to the skin of BALB/cA and hairless (hr/hr) mice.
Topics: Amyloidosis; Animals; Female; Kupffer Cells; Male; Mice; Mice, Hairless; Mice, Inbred BALB C; Papilloma; Phorbols; Skin Neoplasms; Tetradecanoylphorbol Acetate; Time Factors | 1983 |
Tumour-initiating activities of dihydrodiols of dibenz[a,c]anthracene.
Topics: Animals; Benz(a)Anthracenes; Female; Mice; Neoplasms, Experimental; Phorbols; Skin Neoplasms; Structure-Activity Relationship; Tetradecanoylphorbol Acetate | 1983 |
Onion and garlic oils inhibit tumor promotion.
Topics: Animals; Cell Transformation, Neoplastic; Drug Antagonism; Female; Garlic; Mice; Mice, Inbred Strains; Neoplasms, Experimental; Oils; Phorbols; Plants, Medicinal; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1983 |
Diazepam inhibition of phorbol ester tumor promotion.
Topics: Animals; Diazepam; Dose-Response Relationship, Drug; Female; Male; Mice; Papilloma; Phorbols; Sex Factors; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1983 |
Phorbol-12,13-diester 12-ester hydrolase may prevent tumour promotion by phorbol diesters in skin.
Topics: Animals; Carboxylic Ester Hydrolases; Cats; Child, Preschool; Cricetinae; Dogs; Female; Guinea Pigs; Humans; Kinetics; Macaca mulatta; Mice; Neoplasms, Experimental; Phorbol 12,13-Dibutyrate; Phorbol Esters; Phorbols; Rabbits; Rats; Skin Neoplasms; Species Specificity; Swine | 1982 |
Epidermal proliferation of nude mouse skin, pig skin, and pig skin grafts. Failure of nude mouse skin to respond to the tumor promoter 12-O-tetradecanoyl phorbol 13-acetate.
Topics: Animals; Mice; Mice, Nude; Neoplasms, Experimental; Phorbols; Skin; Skin Neoplasms; Skin Transplantation; Swine; Tetradecanoylphorbol Acetate; Transplantation Immunology; Transplantation, Heterologous | 1980 |
Effect of the active tumor promoter, 12-O-tetradecanoylphorbol-13-acetate on hair follicular growth and development of hair anlage tumors in the mouse skin: a comparison with human adnexal lesions.
Topics: Animals; Cocarcinogenesis; Epidermis; Female; Hair; Humans; Hyperplasia; Methylcholanthrene; Mice; Phorbols; Precancerous Conditions; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1982 |
Simple phorbol esters as inhibitors of tumor promotion by TPA in mouse skin.
Topics: Animals; Cocarcinogenesis; DNA; Dose-Response Relationship, Drug; Epidermis; Female; Hyperplasia; Mice; Neoplasms, Experimental; Phorbol Esters; Phorbols; Skin Neoplasms; Structure-Activity Relationship; Tetradecanoylphorbol Acetate | 1982 |
Must initiators come first? Tumorigenic and carcinogenic effects on skin of 3-methylcholanthrene and TPA in various sequences.
Topics: Animals; Carcinoma; Cell Division; DNA; Drug Synergism; Hyperplasia; Methylcholanthrene; Mice; Mice, Hairless; Papilloma; Phorbols; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1982 |
Inhibition of mouse skin tumor promotion by several inhibitors of arachidonic acid metabolism.
Topics: 5,8,11,14-Eicosatetraynoic Acid; Acetophenones; Animals; Arachidonic Acids; Biotransformation; Female; Male; Mice; Neoplasms, Experimental; Oxygenases; Papilloma; Phorbols; Phospholipases; Phospholipases A; Phospholipases A2; Prostaglandin Antagonists; Pyrazoles; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1982 |
Biological effects of phorbol ester tumor promoters in mouse skin.
Topics: Animals; Cell Division; Hyperplasia; Kinetics; Mice; Neoplasms, Experimental; Phorbols; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1982 |
Plasminogen activator induction and platelet aggregation by phorbol and some of its derivatives: correlation with skin irritancy and tumor-promoting activity.
