phorbol and HIV-Infections

phorbol has been researched along with HIV-Infections* in 2 studies

Other Studies

2 other study(ies) available for phorbol and HIV-Infections

Article	Year
Identification of proximal biomarkers of PKC agonism and evaluation of their role in HIV reactivation. Antiviral research, 2017, Volume: 139 The HIV latent CD4. Human CD4. Treatment of primary human CD4. Overall, our results offer new insights into the mechanism of action of PKC agonists, biomarkers of pathway engagement, and the potential role of EGR family in HIV reactivation. Topics: Biomarkers; CD4-Positive T-Lymphocytes; Cells, Cultured; Diterpenes; Drug Agonism; Early Growth Response Protein 1; Early Growth Response Protein 3; Gene Expression; HIV Infections; HIV-1; Humans; Jurkat Cells; Male; Phorbols; Protein Kinase C; Sequence Analysis, RNA; Virus Activation; Virus Latency	2017
Antiviral Activity of Diterpene Esters on Chikungunya Virus and HIV Replication. Journal of natural products, 2015, Jun-26, Volume: 78, Issue:6 Recently, new daphnane, tigliane, and jatrophane diterpenoids have been isolated from various Euphorbiaceae species, of which some have been shown to be potent inhibitors of chikungunya virus (CHIKV) replication. To further explore this type of compound, the antiviral activity of a series of 29 commercially available natural diterpenoids was evaluated. Phorbol-12,13-didecanoate (11) proved to be the most potent inhibitor, with an EC50 value of 6.0 ± 0.9 nM and a selectivity index (SI) of 686, which is in line with the previously reported anti-CHIKV potency for the structurally related 12-O-tetradecanoylphorbol-13-acetate (13). Most of the other compounds exhibited low to moderate activity, including an ingenane-type diterpene ester, compound 28, with an EC50 value of 1.2 ± 0.1 μM and SI = 6.4. Diterpene compounds are known also to inhibit HIV replication, so the antiviral activities of compounds 1-29 were evaluated also against HIV-1 and HIV-2. Tigliane- (4β-hydroxyphorbol analogues 10, 11, 13, 15, 16, and 18) and ingenane-type (27 and 28) diterpene esters were shown to inhibit HIV replication in vitro at the nanomolar level. A Pearson analysis performed with the anti-CHIKV and anti-HIV data sets demonstrated a linear relationship, which supported the hypothesis made that PKC may be an important target in CHIKV replication. Topics: Anti-HIV Agents; Antiviral Agents; Chikungunya virus; Diterpenes; DNA Replication; Esters; Euphorbiaceae; HIV Infections; HIV-1; HIV-2; Molecular Structure; Phorbol Esters; Tetradecanoylphorbol Acetate; Virus Replication	2015

Article

Year

Identification of proximal biomarkers of PKC agonism and evaluation of their role in HIV reactivation.

Antiviral research, 2017, Volume: 139

The HIV latent CD4. Human CD4. Treatment of primary human CD4. Overall, our results offer new insights into the mechanism of action of PKC agonists, biomarkers of pathway engagement, and the potential role of EGR family in HIV reactivation.

Topics: Biomarkers; CD4-Positive T-Lymphocytes; Cells, Cultured; Diterpenes; Drug Agonism; Early Growth Response Protein 1; Early Growth Response Protein 3; Gene Expression; HIV Infections; HIV-1; Humans; Jurkat Cells; Male; Phorbols; Protein Kinase C; Sequence Analysis, RNA; Virus Activation; Virus Latency

2017

Antiviral Activity of Diterpene Esters on Chikungunya Virus and HIV Replication.

Journal of natural products, 2015, Jun-26, Volume: 78, Issue:6

Recently, new daphnane, tigliane, and jatrophane diterpenoids have been isolated from various Euphorbiaceae species, of which some have been shown to be potent inhibitors of chikungunya virus (CHIKV) replication. To further explore this type of compound, the antiviral activity of a series of 29 commercially available natural diterpenoids was evaluated. Phorbol-12,13-didecanoate (11) proved to be the most potent inhibitor, with an EC50 value of 6.0 ± 0.9 nM and a selectivity index (SI) of 686, which is in line with the previously reported anti-CHIKV potency for the structurally related 12-O-tetradecanoylphorbol-13-acetate (13). Most of the other compounds exhibited low to moderate activity, including an ingenane-type diterpene ester, compound 28, with an EC50 value of 1.2 ± 0.1 μM and SI = 6.4. Diterpene compounds are known also to inhibit HIV replication, so the antiviral activities of compounds 1-29 were evaluated also against HIV-1 and HIV-2. Tigliane- (4β-hydroxyphorbol analogues 10, 11, 13, 15, 16, and 18) and ingenane-type (27 and 28) diterpene esters were shown to inhibit HIV replication in vitro at the nanomolar level. A Pearson analysis performed with the anti-CHIKV and anti-HIV data sets demonstrated a linear relationship, which supported the hypothesis made that PKC may be an important target in CHIKV replication.

Topics: Anti-HIV Agents; Antiviral Agents; Chikungunya virus; Diterpenes; DNA Replication; Esters; Euphorbiaceae; HIV Infections; HIV-1; HIV-2; Molecular Structure; Phorbol Esters; Tetradecanoylphorbol Acetate; Virus Replication

2015