phorbol has been researched along with Starvation* in 1 studies
1 other study(ies) available for phorbol and Starvation
| Article | Year |
|---|---|
Acute effects of tumor-promoting phorbol esters on hepatic intermediary metabolism.
In hepatocytes isolated from meal-fed rats, phorbol 12-myristate 13-acetate as well as phorbol 12,13-didecanoate stimulated de novo fatty acid synthesis in a dose-dependent manner. Moreover, phorbol 12-myristate 13-acetate inhibited ketogenesis from exogenous oleate, but slightly enhanced oleate esterification. The stimulation of esterification was more pronounced with endogenously synthesized fatty acids. In hepatocytes from 24h-starved rats a moderate stimulation of gluconeogenesis and ureogenesis was observed with glutamine as substrate. It is concluded that tumor-promoting phorbol esters mimic the short-term effects of insulin on hepatic fatty acid metabolism. Topics: Animals; Fatty Acids; Food; Gluconeogenesis; Glutamine; Ketone Bodies; Liver; Male; Phorbol Esters; Phorbols; Rats; Rats, Inbred Strains; Starvation; Tetradecanoylphorbol Acetate | 1985 |