Topics: Animals; Chick Embryo; Humans; Irritants; Mice; Phorbols; Plasminogen Activators; Platelet Aggregation; Skin; Skin Neoplasms; Structure-Activity Relationship | 1980 |
Effect of butyric acid on tumor promotion: a correction.
Topics: Animals; Butyrates; Mice; Phorbols; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1981 |
Characterization of arginase activity from mouse epidermis and its relation to ornithine decarboxylase induction by the tumor-promoting agent, 12-O-tetradecanoylphorbol-13-acetate.
Topics: Animals; Arginase; Carboxy-Lyases; Enzyme Induction; Female; Mice; Neoplasms, Experimental; Ornithine Decarboxylase; Phorbols; Polyamines; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1981 |
The time needed for normalization of hairless mouse epidermis after treatment with twice weekly topical skin applications of 10 nmol 12-O-tetradecanoylphorbol-13-acetate in acetone, or acetone alone, for 18 weeks. A morphologic and cell kinetic study.
Topics: Acetone; Animals; Cell Cycle; Female; Hyperplasia; Kinetics; Male; Mice; Mice, Inbred Strains; Phorbols; Skin; Skin Neoplasms; Skin Physiological Phenomena; Tetradecanoylphorbol Acetate; Time Factors | 1981 |
Structure-activity relationships in chick embryo fibroblasts for phorbol-related diterpene esters showing anomalous activities in vivo.
Topics: Animals; Cells, Cultured; Chick Embryo; Deoxy Sugars; Deoxyglucose; Fibroblasts; Fibronectins; Inflammation; Mice; Neoplasms, Experimental; Phorbol Esters; Phorbols; Skin Neoplasms; Structure-Activity Relationship; Tetradecanoylphorbol Acetate | 1980 |
Prostaglandin enhancement of skin tumor initiation and promotion.
Topics: Animals; Indomethacin; Mice; Neoplasms, Experimental; Phorbols; Prostaglandins; Prostaglandins E; Prostaglandins F; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1980 |
Inhibition of skin tumor promotion by retinoic acid and its metabolite 5,6-epoxyretinoic acid.
Topics: Animals; Female; Juvenile Hormones; Mice; Ornithine Decarboxylase Inhibitors; Papilloma; Phorbol Esters; Phorbols; Skin Neoplasms; Time Factors; Tretinoin | 1980 |
An organ culture of adult mouse skin: an in vitro model for studying the molecular mechanism of skin tumor promotion.
Topics: Animals; Carboxy-Lyases; DNA; Enzyme Induction; Female; Indomethacin; Mice; Models, Biological; Neoplasms, Experimental; Organ Culture Techniques; Ornithine Decarboxylase; Phorbols; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate; Tretinoin | 1980 |
Indomethacin enhancement of TPA tumor promotion in mice.
Topics: Animals; Drug Synergism; Female; Flurbiprofen; Indomethacin; Mice; Neoplasms, Experimental; Papilloma; Phorbols; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1980 |
Long-term effect of a tumor promoter, 12-O-tetradecanoylphorbol-13-acetate, on induced differentiation of Friend leukemia cells.
Topics: Acetamides; Animals; Cell Differentiation; Cells, Cultured; Cocarcinogenesis; Diamines; Friend murine leukemia virus; Leukemia, Experimental; Mice; Phorbols; Skin Neoplasms; Tetradecanoylphorbol Acetate; Time Factors; Virus Diseases | 1980 |
Inhibition by putrescine of the induction of epidermal ornithine decarboxylase activity and tumor promotion caused by 12-O-tetradecanoylphorbol-13-acetate.
Topics: Adenosylmethionine Decarboxylase; Animals; Carboxy-Lyases; Cocarcinogenesis; Enzyme Induction; Epidermis; Mice; Ornithine Decarboxylase; Phorbols; Putrescine; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1980 |
The carcinogenic effect of TPA (12-0-tetradecanoylphorbol-13-acetate) when applied to the skin of hairless mice.
Topics: Animals; Carcinoma, Squamous Cell; Fibrosarcoma; Mice; Mice, Nude; Papilloma; Phorbols; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate; Time Factors | 1979 |
Effects of structural changes on the tumor-promoting activity of phorbol myristate acetate on mouse skin.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Aldehydes; Animals; Carcinoma, Squamous Cell; Decanoates; Drug Synergism; Mice; Mice, Inbred ICR; Neoplasms, Experimental; Papilloma; Phorbols; Skin Neoplasms; Structure-Activity Relationship; Tetradecanoylphorbol Acetate | 1979 |
Inhibition of phorbol ester-induced tumor promotion in mice by vitamin A analog and anti-inflammatory steroid.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Cocarcinogenesis; Drug Synergism; Female; Fluocinolone Acetonide; Mice; Neoplasms, Experimental; Papilloma; Phorbols; Skin Neoplasms; Tetradecanoylphorbol Acetate; Vitamin A | 1979 |
Phorbol as a possible systemic promoting agent for skin carcinogenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Drug Synergism; Female; Injections, Intraperitoneal; Mice; Mice, Inbred ICR; Neoplasms, Experimental; Papilloma; Phorbols; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1976 |
On the biochemical mechanism of tumorigenesis in mouse skin. VII. The effects of tumor promoters on 3H-choline and 3H-glycerol incorporation into mouse epidermal phosphatidylcholine in relation to their effects on 3H-thymidine incorporation into DNA.
Topics: Animals; Choline; DNA, Neoplasm; Female; Glycerol; Mice; Neoplasms, Experimental; Phorbol Esters; Phorbols; Phosphatidylcholines; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate; Time Factors | 1976 |
Increased cyclic adenosine 3':5'-monophosphate phosphodiesterase activity in the epidermis of phorbol ester-treated mouse skin and in papillomas.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Animals; Colchicine; Enzyme Induction; Female; Mice; Neoplasms, Experimental; Papilloma; Phorbol Esters; Phorbols; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate; Vinblastine | 1979 |
Lymphocyte activation by the tumor-promoting agent 12-O-tetradecanoylphorbol-13-acetate (TPA).
Topics: Animals; Callitrichinae; Dimethyl Sulfoxide; Dogs; Guinea Pigs; Haplorhini; Herpesvirus 4, Human; Humans; Lymphocyte Activation; Macaca mulatta; Mice; Mice, Inbred BALB C; Mice, Inbred C3H; Mice, Inbred CBA; Mitogens; Pan troglodytes; Papio; Phorbols; Rats; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1979 |
Ornithine decarboxylase activity, cell proliferation, and tumor promotion in mouse epidermis in vivo.
Topics: Animals; Carboxy-Lyases; Cell Division; Cyclic AMP; Female; Growth Inhibitors; Hyperplasia; Mice; Neoplasms, Experimental; Ornithine Decarboxylase; Phorbol Esters; Phorbols; Physical Stimulation; Skin; Skin Neoplasms | 1979 |
Effects of 12-O-tetradecanoylphorbol-13-acetate and mezerein on epidermal ornithine decarboxylase activity, isoproterenol-stimulated levels of cyclic adenosine 3':5'-monophosphate, and induction of mouse skin tumors in vivo.
Topics: Animals; Antineoplastic Agents, Phytogenic; Cell Division; Cyclic AMP; Dermatitis, Contact; Diterpenes; Female; Isoproterenol; Mice; Neoplasms, Experimental; Ornithine Decarboxylase; Papilloma; Phorbol Esters; Phorbols; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1979 |
Binding of epidermal growth factor to primary and permanent cultures of mouse epidermal cells: inhibition by tumor-promoting phorbol esters.
Topics: Animals; Binding Sites; Cells, Cultured; Epidermal Growth Factor; Mice; Neoplasms, Experimental; Peptides; Phorbol Esters; Phorbols; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1979 |
Induction of the formation of new hair follicles in mouse tail epidermis by the tumor promoter 12-O-tetradecanoylphorbol-13-acetate.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Female; Hair; Mice; Neoplasms, Experimental; Papilloma; Phorbols; Skin; Skin Neoplasms; Tail; Tetradecanoylphorbol Acetate | 1977 |
Epidermal prostaglandins after topical application of a tumor promotor.
Topics: Administration, Topical; Animals; Male; Mice; Neoplasms, Experimental; Phorbols; Prostaglandins E; Prostaglandins F; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate; Time Factors | 1979 |
Inhibition of 12-O-tetradecanoylphorbol-13-acetate-induced ornithine decarboxylase activity in mouse epidermis by vitamin A analogs (retinoids).
Topics: Animals; Carboxy-Lyases; Drug Evaluation, Preclinical; Female; Mice; Neoplasms, Experimental; Ornithine Decarboxylase; Phorbols; Polyamines; Skin; Skin Neoplasms; Structure-Activity Relationship; Tetradecanoylphorbol Acetate; Vitamin A | 1978 |
Effect of aging in two-stage carcinogenesis on mouse skin with phorbol myristate acetate as promoting agent.
Topics: Aging; Animals; Female; Mice; Mice, Inbred ICR; Neoplasms, Experimental; Phorbols; Skin Neoplasms; Statistics as Topic; Tetradecanoylphorbol Acetate | 1978 |
Tumor-promoting activity of 2,3-dihydrophorbol myristate acetate and phorbolol myristate acetate in mouse skin.
Topics: Animals; Dermatitis, Contact; Female; Mice; Mice, Inbred ICR; Neoplasms, Experimental; Papilloma; Phorbols; Skin Neoplasms; Structure-Activity Relationship; Tetradecanoylphorbol Acetate | 1978 |
Non-phorbol mouse skin tumor promoters do not mimic phorbol myristate acetate in its effects on chick embryo fibroblasts.
Topics: Acetates; Animals; Anthralin; Cantharidin; Carcinogens; Cell Membrane; Chick Embryo; Cytochalasin B; Deoxyglucose; Fibroblasts; Glycoproteins; Lauric Acids; Neoplasms, Experimental; Oleic Acids; Palmitic Acids; Phenols; Phorbols; Skin Neoplasms; Stearic Acids; Tetradecanoylphorbol Acetate | 1978 |
Correlation of the inhibition by retinoids of tumor promoter-induced mouse epidermal ornithine decarboxylase activity and of skin tumor promotion.
Topics: Animals; Carboxy-Lyases; Enzyme Induction; Female; Mice; Neoplasms, Experimental; Ornithine Decarboxylase; Papilloma; Phorbols; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate; Time Factors; Tretinoin; Vitamin A | 1979 |
Inhibition of two-stage carcinogenesis in mouse skin with bis(2-chloroethyl)sulfide.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Benz(a)Anthracenes; Carcinoma, Squamous Cell; Female; Mice; Mice, Inbred ICR; Mustard Compounds; Neoplasms, Experimental; Papilloma; Phorbols; Skin Neoplasms; Sulfides; Tetradecanoylphorbol Acetate | 1976 |
The biochemistry of preneoplasia in mouse skin.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinogens; DNA, Neoplasm; Dose-Response Relationship, Drug; Female; Genes; Hyperplasia; Mice; Neoplasm Proteins; Papilloma; Phorbols; Precancerous Conditions; RNA, Neoplasm; Skin Neoplasms | 1976 |
Epidermal cell proliferation and promoting ability of phorbol esters.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Cell Division; Dose-Response Relationship, Drug; Drug Synergism; Edema; Female; Hyperplasia; Inflammation; Mice; Neoplasms, Experimental; Papilloma; Phorbol Esters; Phorbols; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1976 |
Diaplacental carcinogenesis: initiation with the carcinogens dimethylbenzanthracene (DMBA) and urethane during fetal life and postnatal promotion with the phorbol ester TPA in a modified 2-stage Berenblum/Mottram experiment.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Benz(a)Anthracenes; Drug Synergism; Female; Fetus; Gestational Age; Maternal-Fetal Exchange; Mice; Neoplasms, Experimental; Phorbols; Pregnancy; Skin Neoplasms; Tetradecanoylphorbol Acetate; Urethane | 1976 |
Improved tumour yields by means of a TPA-DMBA-TPA variation of the Berenrlum-Mottram experiment on the back skin of NMRI mice. The effect of stationary hyperplasia without inflammation.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Benz(a)Anthracenes; Carcinoma; Female; Hyperplasia; Mice; Mice, Inbred Strains; Neoplasms, Experimental; Papilloma; Phorbols; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate; Time Factors | 1976 |
Histone phosphorylation and synthesis of DNA and RNA during phases of proliferation and differentiation induced in mouse epidermis by the tumor promoter 12-O-tetradecanoyl-phorbol-13-acetate.
Topics: Animals; Cell Differentiation; Cell Division; DNA; DNA, Neoplasm; Female; Histones; Mice; Neoplasms, Experimental; Phorbols; Phosphorus; RNA; RNA, Neoplasm; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate; Time Factors | 1977 |
Effects of antiinflammatory agents on mouse skin tumor promotion, epidermal DNA synthesis, phorbol ester-induced cellular proliferation, and production of plasminogen activator.
Topics: Animals; Anti-Inflammatory Agents; Cell Division; Cells, Cultured; Depression, Chemical; DNA; Female; Fluocinolone Acetonide; Fluocinonide; Mice; Neoplasms, Experimental; Phorbol Esters; Phorbols; Plasminogen Activators; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1977 |
Vitamin A acid (retinoic acid), a potent inhibitor of 12-O-tetradecanoyl-phorbol-13-acetate-induced ornithine decarboxylase activity in mouse epidermis.
Topics: Adenosylmethionine Decarboxylase; Animals; Carboxy-Lyases; Drug Administration Schedule; Enzyme Induction; Female; In Vitro Techniques; Mice; Neoplasms, Experimental; Ornithine Decarboxylase; Ornithine Decarboxylase Inhibitors; Papilloma; Phorbols; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate; Tretinoin; Vitamin A | 1977 |
Phorbol esters stimulate DNA synthesis and ornithine decarboxylase activity in mouse epidermal cell cultures.
Topics: Animals; Carboxy-Lyases; Carcinogens; Cells, Cultured; DNA; Enzyme Induction; Mice; Ornithine Decarboxylase; Phorbol Esters; Phorbols; Skin; Skin Neoplasms; Structure-Activity Relationship | 1976 |
Selective promoting activity of phorbol myristate acetate in experimental skin carcinogenesis.
Topics: Animals; Carcinoma, Squamous Cell; Female; Fibrosarcoma; Male; Methylcholanthrene; Mice; Neoplasms, Experimental; Phorbols; Precancerous Conditions; Rhabdomyosarcoma; Skin Neoplasms; Tetradecanoylphorbol Acetate; Time Factors | 1976 |
Decrease of epidermal histidase activity by tumor-promoting phorbol esters.
Topics: Ammonia-Lyases; Animals; Benz(a)Anthracenes; Carcinogens; Depression, Chemical; Histidine Ammonia-Lyase; Male; Mice; Mice, Nude; Neoplasms, Experimental; Phorbols; Polysorbates; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate; Urethane | 1975 |
Keratin gene expression in mouse skin tumors and in mouse skin treated with 12-O-tetradecanoylphorbol-13-acetate.
Topics: Animals; Carcinoma; Female; Fluocinolone Acetonide; Gene Expression Regulation; Keratins; Mice; Molecular Weight; Papilloma; Phorbols; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate; Transcription, Genetic | 1985 |
Development of phorbol ester responsiveness in neonatal mouse epidermis: correlation between hyperplastic response and sensitivity to first-stage tumor promotion.
Topics: Animals; DNA; Female; Hyperplasia; Keratins; Mice; Mice, Inbred Strains; Mitosis; Ornithine Decarboxylase; Phorbols; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1985 |
TPA (12-O-tetradecanoyl-phorbol-13-acetate) as a carcinogen for mouse skin. A positive dose-response relationship.
Topics: Animals; Carcinogens; Dose-Response Relationship, Drug; Mice; Mice, Inbred Strains; Phorbols; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1985 |
The influence of different fixatives and a tumor promoter, 12-0-tetradecanoyl-phorbol-13-acetate (TPA), on the induction of so-called dark cells in mouse epidermis. A light microscopical study.
Topics: Acetone; Animals; Carcinogens; Cocarcinogenesis; Fixatives; Mice; Phorbols; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1986 |
[The actions of TPA-type as well as non-TPA type tumor promoters and their mechanism(s) in tumor promotion].
Topics: Acrylamides; Animals; Arachidonic Acid; Arachidonic Acids; Carcinogens; Cnidarian Venoms; Enzyme Activation; Humans; Lyngbya Toxins; Mice; Neoplasms, Experimental; Phorbols; Plant Extracts; Protein Kinase C; Receptors, Cell Surface; Skin Neoplasms; Structure-Activity Relationship; Tetradecanoylphorbol Acetate; Thapsigargin | 1986 |
Antipromotional activity of dietary N-(4-hydroxyphenyl)retinamide in two-stage skin tumorigenesis in CD-1 and SENCAR mice.
Topics: Animals; Carcinogens; Cocarcinogenesis; Diet; Drug Antagonism; Female; Fenretinide; Mice; Mice, Inbred Strains; Neoplasms, Multiple Primary; Phorbols; Skin Neoplasms; Species Specificity; Tetradecanoylphorbol Acetate; Tretinoin | 1986 |
Role of reactive oxygen in tumor promotion: implication of superoxide anion in promotion of neoplastic transformation in JB-6 cells by TPA.
Topics: Animals; Antioxidants; Arachidonic Acid; Arachidonic Acids; Cell Line; Cell Transformation, Neoplastic; Cocarcinogenesis; Hydroxides; Hydroxyl Radical; Lipoxygenase Inhibitors; Mannitol; Mice; Phorbols; Skin Neoplasms; Superoxide Dismutase; Superoxides; Tetradecanoylphorbol Acetate | 1985 |
Suppression of tumor promoter-induced chemiluminescence in mouse epidermal cells by several inhibitors of arachidonic acid metabolism.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Free Radicals; Lipoxygenase Inhibitors; Luminescent Measurements; Mice; Neutrophils; Phorbols; Skin; Skin Neoplasms; Superoxides; Tetradecanoylphorbol Acetate | 1985 |
Glycyrrhetic acid inhibits tumor-promoting activity of teleocidin and 12-O-tetradecanoylphorbol-13-acetate in two-stage mouse skin carcinogenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; ErbB Receptors; Female; Glycyrrhetinic Acid; HeLa Cells; Lyngbya Toxins; Mice; Mice, Inbred ICR; Phorbols; Phospholipids; Phosphorus Radioisotopes; Quercetin; Receptors, Cell Surface; Skin Neoplasms; Sulfonamides; Tetradecanoylphorbol Acetate; Time Factors | 1986 |
Inhibitory effect of toluene on tumor promotion in mouse skin.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Benzo(a)pyrene; Carcinogens; Cocarcinogenesis; Drug Antagonism; Male; Mice; Mice, Inbred C3H; Phorbols; Skin Neoplasms; Solvents; Tetradecanoylphorbol Acetate; Toluene | 1986 |
Inhibition of 12-O-tetradecanoylphorbol-13-acetate-induced tumor promotion and epidermal ornithine decarboxylase activity in mouse skin by palmitoylcarnitine.
Topics: Animals; Calcium; Carnitine; Dose-Response Relationship, Drug; Egtazic Acid; Female; Mice; Mice, Inbred Strains; Ornithine Decarboxylase; Ornithine Decarboxylase Inhibitors; Palmitoylcarnitine; Phorbols; Protein Kinase C; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate; Time Factors | 1986 |
Inhibition of 12-O-tetradecanoylphorbol-13-acetate-induced epidermal ornithine decarboxylase activity and tumor promotion by N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide (W-7) in mouse skin.
Topics: Animals; Calcium; Calmodulin; Enzyme Induction; Female; Lyngbya Toxins; Mice; Mice, Inbred Strains; Ornithine Decarboxylase; Papilloma; Phorbols; Protein Kinase C; Skin; Skin Neoplasms; Sulfonamides; Tetradecanoylphorbol Acetate | 1986 |
[Factors controlling tumor promotion induced by TPA].
Topics: Animals; Benzoquinones; Enzyme Activation; Lipoxygenase Inhibitors; Mice; Ornithine Decarboxylase; Palmitoylcarnitine; Papilloma; Phorbols; Phospholipases; Phospholipases A; Phospholipases A2; Protein Kinase C; Quinones; Skin Neoplasms; Stimulation, Chemical; Tetradecanoylphorbol Acetate | 1986 |
Three-stage tumorigenesis in mouse skin: DNA synthesis as a prerequisite for the conversion stage induced by TPA prior to initiation.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Cocarcinogenesis; DNA; Female; Hydroxyurea; Mice; Mice, Inbred Strains; Phorbol Esters; Phorbols; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1986 |
Hyperthermia and phorbol ester tumor promotion in mouse skin.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinoma; Cocarcinogenesis; Female; Hyperthermia, Induced; Mice; Papilloma; Phorbols; Skin; Skin Neoplasms; Skin Temperature; Tetradecanoylphorbol Acetate | 1986 |
Ionizing radiation as an initiator in the mouse two-stage model of skin tumor formation.
Topics: Animals; Carcinogens; Carcinoma, Squamous Cell; Cocarcinogenesis; Female; Mice; Neoplasms, Experimental; Papilloma; Phorbols; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate; Time Factors; X-Rays | 1986 |
Enhancement of two-stage skin carcinogenesis by exposure of distant skin to UV radiation.
Topics: Animals; Carcinoma, Squamous Cell; Cocarcinogenesis; Female; Fibrosarcoma; Immune Tolerance; Mice; Mice, Inbred C3H; Neoplasms, Radiation-Induced; Papilloma; Phorbols; Skin Neoplasms; Tetradecanoylphorbol Acetate; Time Factors; Ultraviolet Rays | 1985 |
Effects of short-term exposure to the tumor promoter, 12-O-tetradecanoylphorbol-13-acetate on skin carcinogenesis in SENCAR mice.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinoma; Cocarcinogenesis; Female; Mice; Papilloma; Phorbols; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1985 |
12-O-tetradecanoylphorbol-13-acetate-induced rapid loss of persistent 7,12-dimethylbenz[a]anthracene-DNA adducts in mouse epidermis and dermis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Cocarcinogenesis; DNA; Epidermis; Female; Mice; Mice, Inbred BALB C; Phorbols; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1985 |
12-O-tetradecanoylphorbol-13-acetate promotes tumors prior to initiation in two-stage promotion.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinogens; Cocarcinogenesis; Diterpenes; Enzyme Induction; Female; Mice; Models, Biological; Ornithine Decarboxylase; Ornithine Decarboxylase Inhibitors; Papilloma; Phorbols; Skin Neoplasms; Terpenes; Tetradecanoylphorbol Acetate; Time Factors | 1985 |
The skin tumor-promoter 12-O-tetradecanoylphorbol-13-acetate induces transcription of the c-fos proto-oncogene in human bladder epithelial cells.
Topics: Cells, Cultured; Epithelium; Humans; Phorbols; Proto-Oncogene Mas; Proto-Oncogenes; Skin Neoplasms; Tetradecanoylphorbol Acetate; Transcription, Genetic; Urinary Bladder | 1986 |
Cutaneous changes during prolonged application of 12-O-tetradecanoylphorbol-13-acetate on mouse skin and residual effects after cessation of treatment.
Topics: Animals; Epidermis; Female; Hyperplasia; Mast Cells; Mice; Phorbols; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1985 |
Dermal collagen metabolism during tumor promotion with 12-O-tetradecanoylphorbol-13-acetate in mouse skin.
Topics: Animals; Collagen; Female; Hydroxyproline; Methylcholanthrene; Mice; Papilloma; Phorbols; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1985 |
Retinoyl-phorbol-acetate is a complete skin tumor promoter in SENCAR mice.
Topics: Animals; Female; Mice; Mice, Inbred Strains; Phorbol Esters; Phorbols; Skin Neoplasms; Species Specificity | 1985 |
Dose and schedule of oral retinoic acid and indomethacin needed to effectively inhibit phorbol ester-induced epidermal ornithine decarboxylase activity.
Topics: Administration, Oral; Animals; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Indomethacin; Male; Mice; Mice, Inbred Strains; Ornithine Decarboxylase Inhibitors; Phorbols; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate; Tretinoin | 1985 |
Enhancement by adriamycin of the effects of 12-O-tetradecanoylphorbol-13-acetate on mouse epidermal glutathione peroxidase activity, ornithine decarboxylase induction and skin tumor promotion.
Topics: Administration, Topical; Animals; Dose-Response Relationship, Drug; Doxorubicin; Drug Interactions; Enzyme Induction; Epidermis; Female; Glutathione; Glutathione Disulfide; Glutathione Peroxidase; Mice; Ornithine Decarboxylase; Phorbols; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate; Time Factors | 1985 |